Caseína quinase
As caseína quinases são uma família de proteínas quinases serina/treonina que regulam vários processos celulares, incluindo a reparação do DNA, os ritmos circadianos e a transdução de sinais. Essas quinases estão envolvidas na fosforilação de numerosas proteínas e estão implicadas em doenças como o câncer, distúrbios neurodegenerativos e síndromes metabólicas. Na CymitQuimica, oferecemos uma seleção de inibidores de caseína quinase para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 130 produtos de "Caseína quinase"
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Emodin
CAS:<p>Emodin (Frangula emodin) is a selective 11β-HSD1 inhibitor,IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice. High-Quality, Low-Cost!</p>Fórmula:C15H10O5Pureza:98.37% - 99.53%Cor e Forma:Physical Description Orange Needles Or Powder (Ntp 1992)Peso molecular:270.24Ellagic acid
CAS:<p>Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.</p>Fórmula:C14H6O8Pureza:97.11% - 99.75%Cor e Forma:Cream Colored Needles From Pyridine 1992)Peso molecular:302.19A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Fórmula:C12H14Cl2N2O2SPureza:99.32%Cor e Forma:SolidPeso molecular:321.22Silmitasertib sodium salt
CAS:<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Fórmula:C19H11ClN3NaO2Pureza:99.49% - 99.62%Cor e Forma:SolidPeso molecular:371.75NMS-P715
CAS:<p>NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).</p>Fórmula:C35H39F3N8O3Pureza:99.84%Cor e Forma:SolidPeso molecular:676.73GSK-3β/CK-1δ-IN-1
<p>GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.</p>Fórmula:C22H17F3N4OCor e Forma:SolidPeso molecular:410.39MU1742
<p>MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .</p>Fórmula:C22H22F2N6Cor e Forma:SolidPeso molecular:408.45Casein kinase 1δ-IN-6
CAS:<p>CK1δ-IN-6: potent, selective CK-1δ inhibitor, IC50 23 nM, neuroprotective, anti-inflammatory, for neurodegenerative research.</p>Fórmula:C16H10ClF3N2OSPureza:99%Cor e Forma:SoildPeso molecular:370.78CSNK2-IN-2
<p>CSNK2-IN-2 (compound 2) is an orally active inhibitor of CSNK2. It is utilized in antiviral research.</p>Fórmula:C25H30FN9OCor e Forma:SolidPeso molecular:491.56CK2-IN-14
<p>CK2-IN-14 (Compound 10b) is an inhibitor of cyclin-dependent kinase 2α with an IC50 of 36.7 nM. It effectively hinders the growth of cancer cell lines 786-O and U937, with GI50 values of 7.3 μM and 7.5 μM, respectively.</p>Fórmula:C19H20ClN5SCor e Forma:SolidPeso molecular:385.91Casein Kinase 2 Substrate Peptide
CAS:<p>CK2 Substrate Peptide, C-terminus linked to EDANS, used for CK2 activity assays.</p>Fórmula:C45H73N19O24Cor e Forma:SolidPeso molecular:1264.17WAY-297174
CAS:<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Fórmula:C11H12N2O2S2Pureza:99.53%Cor e Forma:SoildPeso molecular:268.36Casein kinase 1δ-IN-15
CAS:<p>Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].</p>Fórmula:C19H17FN6OCor e Forma:SolidPeso molecular:364.38QXG-6442
<p>QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.</p>Fórmula:C21H17N5O4Cor e Forma:SolidPeso molecular:403.39CK1-IN-3
CAS:<p>WAY-296817 inhibits CK1, potential for circadian rhythm and inflammation research.</p>Fórmula:C17H16N2O3SPureza:99.18%Cor e Forma:SolidPeso molecular:328.39CK1-IN-4
<p>CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.</p>Cor e Forma:Odour SolidCasein kinase 1δ-IN-3
CAS:<p>Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.</p>Fórmula:C17H16N2O2SPureza:98.94%Cor e Forma:SoildPeso molecular:312.39Casein kinase 1δ-IN-9
CAS:<p>Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.</p>Fórmula:C15H12ClN3Pureza:99.93%Cor e Forma:SolidPeso molecular:269.73Casein kinase 1δ-IN-7
CAS:<p>Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C17H14N4O2SPureza:98.6%Cor e Forma:SolidPeso molecular:338.38Casein kinase 1δ-IN-8
CAS:<p>Casein kinase 1δ-IN-8 is an inhibitor of casein kinase 1δ and is used to treat neurodegenerative diseases such as Alzheimer's disease type.</p>Fórmula:C19H14FN5OSPureza:99.66%Cor e Forma:SolidPeso molecular:379.41CK2-IN-13
<p>CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.</p>Fórmula:C19H13Br2NO3Cor e Forma:SolidPeso molecular:463.119Casein
CAS:<p>Casein is a milk protein with multiple roles involved in novel drug delivery systems.</p>Pureza:95%Cor e Forma:SoildCasein Kinase Substrates 3
CAS:<p>Casein Kinase Substrates 3 is a substrate of casein kinase.</p>Fórmula:C85H139N27O35SPureza:98%Cor e Forma:SolidPeso molecular:2131.24TBCA
CAS:<p>TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.</p>Fórmula:C9H4Br4O2Pureza:99.3%Cor e Forma:SolidPeso molecular:463.74Ellagic acid (hydrate)
CAS:<p>Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).</p>Fórmula:C14H8O9Pureza:98%Cor e Forma:Green To Beige PowderPeso molecular:320.21Casein kinase 1δ-IN-14
CAS:<p>Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.</p>Fórmula:C17H11ClN4O2Pureza:99.74%Cor e Forma:SolidPeso molecular:338.75CIGB-300
CAS:<p>CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by disrupting the phosphorylation activity of protein kinase CK2. The compound induces apoptosis in various tumor cell lines, making it valuable for research in cancer therapy.</p>Fórmula:C127H215N53O30S3Cor e Forma:SolidPeso molecular:3060.6CZP-IN-1
<p>CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.</p>Fórmula:C20H26N4O4SCor e Forma:SolidPeso molecular:418.51CK1δ/CK1ε liagnd-1
<p>CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.</p>Fórmula:C21H20F2N6Cor e Forma:SolidPeso molecular:394.42AH078
<p>AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.</p>Fórmula:C51H60F2N10O5SCor e Forma:SolidPeso molecular:963.15FPFT-2216
CAS:<p>FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.</p>Fórmula:C12H12N4O3SPureza:99.35% - 99.62%Cor e Forma:SolidPeso molecular:292.31MRT00033659
CAS:<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>Fórmula:C15H14N4OCor e Forma:SolidPeso molecular:266.3SGC-CK2-1
CAS:<p>SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.</p>Fórmula:C20H21N7OPureza:99.41%Cor e Forma:SolidPeso molecular:375.43PF-5006739
CAS:<p>PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.</p>Fórmula:C22H22FN7OPureza:98%Cor e Forma:SolidPeso molecular:419.45TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Cor e Forma:SolidPeso molecular:351.32SR-3029
CAS:<p>SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.</p>Fórmula:C23H19F3N8OPureza:99.64%Cor e Forma:SolidPeso molecular:480.45PF-670462
CAS:<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Cor e Forma:SolidPeso molecular:410.32CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:SolidPeso molecular:383.39Longdaysin
CAS:<p>Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).</p>Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33TTP 22
CAS:<p>TTP 22: ATP-competitive CK2 inhibitor; IC50/Ki: 0.1 μM/40 nM; >250x selective over JNK3, ROCK1, MET.</p>Fórmula:C16H14N2O2S2Pureza:97.08% - 97.78%Cor e Forma:SolidPeso molecular:330.42TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Cor e Forma:Off-White SolidPeso molecular:434.71NCC007
CAS:<p>NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.</p>Fórmula:C22H28F3N7Pureza:98.88%Cor e Forma:SolidPeso molecular:447.5MLN8054
CAS:<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Cor e Forma:SolidPeso molecular:476.86(E/Z)-GO289
CAS:<p>(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2.</p>Fórmula:C17H15BrN4O2SPureza:98.1%Cor e Forma:SolidPeso molecular:419.3AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Fórmula:C14H8FNO4SPureza:99.06% - 99.09%Cor e Forma:SolidPeso molecular:305.28Umbralisib hydrochloride
CAS:<p>Umbralisib hydrochloride: PI3Kδ inhibitor; IC50=22.2 nM, EC50=24.3 nM; active vs CK1ε, EC50=6.0 μM.</p>Fórmula:C31H25ClF3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:608.01CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Fórmula:C11H14Cl3N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:358.67DMAT
CAS:<p>DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).</p>Fórmula:C9H7Br4N3Pureza:99.48%Cor e Forma:SolidPeso molecular:476.79TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Fórmula:C24H21N3OSPureza:99.83%Cor e Forma:SolidPeso molecular:399.51
