PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Foram encontrados 166 produtos de "PDE"
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Autotaxin-IN-5
CAS:<p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Fórmula:C30H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:547.61Gisadenafil
CAS:<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Cor e Forma:SolidPeso molecular:519.62PDE5-IN-2
CAS:<p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>Fórmula:C25H21N3O6SPureza:98%Cor e Forma:SolidPeso molecular:491.52CI-1044
CAS:<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Fórmula:C23H19N5O2Cor e Forma:SolidPeso molecular:397.43BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Fórmula:C28H31F6NO3Pureza:98.03%Cor e Forma:SolidPeso molecular:543.54Gisadenafil besylate
CAS:<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Fórmula:C29H39N7O8S2Cor e Forma:SolidPeso molecular:677.79Difamilast
CAS:<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Fórmula:C23H24F2N2O5Pureza:99.64%Cor e Forma:SolidPeso molecular:446.44Siguazodan
CAS:<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Fórmula:C14H16N6OPureza:99.62% - 99.87%Cor e Forma:SolidPeso molecular:284.32Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Fórmula:C16H14N4OPureza:99.52% - >99.99%Cor e Forma:SolidPeso molecular:278.31Autotaxin-IN-4
CAS:<p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Fórmula:C22H21N9O2Pureza:98%Cor e Forma:SolidPeso molecular:443.46PF-04957325
CAS:<p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>Fórmula:C14H15F3N8OSPureza:99.02%Cor e Forma:SolidPeso molecular:400.38Enpp-1-IN-16
CAS:<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Fórmula:C23H32N4O4Pureza:99.87%Cor e Forma:SolidPeso molecular:428.52AMG 579
CAS:<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Fórmula:C25H23N5O3Pureza:99.87%Cor e Forma:SolidPeso molecular:441.48Cudetaxestat
CAS:<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Cor e Forma:SolidPeso molecular:482.33TP-10
CAS:<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Fórmula:C26H19F3N4OPureza:99.21%Cor e Forma:SolidPeso molecular:460.45TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Fórmula:C24H35N5O3Pureza:>99.99%Cor e Forma:SolidPeso molecular:441.57PDE9-IN-(S)-C33
CAS:<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Fórmula:C18H20ClN5OPureza:98.75%Cor e Forma:SolidPeso molecular:357.84Thioquinapiperifil dihydrochloride
CAS:<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Fórmula:C24H29ClN6OSPureza:98.73%Cor e Forma:SolidPeso molecular:485.05PF-00489791
CAS:<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Fórmula:C20H28N8O4SPureza:99.97%Cor e Forma:SolidPeso molecular:476.55Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Fórmula:C30H40Cl2N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:683.71
