Caseína quinase
As caseína quinases são uma família de proteínas quinases serina/treonina que regulam vários processos celulares, incluindo a reparação do DNA, os ritmos circadianos e a transdução de sinais. Essas quinases estão envolvidas na fosforilação de numerosas proteínas e estão implicadas em doenças como o câncer, distúrbios neurodegenerativos e síndromes metabólicas. Na CymitQuimica, oferecemos uma seleção de inibidores de caseína quinase para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 130 produtos de "Caseína quinase"
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CK1-IN-4
<p>CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.</p>Cor e Forma:Odour SolidCasein kinase 1δ-IN-9
CAS:<p>Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.</p>Fórmula:C15H12ClN3Pureza:99.93%Cor e Forma:SolidPeso molecular:269.73Casein kinase 1δ-IN-7
CAS:<p>Casein kinase 1δ-IN-7 is a Casein kinase 1δ inhibitor for neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C17H14N4O2SPureza:98.6%Cor e Forma:SolidPeso molecular:338.38WAY-297174
CAS:<p>WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.</p>Fórmula:C11H12N2O2S2Pureza:99.53%Cor e Forma:SoildPeso molecular:268.36Casein Kinase 2 Substrate Peptide
CAS:<p>CK2 Substrate Peptide, C-terminus linked to EDANS, used for CK2 activity assays.</p>Fórmula:C45H73N19O24Cor e Forma:SolidPeso molecular:1264.17Casein Kinase Substrates 3
CAS:<p>Casein Kinase Substrates 3 is a substrate of casein kinase.</p>Fórmula:C85H139N27O35SPureza:98%Cor e Forma:SolidPeso molecular:2131.24QXG-6442
<p>QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.</p>Fórmula:C21H17N5O4Cor e Forma:SolidPeso molecular:403.39CZP-IN-1
<p>CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi protease (CZP) without affecting cathepsin L (IC50=28 nM). This compound is applicable in Chagas disease research.</p>Fórmula:C20H26N4O4SCor e Forma:SolidPeso molecular:418.51Casein kinase 1δ-IN-14
CAS:<p>Casein kinase 1δ-IN-14 (WAY-637081) can be used to study atherosclerosis-related cardiovascular disease.</p>Fórmula:C17H11ClN4O2Pureza:99.74%Cor e Forma:SolidPeso molecular:338.75AH078
<p>AH078 (compound 37) is a selective PROTAC degrader targeting CK1δ and CK1ε with low selectivity for CK1α. AH078 consists of a PROTAC linker (black part) Monomethyl octanoate, a target protein ligand (red part) CK1δ/CK1ε ligand-1, and an E3 ligase ligand (blue part) E3 Ligase Ligand 58. The E3 ligase ligand combined with the linker forms the conjugate E3 Ligase Ligand-linker Conjugate 163.</p>Fórmula:C51H60F2N10O5SCor e Forma:SolidPeso molecular:963.15SGC-CK2-1
CAS:<p>SGC-CK2-1, a CK2 inhibitor, is a inducer of insulin production and secretion in pancreatic β-cells.</p>Fórmula:C20H21N7OPureza:99.41%Cor e Forma:SolidPeso molecular:375.43FPFT-2216
CAS:<p>FPFT-2216 is a "molecular glue" compound with potential anti-tumor activity that degrades IKZF6, IKZF1, DE1D and can be used to study immune system diseases.</p>Fórmula:C12H12N4O3SPureza:99.35% - 99.62%Cor e Forma:SolidPeso molecular:292.31MRT00033659
CAS:<p>MRT00033659 inhibits CK1 (IC50=0.9 μM), CHK1 (IC50=0.23 μM), activates p53, and destabilizes E2F-1; it's a pyrazolo-pyridine.</p>Fórmula:C15H14N4OCor e Forma:SolidPeso molecular:266.3PF-5006739
CAS:<p>PF-5006739: potent, selective CK1δ/ε inhibitor (IC50: 3.9/17.0 nM); may treat psychiatric disorders, improves glucose tolerance, reduces opioid seeking.</p>Fórmula:C22H22FN7OPureza:98%Cor e Forma:SolidPeso molecular:419.45TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Cor e Forma:SolidPeso molecular:351.32PF-670462
CAS:<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Cor e Forma:SolidPeso molecular:410.32CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Fórmula:C24H15F2N3Pureza:98.79%Cor e Forma:SolidPeso molecular:383.39Longdaysin
CAS:<p>Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).</p>Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Cor e Forma:Off-White SolidPeso molecular:434.71LY294002
CAS:<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Fórmula:C19H17NO3Pureza:98% - 99.96%Cor e Forma:Pale Yellow SolidPeso molecular:307.34
