Aminopeptidase
As aminopeptidases são um grupo de enzimas que catalisam a clivagem de aminoácidos a partir do N-terminal de peptídeos e proteínas, desempenhando um papel crucial na maturação e degradação de proteínas. Essas enzimas estão envolvidas em vários processos fisiológicos, incluindo o processamento de antígenos, a regulação de hormônios peptídicos e a homeostase celular. Inibidores de aminopeptidases são de interesse no tratamento de doenças como câncer, inflamação e doenças infecciosas. Na CymitQuimica, oferecemos uma variedade de inibidores de aminopeptidases para apoiar sua pesquisa em proteômica, desenvolvimento de medicamentos e tratamento de doenças.
Foram encontrados 83 produtos para "Aminopeptidase".
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ERAP2-IN-1
CAS:ERAP2-IN-1 is a non-competitive inhibitor of endoplasmic reticulum aminopeptidase 2 (ERAP2).Fórmula:C20H21F3N2O5SPureza:99.58%Cor e Forma:White SolidPeso molecular:458.45Ref: TM-T62861
1mg54,00€5mg114,00€1mL*10mM (DMSO)114,00€10mg178,00€25mg409,00€50mg710,00€100mg1.153,00€JNJ-26993135
CAS:JNJ-26993135 is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor.Fórmula:C20H20N2O3SCor e Forma:SolidPeso molecular:368.45SC-22716
CAS:SC-22716 is a LTA4 hydrolase inhibitor.SC-22716 has anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis.Fórmula:C18H21NOPureza:99.91%Cor e Forma:SolidPeso molecular:267.37TP-004
CAS:TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).Fórmula:C17H16F3N5OPureza:98%Cor e Forma:SolidPeso molecular:363.34MetAP2-IN-1
CAS:MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].Fórmula:C8H6BrN3Pureza:98%Cor e Forma:SolidPeso molecular:224.057JNJ-40929837
CAS:JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.Fórmula:C22H24N4O2SCor e Forma:SolidPeso molecular:408.52Ketomethylenebestatin
CAS:Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.Fórmula:C17H25NO4Pureza:98%Cor e Forma:SolidPeso molecular:307.38PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Fórmula:C22H36N2O6Cor e Forma:SolidPeso molecular:424.53EC33
CAS:EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].Fórmula:C4H11NO3S2Cor e Forma:SolidPeso molecular:185.27A-800141
CAS:A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.Fórmula:C24H30N2O4SCor e Forma:SolidPeso molecular:442.5714-MDM
CAS:4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.Fórmula:C14H14OCor e Forma:SolidPeso molecular:198.26LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Fórmula:C17H15ClN4O3Cor e Forma:SolidPeso molecular:358.78RB 101
CAS:RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.Fórmula:C31H38N2O3S3Pureza:98%Cor e Forma:SolidPeso molecular:582.84Arphamenine A
CAS:Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).Fórmula:C16H24N4O3Cor e Forma:SolidPeso molecular:320.387DG013A
CAS:DG013A inhibits ERAP1 & ERAP2 (IC50: 33 nM & 11 nM) to research autoimmune diseases & cancer.Fórmula:C27H37N4O4PCor e Forma:SolidPeso molecular:512.58SDX-7539
CAS:SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.Fórmula:C23H38N2O5Cor e Forma:SolidPeso molecular:422.56Bestatin methyl ester
CAS:Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.Fórmula:C17H26N2O4Cor e Forma:SolidPeso molecular:322.4TNP-470
CAS:TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.Fórmula:C19H28ClNO6Pureza:98%Cor e Forma:SolidPeso molecular:401.88LTA4H-IN-2
CAS:LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].Fórmula:C20H19FN6O2Cor e Forma:SolidPeso molecular:394.4QGC583
CAS:QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.Fórmula:C13H20NO5PCor e Forma:SolidPeso molecular:301.28
