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SGK

SGK

A quinase regulada por soro e glucocorticoides (SGK) é uma proteína quinase envolvida na regulação de vários processos celulares, incluindo transporte de íons, sobrevivência celular e metabolismo da glicose. Os inibidores de SGK são valiosos no estudo de condições como hipertensão, diabetes e câncer, onde a atividade de SGK desempenha um papel crucial. Esses inibidores ajudam a entender as vias de sinalização reguladas por SGK e suas implicações nas doenças. Na CymitQuimica, oferecemos inibidores de SGK para apoiar sua pesquisa em transdução de sinal, doenças metabólicas e terapia contra o câncer.

Foram encontrados 11 produtos para "SGK".

  • SGK1-IN-3 hydrochloride
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    SGK1-IN-3 hydrochloride

    SGK1-IN-3 hydrochloride is an oral SGK1 inhibitor that blocks 尾-catenin activation and shows potential in osteoarthritis.
    Fórmula:C23H21Cl3N6O3S
    Cor e Forma:Solid
    Peso molecular:567.88

    Ref: TM-T210357

  • 308-R-C4-PEG3-C1-Boc
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    308-R-C4-PEG3-C1-Boc

    CAS:
    308-R-C4-PEG3-C1-Boc is an SGK3 ligand-linker conjugate, utilized in the synthesis of PROTAC SGK3 degrader-2.
    Fórmula:C39H53FN6O9S
    Cor e Forma:Solid
    Peso molecular:800.94

    Ref: TM-T212100

  • SGK1-IN-4
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    SGK1-IN-4

    CAS:
    SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.
    Fórmula:C23H21ClFN5O4S
    Pureza:97.03%
    Cor e Forma:Solid
    Peso molecular:517.96

    Ref: TM-T9977

  • SI-113
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    SI-113

    CAS:
    SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
    Fórmula:C23H24N6O
    Pureza:98.93%
    Cor e Forma:Solid
    Peso molecular:400.4763

    Ref: TM-T9589

  • CKI-7
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    CKI-7

    CAS:
    CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.
    Fórmula:C11H14Cl3N3O2S
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:358.67

    Ref: TM-T19913

  • GSK 650394
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    GSK 650394

    CAS:
    GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.
    Fórmula:C25H22N2O2
    Pureza:97.46% - >99.99%
    Cor e Forma:White Solid
    Peso molecular:382.45

    Ref: TM-T2622

  • EMD638683
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    EMD638683

    CAS:
    EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).
    Fórmula:C18H18F2N2O4
    Pureza:98%
    Cor e Forma:White Solid
    Peso molecular:364.3433

    Ref: TM-T6635

  • SGK1-IN-1
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    SGK1-IN-1

    CAS:
    SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor
    Fórmula:C17H12ClFN6O2S
    Pureza:97.44%
    Cor e Forma:Solid
    Peso molecular:418.833

    Ref: TM-T12890

  • EMD638683 R-Form
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    EMD638683 R-Form

    CAS:
    EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
    Fórmula:C18H18F2N2O4
    Cor e Forma:Solid
    Peso molecular:364.3433

    Ref: TM-T11181

  • Logotipo do CymitQuimica
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    SGK1-IN-8

    CAS:
    SGK1-IN-8 (compound 55) is an inhibitor of SGK1 and GSK3β, exhibiting an IC50 of 0.11 μM for human SGK1 and 3.39 μM for human GSK3β. It reduces the catalytic activity of both SGK1 and GSK3β and decreases the phosphorylation level of TAU protein at the Ser214 site. SGK1-IN-8 is applicable in Alzheimer's disease research.
    Fórmula:C18H13ClN4O
    Peso molecular:336.78

    Ref: TM-T219117

  • SGK1-IN-6
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    SGK1-IN-6

    CAS:
    SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.
    Fórmula:C30H30F3N5O4
    Cor e Forma:Solid
    Peso molecular:581.586

    Ref: TM-T205289