Receptor CGRP
Os receptores de CGRP estão envolvidos na transmissão da dor e na regulação do fluxo sanguíneo. O CGRP é um neuropeptídeo que desempenha um papel crítico na fisiopatologia da enxaqueca, dilatando os vasos sanguíneos e modulando as vias de sinalização da dor. Alvejar os receptores de CGRP tornou-se uma abordagem promissora no desenvolvimento de terapias para enxaqueca. Na CymitQuimica, oferecemos uma variedade de moduladores de receptores de CGRP para apoiar sua pesquisa em manejo da dor, neurobiologia e saúde vascular.
Foram encontrados 55 produtos para "Receptor CGRP".
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Vazegepant hydrochloride
CAS:Vazegepant hydrochloride (Vazegepant HCl) is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.Fórmula:C36H47ClN8O3Pureza:98.93%Cor e Forma:White SolidPeso molecular:675.3Calcitonin(salmon) Acetate(47931-85-1(free base))
Calcitonin(salmon)Acetate(47931-85-1(free base))(Salmon calcitonin) , a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5Fórmula:C147H243N44O50S2Pureza:99.29% - 99.63%Cor e Forma:White SolidPeso molecular:3490.94HCGRP-(8-37) acetate
HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.Fórmula:C141H234N44O40Pureza:99.53%Cor e Forma:SolidPeso molecular:3185.64Atogepant
CAS:Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.Fórmula:C29H23F6N5O3Pureza:99.66%Cor e Forma:SolidPeso molecular:603.52Ref: TM-T26682
1mg147,00€5mg250,00€10mg313,00€1mL*10mM (DMSO)334,00€25mg620,00€50mg1.108,00€100mg1.611,00€200mg2.178,00€Eptinezumab
CAS:Eptinezumab is a humanised monoclonal antibody targeting CGRP (calcitonin gene-related peptide), which prevents CGRP binding to its receptor, migraine.Pureza:95% - 96.9% (SDS-PAGE); 99.8% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:143.27 kDaFremanezumab
CAS:Fremanezumab (TEV-48125) is a humanised monoclonal antibody targeting CGRP, capable of neutralising human, mouse and rat CGRP, migraine.Pureza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:145.49 kDaCGRP antagonist 1
CAS:CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for theFórmula:C29H26N4O4Pureza:99.55%Cor e Forma:SolidPeso molecular:494.54Ubrogepant
CAS:Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.Fórmula:C29H26F3N5O3Pureza:99.45% - 99.78%Cor e Forma:Yellow SolidPeso molecular:549.54Ref: TM-T17194
1mg144,00€5mg358,00€1mL*10mM (DMSO)432,00€10mg565,00€25mg880,00€50mg1.161,00€100mg1.594,00€Rimegepant sulfate hydrate
CAS:Rimegepant (BMS-927711/BHV-3000): oral CGRP blocker for migraines, effective without vasoconstriction, beats placebo, well-tolerated.Fórmula:C56H64F4N12O13SCor e Forma:SolidPeso molecular:1221.2526CGRP antagonist 7
CAS:CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki value of 0.029 nM. It effectively inhibits CGRP receptor-mediated cyclic adenosine monophosphate (cAMP) production, with an IC50 value of 1.5 nM. This compound is useful in migraine research.Fórmula:C30H32FN5O3Cor e Forma:SolidPeso molecular:529.61BI-44370
CAS:BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.Fórmula:C35H47N5O6Cor e Forma:SolidPeso molecular:633.78HTL22562
CAS:HTL22562 is a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine.Fórmula:C40H49N11O5Cor e Forma:SolidPeso molecular:763.904MK-3207 Hydrochloride
CAS:MK-3207 Hydrochloride (MK-3207 HCl) is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Phase 2.Fórmula:C31H30ClF2N5O3Pureza:98.19%Cor e Forma:Yellow SolidPeso molecular:594.05DNA crosslinker 6
CAS:DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.Fórmula:C19H21N7OCor e Forma:SolidPeso molecular:363.42
