Caseína quinase
As caseína quinases são uma família de proteínas quinases serina/treonina que regulam vários processos celulares, incluindo a reparação do DNA, os ritmos circadianos e a transdução de sinais. Essas quinases estão envolvidas na fosforilação de numerosas proteínas e estão implicadas em doenças como o câncer, distúrbios neurodegenerativos e síndromes metabólicas. Na CymitQuimica, oferecemos uma seleção de inibidores de caseína quinase para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 143 produtos para "Caseína quinase".
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NMS-P715
CAS:NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).Fórmula:C35H39F3N8O3Pureza:99.84%Cor e Forma:SolidPeso molecular:676.73Ellagic acid
CAS:Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.Fórmula:C14H6O8Pureza:97.11% - 99.75%Cor e Forma:Brown SolidPeso molecular:302.19Silmitasertib sodium salt
CAS:Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Fórmula:C19H11ClN3NaO2Pureza:99.49% - 99.95%Cor e Forma:SolidPeso molecular:371.75A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Cor e Forma:SolidPeso molecular:321.22Emodin
CAS:Emodin (Frangula emodin) is a selective 11β-HSD1 inhibitor,IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice. High-Quality, Low-Cost!Fórmula:C15H10O5Pureza:98.37% - 99.53%Cor e Forma:SolidPeso molecular:270.24CK2-IN-15
CK2-IN-15 (Compound Biv5) is a selective and potent inhibitor of the enzyme protein kinase CK2, with an IC50 value of 51 pM. It significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also decreases viral replication in an in vitro model of human nasal epithelial cells. CK2-IN-15 holds potential for research into diseases related to β-coronavirus infections.Cor e Forma:Odour SolidAH081
AH081 (Compound 38) is a CK1δ/ε PROTAC degrader and serves as the negative control for AH078. It maintains inhibitory activity against CK1δ/ε but lacks degradation activity due to the use of an inactive stereoisomer of the VHL ligand.Cor e Forma:Odour SolidAc-ESMD-CHO
CAS:Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (Fórmula:C19H30N4O10SPureza:98%Cor e Forma:SolidPeso molecular:506.53GSK-3β/CK-1δ-IN-1
GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.Fórmula:C22H17F3N4OCor e Forma:SolidPeso molecular:410.39Casein Kinase Substrates 3
CAS:Casein Kinase Substrates 3 is a substrate of casein kinase.Fórmula:C85H139N27O35SPureza:98%Cor e Forma:SolidPeso molecular:2131.24CK1-IN-4
CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.Cor e Forma:Odour SolidCasein kinase 1δ-IN-9
CAS:Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.Fórmula:C15H12ClN3Pureza:99.93%Cor e Forma:White SolidPeso molecular:269.73Ref: TM-T64376
1mg64,00€1mL*10mM (DMSO)124,00€5mg136,00€10mg197,00€25mg314,00€50mg424,00€100mg562,00€200mg743,00€CK2-IN-14
CK2-IN-14 (Compound 10b) is an inhibitor of cyclin-dependent kinase 2α with an IC50 of 36.7 nM. It effectively hinders the growth of cancer cell lines 786-O and U937, with GI50 values of 7.3 μM and 7.5 μM, respectively.Fórmula:C19H20ClN5SCor e Forma:SolidPeso molecular:385.91Casein kinase 1δ-IN-8
CAS:Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.Fórmula:C19H14FN5OSPureza:99.56%Cor e Forma:SolidPeso molecular:379.41Casein kinase 1δ-IN-6
CAS:CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.Fórmula:C16H10ClF3N2OSPureza:99.87%Cor e Forma:SolidPeso molecular:370.78Ellagic acid (hydrate)
CAS:Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).Fórmula:C14H8O9Pureza:98%Cor e Forma:SolidPeso molecular:320.21Casein kinase 1δ-IN-3
CAS:Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.Fórmula:C17H16N2O2SPureza:98.94%Cor e Forma:SoildPeso molecular:312.39TBCA
CAS:TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.Fórmula:C9H4Br4O2Pureza:99.3%Cor e Forma:SolidPeso molecular:463.74CK1-IN-3
CAS:WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.Fórmula:C17H16N2O3SPureza:99.18%Cor e Forma:SolidPeso molecular:328.39Ref: TM-T60005
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg96,00€25mg170,00€50mg244,00€100mg334,00€200mg460,00€QXG-6442
QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.Fórmula:C21H17N5O4Cor e Forma:SolidPeso molecular:403.39Casein
CAS:Casein is a milk protein with multiple roles involved in novel drug delivery systems.Pureza:95%Cor e Forma:SolidWAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.Fórmula:C11H12N2O2S2Pureza:99.53%Cor e Forma:SolidPeso molecular:268.36Casein kinase 1δ-IN-15
CAS:Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].Fórmula:C19H17FN6OCor e Forma:SolidPeso molecular:364.38CK2-IN-13
CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.Fórmula:C19H13Br2NO3Cor e Forma:SolidPeso molecular:463.119CK1δ/CK1ε liagnd-1
CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.Fórmula:C21H20F2N6Cor e Forma:SolidPeso molecular:394.42CSNK2-IN-2
CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.Fórmula:C25H30FN9OCor e Forma:SolidPeso molecular:491.56Casein kinase 1δ-IN-14
CAS:Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.Fórmula:C17H11ClN4O2Pureza:99.66%Cor e Forma:SolidPeso molecular:338.75WAY-353591
CAS:WAY-353591 is a casein kinase 1d (CK1d) inhibitor IC₅₀ of 131 μM. WAY-353591 can be used in pathological studies of neurodegenerative diseases.Fórmula:C16H12FN3SPureza:99.98%Cor e Forma:White SolidPeso molecular:297.35MU1742
MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .Fórmula:C22H22F2N6Cor e Forma:SolidPeso molecular:408.45Casein kinase 1δ-IN-7
CAS:Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.Fórmula:C17H14N4O2SPureza:98.02%Cor e Forma:SolidPeso molecular:338.38AH078
AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.Fórmula:C51H60F2N10O5SCor e Forma:SolidPeso molecular:963.15CZP-IN-1
CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.Fórmula:C20H26N4O4SCor e Forma:SolidPeso molecular:418.51Casein Kinase 2 Substrate Peptide
CAS:CK2 Substrate Peptide, C-terminus linked to EDANS, used for CK2 activity assays.Fórmula:C45H73N19O24Cor e Forma:SolidPeso molecular:1264.17MRT00033659
CAS:MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.Fórmula:C15H14N4OCor e Forma:SolidPeso molecular:266.3PF-5006739
CAS:PF-5006739 is a selective CK1δ/ε inhibitor for psychiatric disorder and metabolic research.Fórmula:C22H22FN7OPureza:98%Cor e Forma:SolidPeso molecular:419.45FPFT-2216
CAS:FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.Fórmula:C12H12N4O3SPureza:99.35% - 99.62%Cor e Forma:SolidPeso molecular:292.31Ref: TM-T60608
1mg92,00€5mg222,00€1mL*10mM (DMSO)236,00€10mg334,00€25mg708,00€50mg1.108,00€100mg1.783,00€200mg2.412,00€SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Fórmula:C20H21N7OPureza:99.41%Cor e Forma:SolidPeso molecular:375.43PF-670462
CAS:PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Cor e Forma:SolidPeso molecular:410.32SR-3029
CAS:SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.Fórmula:C23H19F3N8OPureza:99.64%Cor e Forma:SolidPeso molecular:480.45CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:White SolidPeso molecular:383.39Ref: TM-T5393
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg152,00€25mg289,00€50mg447,00€100mg670,00€Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33LY-364947
CAS:LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.Fórmula:C17H12N4Pureza:99.65% - 99.96%Cor e Forma:Yellow SolidPeso molecular:272.3Ref: TM-T2048
5mg62,00€1mL*10mM (DMSO)69,00€10mg78,00€25mg136,00€50mg241,00€100mg354,00€200mg530,00€500mg830,00€TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Cor e Forma:SolidPeso molecular:434.71CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H14Cl3N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:358.67(E/Z)-GO289
CAS:(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.Fórmula:C17H15BrN4O2SPureza:98.1%Cor e Forma:SolidPeso molecular:419.3Ref: TM-T9356
2mg34,00€5mg52,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg170,00€50mg250,00€100mg354,00€200mg482,00€Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Fórmula:C19H12ClN3O2Pureza:98% - 99.90%Cor e Forma:SolidPeso molecular:349.77Ref: TM-T2259
1mg38,00€2mg49,00€5mg80,00€1mL*10mM (DMSO)88,00€10mg118,00€25mg197,00€50mg313,00€100mg492,00€500mg1.054,00€TAK-715
CAS:TAK-715 is a p38 MAPK inhibitor for p38α.Fórmula:C24H21N3OSPureza:99.83%Cor e Forma:White SolidPeso molecular:399.51Ref: TM-T6150
1mg38,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)92,00€10mg94,00€25mg166,00€50mg306,00€100mg480,00€IWP-2
CAS:IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.Fórmula:C22H18N4O2S3Pureza:96.1% - 99.49%Cor e Forma:White SolidPeso molecular:466.6Umbralisib
CAS:Umbralisib (TGR 1202) is a PI3Kδ inhibitor.Fórmula:C31H24F3N5O3Pureza:99.56% - 99.56%Cor e Forma:White SolidPeso molecular:571.55Ref: TM-T4976
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)114,00€10mg166,00€25mg324,00€50mg425,00€100mg623,00€DMAT
CAS:DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).Fórmula:C9H7Br4N3Pureza:99.48%Cor e Forma:White SolidPeso molecular:476.79
