Canais de Cálcio
Os canais de cálcio são proteínas de membrana que regulam o fluxo de íons de cálcio para dentro e fora das células, o que é essencial para várias funções celulares, incluindo a contração muscular, a liberação de neurotransmissores e a expressão gênica. A desregulação da atividade dos canais de cálcio está associada a condições como hipertensão, arritmias cardíacas e distúrbios neurológicos. Na CymitQuimica, oferecemos uma ampla seleção de moduladores de canais de cálcio para apoiar sua pesquisa em saúde cardiovascular, neurobiologia e transdução de sinais.
Foram encontrados 543 produtos de "Canais de Cálcio"
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MMK 1
CAS:Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), >10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.Fórmula:C75H123N19O18SPureza:98%Cor e Forma:SolidPeso molecular:1610.97sFTX-3.3
CAS:sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively.Fórmula:C12H29N7OCor e Forma:SolidPeso molecular:287.412Nesiritide acetate
CAS:Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.Fórmula:C143H244N50O42S4C2H4O2Cor e Forma:SolidPeso molecular:3524.1RyRs activator 5
Compound A-1 (RyRs activator 5) is an efficacious agonist of ryanodine receptors, exhibiting activity against Spodoptera frugiperda [1].Cor e Forma:Odour SolidO-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine
CAS:O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1Fórmula:C20H20ClNO7Cor e Forma:SolidPeso molecular:421.83(R)-IDHP
CAS:(R)-IDHP, a salvia derivative, relaxes blood vessels by blocking calcium channels, aiding cardiovascular research.Fórmula:C12H16O5Cor e Forma:SolidPeso molecular:240.25Cd1a
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) asCor e Forma:Odour SolidGlutarimide
CAS:Compound PDK0025, with CAS No. 1121-89-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0025 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C5H7NO2Peso molecular:113.11Ethacrynic acid D5
CAS:Ethacrynic acid: a diuretic, anti-inflammatory, inhibits calcium channels, GSTs, NF-kB pathway, and modulates leukotriene; has deuterium-labeled form.Fórmula:C13H12Cl2O4Pureza:98%Cor e Forma:SolidPeso molecular:308.17ω-Conotoxin MVIIC TFA
ω-Conotoxin MVIIC TFA is a peptide and neurotoxin blocks P-type and q-type voltage-sensitive neuronal Ca ++ channels (VGCCs) radiolabel immunoprecipitation.Fórmula:C106H178N40O32S7·C2HF3O2Cor e Forma:SolidPeso molecular:2863.271-(aminomethyl)cyclopropanecarboxylic acid hydrochloride
CAS:<p>1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride inhibits L amino acid transporter proteins and the α2δ subunit of voltage-gated calcium channels.1-(</p>Fórmula:C5H10ClNO2Pureza:>99.99%Cor e Forma:SolidPeso molecular:151.59Amlodipine aspartic acid impurity
CAS:Amlodipine aspartic acid: a calcium blocker with antihypertensive effects; contains specific impurities.Fórmula:C24H29ClN2O9Pureza:98%Cor e Forma:SolidPeso molecular:524.95D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
CAS:Ins(1,4,5,6)-P4, a signal-transducing inositol oligophosphate, increases 2-14x in cells post-Salmonella infection and modulates EGF signaling.Fórmula:C6H12Na4O18P4Cor e Forma:SolidPeso molecular:588Huwentoxin I
CAS:Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.Fórmula:C161H246N48O44S6Pureza:98%Cor e Forma:SolidPeso molecular:3750.36ω-Conotoxin GVIA
CAS:Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.Fórmula:C120H182N38O43S6Pureza:98%Cor e Forma:SolidPeso molecular:3037Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFórmula:C36H67N11O8S2Pureza:98%Cor e Forma:SolidPeso molecular:846.12Ser-Ala-alloresact acetate
<p>Ser-Ala-alloresact acetate is a sperm-activating peptide (SAP) that is released by marine invertebrate eggs and plays an important role in fertilization.</p>Fórmula:C44H75N13O16S2Pureza:99.73%Cor e Forma:SolidPeso molecular:1106.28Calcium Channel Compound Library
A unique collection of 140 calcium channel blockers and agonists for high throughput and high content screening;Cor e Forma:Odour SolidRef: TM-L7200
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultar2-Nitrobenzoic acid
CAS:2-Nitrobenzoic acid is an anti-growth agent with an IC50 of 8.3 μM against Jurkat cells with T-type Ca²⁺ channel alpha 1H/delta 25.Fórmula:C7H5NO4Pureza:99.97%Cor e Forma:SoildPeso molecular:167.12Triphenylethylene
CAS:Compound PDK0283, with CAS No. 58-72-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0283 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C20H16Cor e Forma:White PowderPeso molecular:256.34Ins(1,4,5)-P3 hexapotassium salt
CAS:<p>D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.</p>Fórmula:C6H9K6O15P3Pureza:98%Cor e Forma:SolidPeso molecular:648.641,4-Dihydropyridine
1,4-Dihydropyridine acts as an antagonist for calcium channels (calcium channel), specifically blocking the L-type calcium channels. This action reduces the influx of calcium ions into cardiac and vascular smooth muscle cells, consequently decreasing cardiac contractility and heart rate, dilating blood vessels, and lowering blood pressure.Fórmula:C12H17NO4Cor e Forma:SolidPeso molecular:239.27Elgodipine
CAS:Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.Fórmula:C29H33FN2O6Pureza:99.84% - 99.98%Cor e Forma:SolidPeso molecular:524.58Lyso-Globotriaosylceramide (d18:1)
CAS:Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.Fórmula:C36H67NO17Cor e Forma:SolidPeso molecular:785.922Flosatidil
CAS:Flosatidil is a small molecule voltage-gated calcium channel complex (VDCCs) blocker for the treatment of neurological disorders and cardiovascular diseases,Fórmula:C26H34F3N3O3SPureza:99.87% - 99.99%Cor e Forma:SolidPeso molecular:525.63ProTx-I
CAS:<p>Selective blocker for CaV3.1 (IC50 = 0.2 μM), CaV3.2 (31.8 μM), also inhibits NaV1.8 and blocks KV2.1 channels.</p>Fórmula:C171H245N53O47S6Pureza:98%Cor e Forma:SolidPeso molecular:3987.51NAADP sodium
NAADP sodium is a Ca2+ motor second messenger that targets Ca(2+) channels and can be used to study cancer and immune dysfunction.Fórmula:C21H27N6O18P3Cor e Forma:SolidPeso molecular:744.39PD 0299685
CAS:PD 0299685 is a potent α2δ ligand of the Ca2+ channel for the treatment of interstitial cystitis.Fórmula:C10H21NO2Pureza:97.20%Cor e Forma:SoildPeso molecular:187.28D-myo-Inositol-1,3-diphosphate (sodium salt)
CAS:<p>D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is an inositol phosphate involved in cellular signal transduction.</p>Fórmula:C6H12Na2O12P2Cor e Forma:SolidPeso molecular:384.08G-Glu-Ser
CAS:G-Glu-Ser is a calcium receptor activator and Flavor-enriching agent.Fórmula:C8H14N2O6Cor e Forma:SolidPeso molecular:234.21Nesiritide
CAS:Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.Fórmula:C143H244N50O42S4Pureza:98%Cor e Forma:SolidPeso molecular:3464.04(±)5(6)-DiHETE
CAS:Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.472NAADP tetrasodium salt
CAS:Ca2+ mobilizing agentFórmula:C21H27N6O18P3Pureza:98%Cor e Forma:SolidPeso molecular:744.39Chlorocresol
CAS:Chlorocresol (4-Chloro-3-methylphenol) is an antiseptic medication.Fórmula:C7H7ClOCor e Forma:SolidPeso molecular:142.58Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate
CAS:ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate inhibits NAD(P)H: quinone oxidoreductase 1.Fórmula:C12H10ClNO3Pureza:99.17%Cor e Forma:SolidPeso molecular:251.67D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
CAS:Ins(1,3,4,5)-P4, made via Ins(1,4,5)P3 phosphorylation, boosts calcium by opening ER and plasma membrane channels.Fórmula:C6H8Na8O18P4Cor e Forma:SolidPeso molecular:675.93Ryanodine
CAS:Ryanodine: a diterpenoid modulating Ca2+ release via ryanodine receptors; concentration-dependent effects; found in Ryania speciosa; toxic.Fórmula:C25H35NO9Pureza:98%Cor e Forma:White SolidPeso molecular:493.553ω-Agatoxin IVA
CAS:Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.Fórmula:C217H360N68O60S10Pureza:98%Cor e Forma:SolidPeso molecular:5202.25Katacalcin
CAS:Katacalcin (PDN 21) is a potent plasma calcium-lowering peptide[1].Fórmula:C97H154N34O36S2Pureza:98%Cor e Forma:White PowderPeso molecular:2436.6ω-Agatoxin TK
CAS:<p>Selective blocker of CaV2.1 P/Q-type calcium channels.</p>Fórmula:C215H337N65O70S10Pureza:98%Cor e Forma:SolidPeso molecular:5273.02Levamlodipine besylate Hemipentahydrate
CAS:Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.Fórmula:C20H25ClN2O5·C6H6O3SH2OCor e Forma:SolidPeso molecular:1224.18Ziconotide
CAS:Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.Fórmula:C102H172N36O32S7Pureza:98%Cor e Forma:White PowderPeso molecular:2639.13ILS-920
CAS:ILS-920, a Rapamycin analog, has reduced immunosuppression, enhanced neuroprotection, and preferentially binds FKBP52 and L-type VGCC β1.Fórmula:C57H86N2O14Pureza:98%Cor e Forma:SolidPeso molecular:1023.3Cavα2δ-IN-1
CAS:Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a KiFórmula:C18H27N5OCor e Forma:SolidPeso molecular:329.448SNX-482
CAS:Potent CaV2.3 calcium channel blocker, selective, voltage-dependent, with 30 nM IC50. Offers antinociceptive effects on C and Aδ fibres.Fórmula:C192H274N52O60S7Pureza:98%Cor e Forma:SolidPeso molecular:4495.01ω-Conotoxin MVIIC
CAS:Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.Fórmula:C106H178N40O32S7Pureza:98%Cor e Forma:White Lyophilised SolidPeso molecular:2749Calcium Ionophore I
CAS:Calcium Ionophore I has a wide range of applications in life science related research.Fórmula:C38H72N2O8Cor e Forma:SolidPeso molecular:685.0Mipsagargin
CAS:Mipsagargin (G-202) is a new antibiotic that inhibits DNA biosynthesis.Fórmula:C66H100N6O27Pureza:98%Cor e Forma:SolidPeso molecular:1409.52BTT-266
CAS:<p>BTT-266 is a blocker of voltage-gated calcium channel for pain management.</p>Fórmula:C34H28N4O4Pureza:98.34%Cor e Forma:SolidPeso molecular:556.61Mast cell degranulating peptide (28-49)
CAS:<p>Mast cell degranulating peptide (28-49) is a bee venom depolarizer that can improve the cGMP content of cerebellum tablets in mice.</p>Fórmula:C110H196N40O24S4Pureza:98%Cor e Forma:SolidPeso molecular:2591.25
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