Canal de Sódio
Os canais de sódio são proteínas de membrana essenciais que permitem a passagem de íons de sódio (Na+) através da membrana celular, gerando e propagando sinais elétricos em neurônios, células musculares e outros tecidos excitáveis. Esses canais são vitais para a iniciação e condução de potenciais de ação, sendo cruciais em processos como a transmissão de impulsos nervosos, contração muscular e função cardíaca. A desregulação dos canais de sódio pode levar a distúrbios neurológicos, arritmias e condições de dor crônica. Na CymitQuimica, oferecemos uma variedade de moduladores de canais de sódio para apoiar sua pesquisa em neurobiologia, cardiologia e manejo da dor.
Foram encontrados 209 produtos de "Canal de Sódio"
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Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Fórmula:C272H429N85O84S10Pureza:98%Cor e Forma:SolidPeso molecular:6554.51Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFórmula:C36H67N11O8S2Pureza:98%Cor e Forma:SolidPeso molecular:846.12CL-424032
CAS:CL-424032 is an inhibitor of sodium channels (sodium channel).Fórmula:C12H7F3N4O2Cor e Forma:SolidPeso molecular:296.21PF-06456384 trihydrochloride
CAS:PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.Fórmula:C35H35Cl3F3N7O3S2Pureza:99.16%Cor e Forma:SolidPeso molecular:829.18Mepivacaine hydrochloride
CAS:Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.Fórmula:C15H22N2O·HClPureza:98.76% - 99.94%Cor e Forma:White Or Off White Crystalline PowderPeso molecular:282.81Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Cor e Forma:Odour SolidHuwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Fórmula:C174H278N52O51S6Pureza:98%Cor e Forma:SolidPeso molecular:4106.79Zandatrigine
CAS:Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsyFórmula:C22H25FN4O2S2Pureza:99.98%Cor e Forma:SolidPeso molecular:460.59OD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Fórmula:C308H466N90O95S8Pureza:98%Cor e Forma:SolidPeso molecular:7206.1Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Fórmula:C176H269N51O48S6Pureza:98%Cor e Forma:SolidPeso molecular:4059.74Benzonatate (PEGn)
CAS:Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.Fórmula:(C2H4O)nC12H17NO2Cor e Forma:SolidAnthopleurin-A
CAS:Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].Fórmula:C220H326N64O67S6Peso molecular:5131.72Batrachotoxin
CAS:Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Fórmula:C31H42N2O6Peso molecular:538.67Sodium Channel Targeted Library
<p>A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;</p>Cor e Forma:Odour SolidLifarizine FA
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.Fórmula:C30H34N4O2Pureza:99.55%Cor e Forma:SolidPeso molecular:482.62GX 201
CAS:GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Fórmula:C25H27ClF4N2O4SPureza:99.81%Cor e Forma:SolidPeso molecular:563ProTx II
CAS:<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Fórmula:C168H250N46O41S8Pureza:98%Cor e Forma:SolidPeso molecular:3826.59Solpecainol
CAS:solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.Fórmula:C18H23NO3Pureza:99.71%Cor e Forma:SoildPeso molecular:301.38ETD001
CAS:ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.Fórmula:C41H57F6N9O16Cor e Forma:SolidPeso molecular:1045.93Nav1.7-IN-18
Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).Fórmula:C30H33Cl2F2NO4Cor e Forma:SolidPeso molecular:580.49
