Glucoquinase
A glucocinase (GK) é uma enzima que catalisa a fosforilação da glicose em glicose-6-fosfato, um passo crítico na glicólise. A GK é predominantemente expressa no fígado e no pâncreas, onde desempenha um papel fundamental na regulação dos níveis de glicose no sangue. Inibidores de GK são de grande interesse no estudo de distúrbios metabólicos como o diabetes, pois podem modular o metabolismo da glicose e a secreção de insulina. Na CymitQuimica, oferecemos inibidores de glucocinase para apoiar sua pesquisa em diabetes, metabolismo e desenvolvimento terapêutico.
Foram encontrados 53 produtos de "Glucoquinase"
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3PO
CAS:<p>3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.</p>Fórmula:C13H10N2OPureza:99.56% - 99.67%Cor e Forma:SolidPeso molecular:210.23Palmitelaidic Acid
CAS:<p>Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.</p>Fórmula:C16H30O2Pureza:99.76%Cor e Forma:SolidPeso molecular:254.41(E)-3PO
CAS:<p>(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.</p>Fórmula:C13H10N2OPureza:98.8% - 98.92%Cor e Forma:SolidPeso molecular:210.23PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Fórmula:C17H12N2OPureza:99.7% - 99.85%Cor e Forma:SolidPeso molecular:260.29Genz-123346 free base
CAS:<p>Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.</p>Fórmula:C24H38N2O4Pureza:99.41%Cor e Forma:SolidPeso molecular:418.57AMG-3969
CAS:<p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>Fórmula:C21H20F6N4O3SPureza:99.65%Cor e Forma:SolidPeso molecular:522.46Glucokinase activator 3
CAS:<p>Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.</p>Fórmula:C26H33N2O9PS2Cor e Forma:SolidPeso molecular:612.65RO-28-1675
CAS:<p>RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.</p>Fórmula:C18H22N2O3S2Pureza:98.13%Cor e Forma:SolidPeso molecular:378.51PSN-GK1
CAS:<p>PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).</p>Fórmula:C20H23FN2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:438.54GKA-22
CAS:<p>GKA-22 is a human glucokinase allosteric activator in the absence of glucose.</p>Fórmula:C22H22N2O5SPureza:98%Cor e Forma:SolidPeso molecular:426.49Piragliatin
CAS:<p>Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.</p>Fórmula:C19H20ClN3O4SCor e Forma:SolidPeso molecular:421.9Glucokinase activator 1
CAS:<p>Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).</p>Fórmula:C27H20F2N2O7S2Pureza:98%Cor e Forma:SolidPeso molecular:586.58IHVR-11029
CAS:<p>IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.</p>Fórmula:C18H27F2NO5Cor e Forma:SolidPeso molecular:375.41GKA-71
CAS:<p>GKA-71 is an effective glucokinase activator (GKA).</p>Fórmula:C21H23N3O6S2Cor e Forma:SolidPeso molecular:477.55PF-04279405
CAS:<p>PF-04279405 is a potent and selective glucokinase activator.</p>Fórmula:C25H25FN4O4Cor e Forma:SolidPeso molecular:464.49Cefetrizole
CAS:<p>Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).</p>Fórmula:C16H15N5O4S3Pureza:98%Cor e Forma:SolidPeso molecular:437.52YZ9
CAS:<p>Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].</p>Fórmula:C12H10O5Pureza:99.59%Cor e Forma:SolidPeso molecular:234.2AMG-1694
CAS:<p>AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.</p>Fórmula:C23H30F3N3O4S2Pureza:98.37%Cor e Forma:SolidPeso molecular:533.63AR453588
CAS:<p>AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Fórmula:C25H25N7O2S2Cor e Forma:SolidPeso molecular:519.64KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Fórmula:C25H26N6OPureza:98%Cor e Forma:SolidPeso molecular:426.51
