PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 188 produtos para "PDE".
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Z21115
CAS:Z21115 is an orally effective phosphodiesterase 4 (PDE4) inhibitor that can inhibit PDE4D7 with an IC50 of 10.5 nM. It suppresses the expression of IL-6, TNF-α, and iNOS induced by Lipopolysaccharide. In a DSS-induced mouse colitis model, Z21115 demonstrates anti-inflammatory activity without significant toxicity at doses up to 1 g/kg.Fórmula:C20H20F2N2O4Peso molecular:390.38GSK4394835A
CAS:GSK4394835A is a reversible covalent inhibitor of PDE3B, with a pIC50 of 6.2. This compound is useful for research in cardiovascular diseases.Fórmula:C27H26BN3O6Peso molecular:499.33Ensifentrine tosylate
CAS:Ensifentrine (RPL-554) tosylate is an inhaled dual inhibitor of PDE3 and PDE4, with IC50 values of 0.4 nM and 1479 nM, respectively. By blocking these enzymes, it increases the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, leading to bronchodilation and inhibition of inflammatory cell activation and migration. Ensifentrine tosylate is used in the study of chronic obstructive pulmonary disease (COPD).Fórmula:C33H39N5O7SPeso molecular:649.76LT-104A
CAS:LT-104A is a potent PDE4 inhibitor that elevates intracellular cAMP levels (EC50 = 1.9 μM) and inhibits PDE4D3 activity (IC50 = 9.3 μM). It activates the cAMP-PKA-CREB anti-inflammatory pathway and suppresses NF-κB-related gene expression (Il1b and Nos2), making it applicable for research in inflammation-related diseases.Fórmula:C33H34O7Peso molecular:542.63PDE5-IN-15
CAS:PDE5-IN-15 (compound 21) is a xanthine derivative and PDE5 inhibitor with IC50 values of 0.002 μM for hPDE5, 0.180 μM for bPDE6, 2.85 μM for bPDE1, and 2.22 μM for hPDE3. It exhibits good oral bioavailability in dogs and is applicable in research related to male erectile dysfunction.Fórmula:C21H23N5O3Peso molecular:393.44PDE11A modulator-1
CAS:PDE11A modulator-1 is a regulator of PDE11A.Fórmula:C20H16N4O2Peso molecular:344.37PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:99.97%Cor e Forma:Yellow SolidPeso molecular:476.55Vizenpistat
CAS:Vizenpistat is an ENPP1 inhibitor utilized in tumor research.Fórmula:C15H21N5O4SCor e Forma:SolidPeso molecular:367.42
