Glucoquinase
A glucocinase (GK) é uma enzima que catalisa a fosforilação da glicose em glicose-6-fosfato, um passo crítico na glicólise. A GK é predominantemente expressa no fígado e no pâncreas, onde desempenha um papel fundamental na regulação dos níveis de glicose no sangue. Inibidores de GK são de grande interesse no estudo de distúrbios metabólicos como o diabetes, pois podem modular o metabolismo da glicose e a secreção de insulina. Na CymitQuimica, oferecemos inibidores de glucocinase para apoiar sua pesquisa em diabetes, metabolismo e desenvolvimento terapêutico.
Foram encontrados 56 produtos de "Glucoquinase"
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(E)-3PO
CAS:(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.Fórmula:C13H10N2OPureza:98.8% - 98.92%Cor e Forma:SolidPeso molecular:210.23AMG-3969
CAS:AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).Fórmula:C21H20F6N4O3SPureza:99.65%Cor e Forma:SolidPeso molecular:522.46Ref: TM-TQ0055
1mg52,00€5mg111,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg289,00€50mg399,00€100mg532,00€200mg740,00€Globalagliatin
CAS:Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.Fórmula:C28H37N3O3S3Pureza:98% - 99.56%Cor e Forma:SolidPeso molecular:559.81Genz-123346 free base
CAS:Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.Fórmula:C24H38N2O4Pureza:99.41%Cor e Forma:SolidPeso molecular:418.57AM-2394
CAS:AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.Fórmula:C22H25N5O4Pureza:99.01% - 99.62%Cor e Forma:SolidPeso molecular:423.46Ref: TM-T3312
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg66,00€25mg105,00€50mg172,00€100mg264,00€200mg394,00€3PO
CAS:3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.
Fórmula:C13H10N2OPureza:99.56% - 99.67%Cor e Forma:SolidPeso molecular:210.23Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Fórmula:C16H30O2Pureza:99.76%Cor e Forma:SolidPeso molecular:254.41ML198
CAS:ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.Fórmula:C17H14N4OPureza:98.31%Cor e Forma:SolidPeso molecular:290.32Ref: TM-T8986
2mg46,00€1mL*10mM (DMSO)80,00€5mg92,00€10mg124,00€25mg241,00€50mg360,00€100mg537,00€200mg710,00€YZ9
CAS:Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].Fórmula:C12H10O5Pureza:99.59%Cor e Forma:SolidPeso molecular:234.2Piragliatin
CAS:Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.Fórmula:C19H20ClN3O4SCor e Forma:SolidPeso molecular:421.9Glucokinase activator 1
CAS:Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).Fórmula:C27H20F2N2O7S2Pureza:98%Cor e Forma:SolidPeso molecular:586.58IHVR-11029
CAS:IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.Fórmula:C18H27F2NO5Cor e Forma:SolidPeso molecular:375.41GKA-71
CAS:GKA-71 is an effective glucokinase activator (GKA).Fórmula:C21H23N3O6S2Cor e Forma:SolidPeso molecular:477.55Glucokinase activator 3
CAS:Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.Fórmula:C26H33N2O9PS2Cor e Forma:SolidPeso molecular:612.65PF-04279405
CAS:PF-04279405 is a potent and selective glucokinase activator.Fórmula:C25H25FN4O4Cor e Forma:SolidPeso molecular:464.49PSN-GK1
CAS:PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).Fórmula:C20H23FN2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:438.54Sinogliatin
CAS:Sinogliatin, a glucokinase activator, is used potentially for the treatment of type 2 diabetes.Fórmula:C22H27ClN4O5Cor e Forma:SolidPeso molecular:462.93(R)-PF-04991532
(R)-PF-04991532 is the R-enantiomer of PF-04991532 . PF-04991532 is a potent, hepatoselective glucokinase activator .Fórmula:C18H19F3N4O3Cor e Forma:SolidPeso molecular:396.36Cefetrizole
CAS:Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).Fórmula:C16H15N5O4S3Pureza:98%Cor e Forma:SolidPeso molecular:437.52RO-28-1675
CAS:RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.Fórmula:C18H22N2O3S2Pureza:98.13%Cor e Forma:SolidPeso molecular:378.51Ref: TM-T16793
1mg59,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg191,00€25mg386,00€50mg623,00€100mg947,00€200mg1.324,00€
