Receptor de Retinóide
Os receptores de retinoides são receptores nucleares que mediam os efeitos dos retinoides (derivados da vitamina A) na expressão gênica. Esses receptores desempenham um papel vital na diferenciação celular, proliferação e apoptose. Inibidores dos receptores de retinoides são utilizados para estudar seu envolvimento em várias doenças, incluindo câncer, distúrbios de pele e condições metabólicas. Ao modular a atividade dos receptores de retinoides, esses inibidores podem fornecer insights sobre os mecanismos de sinalização dos retinoides e seu potencial terapêutico. Na CymitQuimica, oferecemos inibidores dos receptores de retinoides para apoiar sua pesquisa em dermatologia, oncologia e regulação metabólica.
Foram encontrados 20 produtos para "Receptor de Retinóide".
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RXR agonist 3
RXR agonist 3 (Compound 35) is a potent partial agonist of RXR, showing EC50 values of 3 nM for RXRα, 3 nM for RXRβ, and 8 nM for RXRγ. It is applicable in research related to Alzheimer's disease, multiple sclerosis, and lymphoma.BMS 195614
CAS:BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.Fórmula:C29H24N2O3Pureza:97.14%Cor e Forma:White SolidPeso molecular:448.51CD3254
CAS:CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.Fórmula:C24H28O3Pureza:98.71% - 98.71%Cor e Forma:Yellow SolidPeso molecular:364.48AR7
CAS:AR7 is a retinoic acid receptor α (RARα) antagonist.Fórmula:C15H12ClNOPureza:98.12% - 99.86%Cor e Forma:White SolidPeso molecular:257.715BMS270394
CAS:BMS270394 is a RARγ agonist used in the study of breast cancer and skin diseases.Fórmula:C23H26FNO4Cor e Forma:White SolidPeso molecular:399.46BMS 961
CAS:BMS 961 is an RARγ-selective agonist used to profile coregulator binding signatures and to induce TSLP expression in mouse keratinocytes, supporting research on RARγ transcription and epithelial immune signaling.Fórmula:C23H26FNO4Pureza:98%Cor e Forma:SolidPeso molecular:399.46CD2665
CAS:CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.Fórmula:C31H34O5Pureza:99.71%Cor e Forma:White SolidPeso molecular:486.6MM 11253
CAS:MM 11253 is a RARγ antagonist with IC50 of 44nM.Fórmula:C28H30O2S2Pureza:99.41%Cor e Forma:SolidPeso molecular:462.67BMS 753
CAS:BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).Fórmula:C21H21NO4Pureza:98.55%Cor e Forma:SolidPeso molecular:351.4AC-261066
CAS:AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.Fórmula:C17H20FNO4SPureza:99.64%Cor e Forma:SolidPeso molecular:353.41Ch55
CAS:Ch55, a potent HL60 cell differentiator (EC50=200nM), binds well to RAR-α/β, useful for cancer research.Fórmula:C24H28O3Pureza:99.55%Cor e Forma:SolidPeso molecular:364.48Fluorobexarotene
CAS:Fluorobexarotene, a potent RXR agonist, has 75% higher affinity than Bexarotene with Ki of 12 nM and EC50 of 43 nM for RXRα.Fórmula:C24H27FO2Pureza:99.08%Cor e Forma:SolidPeso molecular:366.4684BMS641
CAS:BMS641 (BMS-209641) is a RARβ agonist with affinity for RARβ that synergistically activates RARβ and RARgamma to induce cell maturation.Fórmula:C27H23ClO2Pureza:98.11%Cor e Forma:SolidPeso molecular:414.92KCL-286
CAS:KCL-286 is an available and potent retinoic acid receptor beta agonist for the amelioration of spinal cord injury (SCI).Fórmula:C19H14N2O4Pureza:99.88%Cor e Forma:SolidPeso molecular:334.33ER 50891
CAS:ER-50891 is a potent RARα antagonist, countering retinoic acid inhibition and aiding BMP2-induced osteoblast differentiation.Fórmula:C29H24N2O2Pureza:99.43%Cor e Forma:SolidPeso molecular:432.51LE135
CAS:LE135: RARα/RARβ antagonist (Ki: 1.4 μM/220 nM), favors RARβ, selective vs RARγ/RXRs; also activates TRPV1/TRPA1 (EC50s: 2.5/20 μM).Fórmula:C29H30N2O2Pureza:97.94%Cor e Forma:SolidPeso molecular:438.56ZSH-2208
CAS:ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.Fórmula:C20H18O3SPureza:99.81%Cor e Forma:SolidPeso molecular:338.42BMS-948
CAS:BMS-948 is a selective RARβ transcriptional agonist with an EC50 of 0.1 μM. It is utilized in research pertaining to tumor diseases, embryonic development, and tissue remodeling.Fórmula:C24H17NO3Peso molecular:367.40LE-540
CAS:LE-540 is a selective retinoic acid receptor β (RARβ) antagonist with a Ki value of 0.22 μM. It shows potential for use in cancer research, particularly in studies focusing on breast and lung cancer.Fórmula:C33H32N2O2Peso molecular:488.63BMS453
CAS:BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin.Fórmula:C27H24O2Pureza:99.93%Cor e Forma:White SolidPeso molecular:380.48
