Caseína quinase
As caseína quinases são uma família de proteínas quinases serina/treonina que regulam vários processos celulares, incluindo a reparação do DNA, os ritmos circadianos e a transdução de sinais. Essas quinases estão envolvidas na fosforilação de numerosas proteínas e estão implicadas em doenças como o câncer, distúrbios neurodegenerativos e síndromes metabólicas. Na CymitQuimica, oferecemos uma seleção de inibidores de caseína quinase para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 143 produtos para "Caseína quinase".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
GSK-3β/CK-1δ-IN-1
GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.Fórmula:C22H17F3N4OCor e Forma:SolidPeso molecular:410.39Ac-ESMD-CHO
CAS:Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (Fórmula:C19H30N4O10SPureza:98%Cor e Forma:SolidPeso molecular:506.53WAY-353591
CAS:WAY-353591 is a casein kinase 1d (CK1d) inhibitor IC₅₀ of 131 μM. WAY-353591 can be used in pathological studies of neurodegenerative diseases.Fórmula:C16H12FN3SPureza:99.98%Cor e Forma:White SolidPeso molecular:297.35TBCA
CAS:TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.Fórmula:C9H4Br4O2Pureza:99.3%Cor e Forma:SolidPeso molecular:463.74Casein kinase 1δ-IN-9
CAS:Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.Fórmula:C15H12ClN3Pureza:99.93%Cor e Forma:White SolidPeso molecular:269.73Ref: TM-T64376
1mg64,00€1mL*10mM (DMSO)124,00€5mg136,00€10mg197,00€25mg314,00€50mg424,00€100mg562,00€200mg743,00€Casein Kinase Substrates 3
CAS:Casein Kinase Substrates 3 is a substrate of casein kinase.Fórmula:C85H139N27O35SPureza:98%Cor e Forma:SolidPeso molecular:2131.24CK1-IN-4
CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.Cor e Forma:Odour SolidCK2-IN-15
CK2-IN-15 (Compound Biv5) is a selective and potent inhibitor of the enzyme protein kinase CK2, with an IC50 value of 51 pM. It significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also decreases viral replication in an in vitro model of human nasal epithelial cells. CK2-IN-15 holds potential for research into diseases related to β-coronavirus infections.Cor e Forma:Odour SolidCK2-IN-13
CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.Fórmula:C19H13Br2NO3Cor e Forma:SolidPeso molecular:463.119CK1δ/CK1ε liagnd-1
CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.Fórmula:C21H20F2N6Cor e Forma:SolidPeso molecular:394.42Casein kinase 1δ-IN-15
CAS:Casein kinase 1δ-IN-15, an inhibitor for casein kinase 1 (CK1δ), exhibits an IC50 of 0.045 μM [1].Fórmula:C19H17FN6OCor e Forma:SolidPeso molecular:364.38CZP-IN-1
CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.Fórmula:C20H26N4O4SCor e Forma:SolidPeso molecular:418.51Casein kinase 1δ-IN-14
CAS:Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.Fórmula:C17H11ClN4O2Pureza:99.66%Cor e Forma:SolidPeso molecular:338.75FPFT-2216
CAS:FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.Fórmula:C12H12N4O3SPureza:99.35% - 99.62%Cor e Forma:SolidPeso molecular:292.31Ref: TM-T60608
1mg92,00€5mg222,00€1mL*10mM (DMSO)236,00€10mg334,00€25mg708,00€50mg1.108,00€100mg1.783,00€200mg2.412,00€SGC-CK2-1
CAS:SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.Fórmula:C20H21N7OPureza:99.41%Cor e Forma:SolidPeso molecular:375.43PF-5006739
CAS:PF-5006739 is a selective CK1δ/ε inhibitor for psychiatric disorder and metabolic research.Fórmula:C22H22FN7OPureza:99.96%Cor e Forma:SolidPeso molecular:419.45MRT00033659
CAS:MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.Fórmula:C15H14N4OCor e Forma:SolidPeso molecular:266.3PF-670462
CAS:PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Cor e Forma:SolidPeso molecular:410.32CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:White SolidPeso molecular:383.39Ref: TM-T5393
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg152,00€25mg289,00€50mg447,00€100mg670,00€Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33
