P-gp
A P-glicoproteína é uma bomba de efluxo dependente de ATP que transporta uma ampla variedade de substratos, incluindo medicamentos, toxinas e lipídios, para fora das células. Ela desempenha um papel crítico na resistência a medicamentos, particularmente no câncer, ao reduzir a concentração intracelular de agentes quimioterápicos. A P-gp também está envolvida na barreira hematoencefálica, influenciando a exposição do sistema nervoso central a vários compostos. Na CymitQuimica, oferecemos uma variedade de moduladores de P-gp para apoiar sua pesquisa em resistência a medicamentos, farmacocinética e desenvolvimento terapêutico.
Foram encontrados 56 produtos para "P-gp".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Fórmula:C17H19NO3Pureza:98.41% - 98.51%Cor e Forma:SolidPeso molecular:285.34Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Cor e Forma:Cream Fine PowderPeso molecular:480.43Encequidar mesylate
CAS:Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
Fórmula:C39H40N6O10SPureza:99.84%Cor e Forma:SolidPeso molecular:784.83Atazanavir
CAS:Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.Fórmula:C38H52N6O7Pureza:98% - 99.95%Cor e Forma:Crystalline SolidPeso molecular:704.86Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Fórmula:C38H52N6O7·H2SO4Pureza:99.31% - 99.40%Cor e Forma:SolidPeso molecular:802.93Ref: TM-T0100
5mg44,00€1mL*10mM (DMSO)50,00€10mg58,00€25mg90,00€50mg114,00€100mg170,00€200mg250,00€500mg425,00€(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFórmula:C30H52O3Pureza:97.07% - 98.91%Cor e Forma:SolidPeso molecular:460.73Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Fórmula:C21H21F2N3OSPureza:99.58%Cor e Forma:SolidPeso molecular:401.47Ref: TM-T13383
1mg92,00€5mg193,00€1mL*10mM (DMSO)210,00€10mg293,00€25mg528,00€50mg795,00€100mg1.153,00€Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Fórmula:C26H37ClN2O4Pureza:99.47%Cor e Forma:SolidPeso molecular:477.04Ref: TM-T16339
1mg34,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg177,00€25mg299,00€50mg447,00€100mg602,00€200mg842,00€Dofequidar fumarate
CAS:Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through theFórmula:C34H35N3O7Pureza:99.93%Cor e Forma:SolidPeso molecular:597.66Ref: TM-T11071
1mg37,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)90,00€10mg118,00€25mg233,00€50mg447,00€100mg650,00€500mg1.369,00€Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Fórmula:C27H39ClN2O4Pureza:98.7% - 99.98%Cor e Forma:White To Off-White PowderPeso molecular:491.06Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Cor e Forma:SolidPeso molecular:494Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Fórmula:C23H27FN4O2Pureza:99.73%Cor e Forma:Crystalline SolidPeso molecular:410.48Ref: TM-T0351
10mg48,00€1mL*10mM (DMSO)50,00€25mg56,00€50mg88,00€100mg122,00€200mg192,00€500mg323,00€Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Fórmula:C63H111N11O12Pureza:95% - >99.99%Cor e Forma:SolidPeso molecular:1214.62Ref: TM-T17216
1mg411,00€5mg1.350,00€1mL*10mM (DMSO)1.900,00€10mg2.250,00€25mg4.950,00€100mg9.630,00€P-gp modulator-5
P-gp Modulator-5 (compound 25) serves as a modulator of P-gp, effectively inhibiting the proliferation of multidrug-resistant (MDR) tumors. This compound suppresses the function of drug efflux pumps in MDR cells, which results in significant accumulation of ROS and modifications in cell cycle profiles.Fórmula:C19H16N2O5Cor e Forma:SolidPeso molecular:352.34YS-370
CAS:YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.Fórmula:C37H35BrN4O3Pureza:98.05%Cor e Forma:SolidPeso molecular:663.6WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Fórmula:C16H13N5OS2Cor e Forma:SolidPeso molecular:355.44CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Fórmula:C111H131N23O30SCor e Forma:SolidPeso molecular:2299.43P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Fórmula:C30H28N2O6Pureza:99.85%Cor e Forma:SoildPeso molecular:512.55P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Fórmula:C37H38N2O8Cor e Forma:SolidPeso molecular:638.71Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Fórmula:C40H58N4O18S2Pureza:98.13%Cor e Forma:SolidPeso molecular:947.04
