Aminopeptidase
As aminopeptidases são um grupo de enzimas que catalisam a clivagem de aminoácidos a partir do N-terminal de peptídeos e proteínas, desempenhando um papel crucial na maturação e degradação de proteínas. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo o processamento de antígenos, a regulação de hormônios peptídicos e a homeostase celular. Inibidores de aminopeptidases são de interesse no tratamento de doenças como câncer, inflamação e doenças infecciosas. Na CymitQuimica, oferecemos uma variedade de inibidores de aminopeptidases para apoiar sua pesquisa em proteômica, desenvolvimento de medicamentos e tratamento de doenças.
Foram encontrados 67 produtos de "Aminopeptidase"
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Leucinal
CAS:<p>Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.</p>Fórmula:C6H13NOCor e Forma:SolidPeso molecular:115.17M8891
CAS:<p>M8891: Oral, reversible MetAP-2 inhibitor, brain-penetrant (IC50: 54nM; Ki: 4.33nM), hinders endothelial & tumor cell growth, antiangiogenic & antitumor.</p>Fórmula:C20H17F2N3O3Cor e Forma:SolidPeso molecular:385.36HFI-437
CAS:<p>HFI-437 is a potent, non-peptidic, insulin-regulated aminopeptidase (IRAP) inhibitor with a K i of 20 nM and functions as a cognitive enhancer [1].</p>Fórmula:C23H20N2O5Cor e Forma:SolidPeso molecular:404.42Amastatin
CAS:<p>Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 μM .</p>Fórmula:C21H38N4O8Pureza:98%Cor e Forma:SolidPeso molecular:474.55Aminopeptidase-IN-1
CAS:<p>Aminopeptidase-IN-1: potent IRAP blocker, Ki 7.7 μM, useful for cognitive/memory disorder research.</p>Fórmula:C18H16N2O6Pureza:98.37%Cor e Forma:SolidPeso molecular:356.33SC-22716
CAS:<p>SC-22716 is a LTA4 hydrolase inhibitor.SC-22716 has anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis.</p>Fórmula:C18H21NOPureza:99.91%Cor e Forma:SolidPeso molecular:267.37TP-004
CAS:<p>TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).</p>Fórmula:C17H16F3N5OPureza:98%Cor e Forma:SolidPeso molecular:363.34BDM14471
CAS:<p>BDM14471 is a selective inhibitor of hydroxamate PfAM1.</p>Fórmula:C17H15FN2O3Pureza:98%Cor e Forma:SolidPeso molecular:314.31LYS006
CAS:<p>LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor,for neutrophil-driven inflammatory diseases ulcerative colitis.</p>Fórmula:C16H14ClFN6O3Pureza:99.33%Cor e Forma:SoildPeso molecular:392.77JNJ-40929837
CAS:<p>JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.</p>Fórmula:C22H24N4O2SCor e Forma:SolidPeso molecular:408.52RB 101
CAS:<p>RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.</p>Fórmula:C31H38N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:582.84MetAP2-IN-1
CAS:<p>MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].</p>Fórmula:C8H6BrN3Pureza:98%Cor e Forma:SolidPeso molecular:224.06Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Fórmula:C16H24N4O3Cor e Forma:SolidPeso molecular:320.387A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Fórmula:C24H30N2O4SCor e Forma:SolidPeso molecular:442.571EC33
CAS:<p>EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].</p>Fórmula:C4H11NO3S2Cor e Forma:SolidPeso molecular:185.27LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Fórmula:C17H15ClN4O3Cor e Forma:SolidPeso molecular:358.78LTA4H-IN-2
CAS:<p>LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].</p>Fórmula:C20H19FN6O2Cor e Forma:SolidPeso molecular:394.4Bestatin methyl ester
CAS:<p>Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.</p>Fórmula:C17H26N2O4Cor e Forma:SolidPeso molecular:322.4Ketomethylenebestatin
CAS:<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Fórmula:C17H25NO4Pureza:98%Cor e Forma:SolidPeso molecular:307.38SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Fórmula:C23H38N2O5Peso molecular:422.56
