Canais de Cálcio
Os canais de cálcio são proteínas de membrana que regulam o fluxo de íons de cálcio para dentro e fora das células, o que é essencial para várias funções celulares, incluindo a contração muscular, a liberação de neurotransmissores e a expressão gênica. A desregulação da atividade dos canais de cálcio está associada a condições como hipertensão, arritmias cardíacas e distúrbios neurológicos. Na CymitQuimica, oferecemos uma ampla seleção de moduladores de canais de cálcio para apoiar sua pesquisa em saúde cardiovascular, neurobiologia e transdução de sinais.
Foram encontrados 541 produtos de "Canais de Cálcio"
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Mibefradil
CAS:<p>Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).</p>Fórmula:C29H38FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:495.63CAD204520
CAS:CAD204520 functions as an inhibitor of SERCA (IC50 = 0.34 μM), specifically targeting mutations in the wild-type NOTCH1 protein associated with T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL).Fórmula:C23H32F3N3O2Cor e Forma:SolidPeso molecular:439.51IAA65
CAS:IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].Fórmula:C16H13F6NO2Cor e Forma:SolidPeso molecular:365.27Cav 3.1 blocker 1
CAS:Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel inhibitor with an IC50 value of 160 nM for Cav3.1. It exhibits weaker inhibition on Cav 3.2 with an IC50 of 5000 nM and shows no inhibitory effect on Cav 3.3 and Cav 1.2 (IC50 > 10000 nM).Fórmula:C26H19F6N3O2Peso molecular:519.438Emopamil
CAS:Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.Fórmula:C23H30N2Cor e Forma:SolidPeso molecular:334.5Sesamodil
CAS:<p>Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.</p>Fórmula:C29H32N2O6SPureza:98.58% - 99.01%Cor e Forma:SolidPeso molecular:536.64T-Type calcium channel inhibitor 2
Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) & HCT-116 cells (IC50: 6.4μM).Fórmula:C36H39FN4OSCor e Forma:SolidPeso molecular:594.78Leualacin
CAS:Leualacin is a novel calcium blocker from Hapsidospora irregularis.Fórmula:C31H47N3O7Pureza:98%Cor e Forma:SolidPeso molecular:573.72TTA-P1
CAS:TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.Fórmula:C19H27Cl2FN2OCor e Forma:SolidPeso molecular:389.33(rel)-Mirogabalin
CAS:(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.Fórmula:C12H19NO2Cor e Forma:SolidPeso molecular:209.28Calpain Inhibitor-2
CAS:Calpain Inhibitor-2: Lipophilic, moderates growth of A-375, B-16F1, PC-3 cancers, and hinders 80% DU-145 cell invasion.Fórmula:C26H33N3O5SCor e Forma:SolidPeso molecular:499.62SR 33805 oxalate
CAS:Ca2+ channel antagonistFórmula:C34H42N2O9SPureza:98%Cor e Forma:SolidPeso molecular:654.77AZD 2066 hydrate
AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].Fórmula:C19H18ClN5O3Cor e Forma:SolidPeso molecular:386.33PD-217014
CAS:PD-217014 is an α2δ ligand that exhibits visceral analgesic activity and can suppress visceral hypersensitivity. Its antihyperalgesic effects are dose-dependent.Fórmula:C10H17NO2Cor e Forma:SolidPeso molecular:183.25Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.Fórmula:C32H37N3O2Cor e Forma:SolidPeso molecular:495.66Mibefradil dihydrochloride hydrate
CAS:Mibefradil dihydrochloride hydrate is a long-acting antihypertensive blocking high-voltage L calcium channels.Fórmula:C29H42Cl2FN3O4Cor e Forma:SolidPeso molecular:586.57MP-010
CAS:<p>MP-010 is an FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. It facilitates functional improvement in SOD1G93A mice with amyotrophic lateral sclerosis (ALS), evidenced by enhanced motor coordination, increased integrity of neuromuscular junctions, and significantly higher spinal motor neuron survival rates. MP-010 is applicable for research in the field of neurological disorders.</p>Fórmula:C14H20N4O2SCor e Forma:SolidPeso molecular:308.399BER-5
CAS:BER-5 is a potent MrgX2 antagonist, demonstrating broad-spectrum antagonistic activity against various MrgX2 agonists. It can inhibit Substance P(SP)-induced degranulation in LAD2 cells and alleviate SP-induced allergic reactions in mice. BER-5 is useful for researching mechanisms related to allergic reactions.Fórmula:C20H16O4Cor e Forma:SolidPeso molecular:320.34Verapamil EP Impurity C hydrochloride
CAS:NSC-609249 hydrochloride, an impurity of Verapamil, is a calcium channel blocker with potent orally active properties. It also functions as a first-generation P-glycoprotein (P-gp) inhibitor.Fórmula:C12H20ClNO2Cor e Forma:SolidPeso molecular:245.75(Rac)-PD0299685
CAS:<p>(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.</p>Fórmula:C10H21NO2Pureza:97.20%Cor e Forma:SolidPeso molecular:187.28
