Aminopeptidase
As aminopeptidases são um grupo de enzimas que catalisam a clivagem de aminoácidos a partir do N-terminal de peptídeos e proteínas, desempenhando um papel crucial na maturação e degradação de proteínas. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo o processamento de antígenos, a regulação de hormônios peptídicos e a homeostase celular. Inibidores de aminopeptidases são de interesse no tratamento de doenças como câncer, inflamação e doenças infecciosas. Na CymitQuimica, oferecemos uma variedade de inibidores de aminopeptidases para apoiar sua pesquisa em proteômica, desenvolvimento de medicamentos e tratamento de doenças.
Foram encontrados 75 produtos de "Aminopeptidase"
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Bufexamac
CAS:Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Fórmula:C12H17NO3Pureza:99.73%Cor e Forma:Acicular CrystalPeso molecular:223.27ERAP1-IN-1
CAS:ERAP1-IN-1 inhibits and allosterically activates ERAP1, affecting fluorogenic, chromogenic, and nonamer peptide substrates.Fórmula:C20H21F3N2O5SPureza:98.95%Cor e Forma:SolidPeso molecular:458.45JNJ-40929837 succinate
CAS:JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].Fórmula:C22H24N4O2S·xC4H6O4Cor e Forma:SolidBDM_92499
BDM_92499 is a nanomolar, selective IRAP inhibitor with an IC50 of 3.4 nM. It also inhibits ERAP1 and ERAP2, with IC50 values of 0.46 μM and 4.2 μM, respectively.Cor e Forma:Odour SolidERAP1-IN-3
ERAP1-IN-3 (compound 13) is a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), with a pIC50 value of 8.6. ERAP1-IN-3 shows potential for research in cancer immunotherapy and autoimmune disease studies.Fórmula:C22H22N2O4SCor e Forma:SolidPeso molecular:410.49LTA4H-IN-4
<p>LTA4H-IN-4 (compound 3) is an orally active inhibitor of LTA4H. It exhibits an IC50 value of 156 μM against hERG and is applicable for inflammation-related research.</p>Antho-rwamide I
CAS:Antho-rwamide I is an anthozoan neuropeptide.Fórmula:C31H46N10O7Cor e Forma:SolidPeso molecular:670.76Probestin
CAS:Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.Fórmula:C26H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:502.60LYS006 hydrochloride
CAS:LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 value of 2 nM. It is applicable in the study of inflammatory and autoimmune diseases. For further details, please refer to compound 29 in patent document WO2015092740A1.Fórmula:C16H15Cl2FN6O3Cor e Forma:SolidPeso molecular:429.23ERAP1 modulator-1
CAS:ERAP1 modulator-1 (Compound 1) is a regulator of endoplasmic reticulum aminopeptidase 1 (ERAP1) with an IC50 of less than 250 nM.Fórmula:C23H23F3N2O5SCor e Forma:SolidPeso molecular:496.5Matlystatin A
CAS:Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.Fórmula:C27H47N5O8SCor e Forma:SolidPeso molecular:601.76SDUY817
<p>SDUY817 is a dual APN/NEP inhibitor with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. It exhibits analgesic effects in a concentration- and time-dependent manner, making it a potential candidate for research in the field of neuropathic pain disorders.</p>Fórmula:C18H16IN3O3Cor e Forma:SolidPeso molecular:449.24SDUY816
<p>SDUY816 is an orally active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. It exhibits analgesic properties and demonstrates good safety and pharmacokinetic profiles, having an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral, 10 mg/kg). SDUY816 is applicable for research in the field of neuropathic pain disorders.</p>Fórmula:C18H16IN3O3Cor e Forma:SolidPeso molecular:449.24Leuhistin
CAS:Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.Fórmula:C11H19N3O3Pureza:98%Cor e Forma:White To Off-White SolidPeso molecular:241.29Aminopeptidase N inhibitor 2
<p>AminopeptidaseN inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor properties.</p>Fórmula:C12H16F2N2O4SCor e Forma:SolidPeso molecular:322.07988NGR peptide Trifluoroacetate
NGR peptide Trifluoroacetate contains an NGR motif recognized by CD13/APN in tumor neovasculature, used for targeted drug delivery in cancer research.Fórmula:C22H37F3N10O10S2Pureza:99.69%Cor e Forma:SolidPeso molecular:722.72α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
CAS:α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aidedFórmula:C23H23NO3Pureza:97.19% - 99.36%Cor e Forma:SoildPeso molecular:361.43Aclimostat
CAS:Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.Fórmula:C26H42N2O6Cor e Forma:SolidPeso molecular:478.63Relzomostat
CAS:Relzomostat inhibits MetAP2, with research potential for obesity and type 2 diabetes.Fórmula:C24H36F2N2O5Cor e Forma:SolidPeso molecular:470.558CD13-IN-1
<p>CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.</p>Cor e Forma:Odour SolidH-Val-βNA
CAS:H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.Fórmula:C15H18N2OCor e Forma:SolidPeso molecular:242.322Amastatin hydrochloride
CAS:Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.Fórmula:C21H39ClN4O8Cor e Forma:White To Off-White PowderPeso molecular:511.01Lys-psi(CH2NH)-trp(nps)-ome
CAS:Lys-psi(CH2NH)-trp(nps)-ome peptide bond replaced by CH2NH group.Fórmula:C24H31N5O4SCor e Forma:SolidPeso molecular:485.60BAY-277
<p>BAY-277 is a degrader of METAP2, with IC50 values of 5.8 nM for human METAP2 (hMETAP2) and 5.9 nM for mouse METAP2 (mMETAP2).</p>Fórmula:C44H52N8O5Cor e Forma:SolidPeso molecular:772.93DG013A formate
DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.Fórmula:C27H37N4O4PCH2O2Cor e Forma:SolidPeso molecular:530.99ecMetAP-IN-1
CAS:ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。Fórmula:C13H11N3Pureza:99.34%Cor e Forma:SolidPeso molecular:209.25NGR peptide
CAS:Cell-penetrating peptideFórmula:C20H36N10O8S2Pureza:98%Cor e Forma:SolidPeso molecular:608.69Apstatin TFA
<p>Apstatin TFA is a potent inhibitor of aminopeptidase P (APP), with Ki values of 2.6 µM for rat APP and 0.64 µM for human APP. This compound also exhibits cardioprotective properties.</p>Fórmula:C25H34F3N5O7Cor e Forma:SolidPeso molecular:573.56HFI-142
CAS:HFI-142 is a inhibitor to aminopeptidase N; inhibit leukotriene A4 biosynthesis in red blood cells; inhibit dditional aminopeptidases.Fórmula:C17H16N2O4Cor e Forma:SolidPeso molecular:312.32L(+)-Leucinol
CAS:L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.Fórmula:C6H15NOPureza:98%Cor e Forma:Clear Colorless To Slightly Yellow LiquidPeso molecular:117.19Methyl arachidate
CAS:<p>Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid</p>Fórmula:C21H42O2Pureza:≥95%Cor e Forma:White PowderPeso molecular:326.56DG051
CAS:DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).Fórmula:C21H25Cl2NO4Pureza:98.26%Cor e Forma:SolidPeso molecular:426.33Bestatin trifluoroacetate
CAS:Bestatin trifluoroacetate inhibits CD13/APN and leukotriene A4 hydrolase, used in cancer research.Fórmula:C18H25F3N2O6Cor e Forma:SolidPeso molecular:422.401N-Acetyl-β-Asp-Glu
CAS:N-Acetyl-β-Asp-Glu is a peptide neurotransmitter, the third most common neurotransmitter in the mammalian nervous system.Fórmula:C11H16N2O8Pureza:99.94%Cor e Forma:SolidPeso molecular:304.25Bestatin hydrochloride
CAS:<p>Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.</p>Fórmula:C16H25ClN2O4Pureza:98% - 99.93%Cor e Forma:SolidPeso molecular:344.84Tosedostat
CAS:Tosedostat (CHR-2797), an oral M1 aminopeptidase inhibitor, turns into CHR-79888, blocks tumor cell proteins, causing cell death.Fórmula:C21H30N2O6Pureza:98.14% - 99.4%Cor e Forma:SolidPeso molecular:406.47Acebilustat
CAS:<p>Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.</p>Fórmula:C29H27N3O4Pureza:99.59% - 99.88%Cor e Forma:SolidPeso molecular:481.54Adamantanine
CAS:Adamantanine (NSC-145160) is an amino acid transport inhibitor.Fórmula:C11H17NO2Pureza:99.79%Cor e Forma:SolidPeso molecular:195.26Puromycin aminonucleoside
CAS:Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.Fórmula:C12H18N6O3Pureza:99.85% - 99.9%Cor e Forma:SolidPeso molecular:294.31ARM1
CAS:ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.Fórmula:C16H14N2SPureza:99.36%Cor e Forma:SolidPeso molecular:266.36Firibastat
CAS:<p>Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33.</p>Fórmula:C8H20N2O6S4Pureza:99.5%Cor e Forma:SolidPeso molecular:368.51DG-051
CAS:DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis.Fórmula:C21H24ClNO4Cor e Forma:SolidPeso molecular:389.87SC-57461A
CAS:SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.Fórmula:C20H26ClNO3Pureza:99.91%Cor e Forma:SolidPeso molecular:363.9Bestatin
CAS:Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.Fórmula:C16H24N2O4Pureza:98% - 99.63%Cor e Forma:White Crystalline PowderPeso molecular:308.37SC-22716
CAS:SC-22716 is a LTA4 hydrolase inhibitor.SC-22716 has anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis.Fórmula:C18H21NOPureza:99.91%Cor e Forma:SolidPeso molecular:267.37Aminopeptidase-IN-1
CAS:Aminopeptidase-IN-1: potent IRAP blocker, Ki 7.7 μM, useful for cognitive/memory disorder research.Fórmula:C18H16N2O6Pureza:98.34%Cor e Forma:SolidPeso molecular:356.33Acetyltrialanine
CAS:Acetyltrialanine is a dipeptide compound that binds at two sites on the Tb+3-pancreatic elastase complex and can be used as a nitrogen source.Fórmula:C11H19N3O5Pureza:97.03%Cor e Forma:White PowderPeso molecular:273.29Amastatin
CAS:Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 μM .Fórmula:C21H38N4O8Pureza:98%Cor e Forma:SolidPeso molecular:474.55BDM14471
CAS:BDM14471 is a selective inhibitor of hydroxamate PfAM1.Fórmula:C17H15FN2O3Pureza:98%Cor e Forma:SolidPeso molecular:314.31TP-004
CAS:TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).Fórmula:C17H16F3N5OPureza:98%Cor e Forma:SolidPeso molecular:363.34M8891
CAS:M8891: Oral, reversible MetAP-2 inhibitor, brain-penetrant (IC50: 54nM; Ki: 4.33nM), hinders endothelial & tumor cell growth, antiangiogenic & antitumor.Fórmula:C20H17F2N3O3Cor e Forma:SolidPeso molecular:385.36HFI-437
CAS:HFI-437 is a potent, non-peptidic, insulin-regulated aminopeptidase (IRAP) inhibitor with a K i of 20 nM and functions as a cognitive enhancer [1].Fórmula:C23H20N2O5Cor e Forma:SolidPeso molecular:404.42Leucinal
CAS:Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.Fórmula:C6H13NOCor e Forma:SolidPeso molecular:115.17Anticancer agent 51
CAS:Compound 3d (Anticancer agent 51) has a Ki of 731.62 nM, showing promise for prostate cancer research.Fórmula:C22H20F3N3O2SCor e Forma:SolidPeso molecular:447.47ERAP2-IN-1
CAS:ERAP2-IN-1 is a specific non-competitive ERAP2 inhibitor with IC50s of 27 μM for Arg-AMC and 44 μM for peptides.Fórmula:C20H21F3N2O5SCor e Forma:SolidPeso molecular:458.45JNJ-26993135
CAS:JNJ-26993135 is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor.Fórmula:C20H20N2O3SCor e Forma:SolidPeso molecular:368.45Aminopeptidase N Inhibitor
CAS:AP-N inhibitor: reversible, selective for AP-N/CD13 (IC50=25 μM), non-toxic to U937 cells at 100 μM.Fórmula:C17H10N2O8Cor e Forma:SolidPeso molecular:370.27LYS006
CAS:LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor,for neutrophil-driven inflammatory diseases ulcerative colitis.Fórmula:C16H14ClFN6O3Pureza:99.33%Cor e Forma:SoildPeso molecular:392.77RB 101
CAS:RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.Fórmula:C31H38N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:582.84MetAP2-IN-1
CAS:MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].Fórmula:C8H6BrN3Pureza:98%Cor e Forma:SolidPeso molecular:224.06JNJ-40929837
CAS:JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.Fórmula:C22H24N4O2SCor e Forma:SolidPeso molecular:408.52PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Fórmula:C22H36N2O6Cor e Forma:SolidPeso molecular:424.53Beloranib
CAS:Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.Fórmula:C29H41NO6Pureza:98%Cor e Forma:SolidPeso molecular:499.644-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Fórmula:C14H14OCor e Forma:SolidPeso molecular:198.26ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.505Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Fórmula:C16H24N4O3Cor e Forma:SolidPeso molecular:320.387TNP-470
CAS:<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Fórmula:C19H28ClNO6Pureza:98%Cor e Forma:SolidPeso molecular:401.88SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Fórmula:C23H38N2O5Peso molecular:422.56Bestatin methyl ester
CAS:Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.Fórmula:C17H26N2O4Cor e Forma:SolidPeso molecular:322.4LTA4H-IN-2
CAS:LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].Fórmula:C20H19FN6O2Cor e Forma:SolidPeso molecular:394.4LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Fórmula:C17H15ClN4O3Cor e Forma:SolidPeso molecular:358.78QGC583
CAS:QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.Fórmula:C13H20NO5PCor e Forma:SolidPeso molecular:301.28EC33
CAS:EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].Fórmula:C4H11NO3S2Cor e Forma:SolidPeso molecular:185.27Ketomethylenebestatin
CAS:Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.Fórmula:C17H25NO4Pureza:98%Cor e Forma:SolidPeso molecular:307.38A-800141
CAS:A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.Fórmula:C24H30N2O4SCor e Forma:SolidPeso molecular:442.571
