Glucoquinase
A glucocinase (GK) é uma enzima que catalisa a fosforilação da glicose em glicose-6-fosfato, um passo crítico na glicólise. A GK é predominantemente expressa no fígado e no pâncreas, onde desempenha um papel fundamental na regulação dos níveis de glicose no sangue. Inibidores de GK são de grande interesse no estudo de distúrbios metabólicos como o diabetes, pois podem modular o metabolismo da glicose e a secreção de insulina. Na CymitQuimica, oferecemos inibidores de glucocinase para apoiar sua pesquisa em diabetes, metabolismo e desenvolvimento terapêutico.
Foram encontrados 56 produtos de "Glucoquinase"
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GKA-22
CAS:GKA-22 is a human glucokinase allosteric activator in the absence of glucose.Fórmula:C22H22N2O5SPureza:98%Cor e Forma:SolidPeso molecular:426.49AMG-1694
CAS:AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.Fórmula:C23H30F3N3O4S2Pureza:98.37%Cor e Forma:SolidPeso molecular:533.63CM-10-18
CAS:CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.Fórmula:C17H35NO5Cor e Forma:SolidPeso molecular:333.46AZD-1656
CAS:AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2Fórmula:C24H26N6O5Pureza:97.07% - 99.37%Cor e Forma:SolidPeso molecular:478.5AZD1092
CAS:AZD1092 is the glucokinase enzyme activator.Fórmula:C24H26N4O5Pureza:98%Cor e Forma:SolidPeso molecular:450.49AR453588
CAS:AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Fórmula:C25H25N7O2S2Cor e Forma:SolidPeso molecular:519.64PF-04937319
CAS:PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.Fórmula:C22H20N6O4Pureza:99.89%Cor e Forma:SolidPeso molecular:432.43KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Fórmula:C25H26N6OPureza:98%Cor e Forma:SolidPeso molecular:426.51AR453588 hydrochloride
CAS:AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Fórmula:C25H26ClN7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:556.1WAY-297848
CAS:WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.Fórmula:C13H13ClN2O2SPureza:98.19%Cor e Forma:SolidPeso molecular:296.77Glucokinase activator 7
CAS:Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].Fórmula:C14H13N3O2SCor e Forma:SolidPeso molecular:287.337GKA50 quarterhydrate
GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.Fórmula:C26H30N2O7Cor e Forma:SolidPeso molecular:469.01Gcase activator 2
CAS:Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.Fórmula:C21H24N4O2Pureza:99.51% - 99.76%Cor e Forma:SolidPeso molecular:364.44Glucokinase activator 8
CAS:Glucokinase activator8 is an activator of glucose kinase (glucokinase).Fórmula:C14H13N3O2SCor e Forma:SolidPeso molecular:287.337MK-0941
CAS:MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.Fórmula:C22H28N4O9S2Cor e Forma:SolidPeso molecular:556.61GKA50
CAS:GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).Fórmula:C26H28N2O6Pureza:98%Cor e Forma:SolidPeso molecular:464.51
