Canal de Potássio
Os canais de potássio são um grupo diversificado de proteínas de membrana que facilitam o fluxo de íons de potássio (K+) através da membrana celular. Esses canais desempenham um papel crucial na manutenção do potencial de membrana em repouso, na regulação do volume celular e no controle da excitabilidade de neurônios e células musculares. Os canais de potássio estão envolvidos em vários processos fisiológicos, incluindo a regulação do ritmo cardíaco, a secreção de insulina e a liberação de neurotransmissores. A desregulação dos canais de potássio está associada a condições como arritmias, epilepsia e hipertensão. Na CymitQuimica, oferecemos uma ampla gama de moduladores de canais de potássio para apoiar sua pesquisa em eletrofisiologia, saúde cardiovascular e neurobiologia.
Foram encontrados 280 produtos de "Canal de Potássio"
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BeKm-1
CAS:Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.Fórmula:C174H261N51O52S6Pureza:98%Cor e Forma:SolidPeso molecular:4091.65ShK-Dap22
CAS:Potent KV1.3 channel blocker; Kd 23 pM; selective; inhibits T cell activation; IC50 < 500 pM for mKV1.3.Fórmula:C166H268N54O48S7Pureza:98%Cor e Forma:SolidPeso molecular:4012.7Guangxitoxin 1E
CAS:Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.Fórmula:C178H248N44O45S7Pureza:98%Cor e Forma:SolidPeso molecular:3948.61Phe-Met-Arg-Phe, amide
CAS:Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.Fórmula:C29H42N8O4SPureza:98%Cor e Forma:SolidPeso molecular:598.76Pinacidil monohydrate
CAS:Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.Fórmula:C13H21N5OPureza:99.94% - 99.98%Cor e Forma:PowderPeso molecular:263.34MASP-2-IN-1
MASP-2-IN-1 (Compound 77) is an inhibitor of mannan-binding lectin-associated serine proteases (MASP), specifically targeting MASP2 and MASP3, with IC50 values of 11.4 nM and 13.2 µM, respectively. It shows weak inhibitory activity on hERG with an IC50 of 175 µM. This compound exhibits poor stability in mouse plasma, with a half-life of 4.4 hours.Fórmula:C22H21N7O3SCor e Forma:SolidPeso molecular:463.512Lei-Dab7
CAS:Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.Fórmula:C141H236N46O39S6Pureza:98%Cor e Forma:SolidPeso molecular:3392.06GsAF-II
GsAF-II is a peptide toxin that selectively blocks hERG1 subtype potassium channels through a voltage-dependent mechanism and impedes Nav1.x subtype sodiumFórmula:C176H261N47O45S7Pureza:98%Cor e Forma:SolidPeso molecular:3979.7Heteropodatoxin-1
<p>Heteropodatoxin-1 (HpTx1), a spider peptide toxin, acts as an inhibitor of the Kv4.2 current, while concurrently inhibiting Nav1.7 and activating Nav1.9</p>Fórmula:C168H238N46O51S6Pureza:98%Cor e Forma:SolidPeso molecular:3910.35AmmTX3
KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.Fórmula:C158H262N50O48S6Pureza:98%Cor e Forma:SolidPeso molecular:3822.47Ebio3
Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.Fórmula:C19H23F2N3O2Cor e Forma:SolidPeso molecular:363.4Dendrotoxin K
CAS:Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.Fórmula:C294H462N84O75S6Cor e Forma:SolidPeso molecular:6559.66BKCa activator-1
BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.Fórmula:C22H23F7N2O3Cor e Forma:SolidPeso molecular:496.418Guanfu base A
CAS:Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.Fórmula:C24H31NO6Pureza:99.71% - 99.85%Cor e Forma:SolidPeso molecular:429.5HG1 Toxin
<p>HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, known for its ability to inhibit the potassium channel Kv1.3 (potassium channel Kv1.3). Additionally, HG1 Toxin exhibits trypsin inhibitory activity (Ki=107 nM), making it useful for research into autoimmune diseases.</p>Fórmula:C337H503N103O97S6Peso molecular:7736.59176Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C179H274N50O55S7Pureza:98%Cor e Forma:SolidPeso molecular:4230Agitoxin-2
CAS:Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).Fórmula:C169H278N54O48S8Pureza:98%Cor e Forma:SolidPeso molecular:4090.87Apamin
CAS:<p>Apamin: 18-amino acid bee venom peptide, blocks SK channels, anti-inflammatory, anti-fibrotic, strongly basic.</p>Fórmula:C79H131N31O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2027.34Charybdotoxin
CAS:Specific inhibitor of the big conductance Ca2+-activated K+ channel.Fórmula:C176H277N57O55S7Pureza:98%Cor e Forma:SolidPeso molecular:4295.95Margatoxin
CAS:KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.Fórmula:C178H286N52O50S7Pureza:98%Cor e Forma:SolidPeso molecular:4178.96
