IDO
A indoleamina 2,3-dioxigenase (IDO) é uma enzima envolvida no catabolismo do triptofano, levando à produção de quinurenina e outros metabólitos. A IDO desempenha um papel na tolerância imunológica e é frequentemente regulada em alta em condições como câncer e inflamações crônicas. Inibidores de IDO estão sendo explorados como potenciais agentes imunoterapêuticos no câncer e em doenças autoimunes. Na CymitQuimica, oferecemos inibidores de IDO para apoiar sua pesquisa em imunologia, oncologia e regulação metabólica.
Foram encontrados 84 produtos de "IDO"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
GNF-PF-3777
CAS:<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Fórmula:C15H7N3O4Pureza:97.88%Cor e Forma:SolidPeso molecular:293.23LY3381916
CAS:IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.Fórmula:C23H25FN2O3Pureza:99.3%Cor e Forma:SolidPeso molecular:396.45Ref: TM-T11901
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg215,00€50mg344,00€100mg540,00€1mL*10mM (DMSO)74,00€IDO-IN-13
CAS:IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).Fórmula:C26H17F3N4OPureza:99.29%Cor e Forma:SolidPeso molecular:458.43Ref: TM-T11616
1mg58,00€5mg113,00€10mg165,00€25mg230,00€50mg338,00€100mg490,00€1mL*10mM (DMSO)131,00€BMT-297376
CAS:BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.Fórmula:C23H29F2N3O3Cor e Forma:SolidPeso molecular:433.5IDO-IN-15
CAS:IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).Fórmula:C29H39N5O4Cor e Forma:SolidPeso molecular:521.662NLG802
CAS:<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Fórmula:C20H30ClN3O3Pureza:99.61%Cor e Forma:SolidPeso molecular:395.92IDO1-IN-11
CAS:<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Fórmula:C22H17ClFN3O3Cor e Forma:SolidPeso molecular:425.84IDO1-IN-7
CAS:IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.Fórmula:C22H19ClFN3O3Cor e Forma:SolidPeso molecular:427.86IDO1/TDO-IN-8
IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.Fórmula:C17H14N2SCor e Forma:SolidPeso molecular:278.37PROTAC IDO1 Degrader-1
CAS:First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.Fórmula:C40H53BrFN9O13Cor e Forma:SolidPeso molecular:966.816CAY10581
CAS:CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50Fórmula:C22H21NO4Cor e Forma:SolidPeso molecular:363.41XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Cor e Forma:Odour Solidhuman TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Fórmula:C30H36N4O5Cor e Forma:SolidPeso molecular:532.631NU227326
CAS:NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).Fórmula:C53H61FN8O7Cor e Forma:SolidPeso molecular:941.099TDO-IN-2
TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.Fórmula:C20H15N3O3Cor e Forma:SolidPeso molecular:345.11134β-Cembrenediol
CAS:β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate.Fórmula:C20H34O2Cor e Forma:SolidPeso molecular:306.49IDO1-IN-23
IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].Pureza:98%Cor e Forma:Odour SolidIDO1/TDO-IN-7
IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.Cor e Forma:Odour SolidIDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Fórmula:C18H22N2O4Peso molecular:330.15796NU223612
CAS:"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."Fórmula:C49H55FN6O9Cor e Forma:SolidPeso molecular:890.99IDO1-IN-12
CAS:IDO1-IN-12 is a potent and orally available IDO1 inhibitor.Fórmula:C21H19F3N2O2Cor e Forma:SolidPeso molecular:388.39IDO1/TDO-IN-4
CAS:IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO.Fórmula:C14H10N4Pureza:98.88%Cor e Forma:SolidPeso molecular:234.26IDO1 Protein, Mouse, Recombinant (His)
IDO Protein, Mouse, Recombinant (His) is expressed in E.Pureza:≥ 90 % as determined by SDS-PAGE. - ≥ 90 % as determined by SDS-PAGE.Cor e Forma:Lyophilized PowderPeso molecular:46.47 kDa (predicted)(Rac)-IDO1-IN-5
CAS:(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.Fórmula:C23H25FN2O3Cor e Forma:SolidPeso molecular:396.45IDO1 Protein, Human, Recombinant (His)
IDO Protein, Human, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:46 kDa (predicted); 44 kDa (reducing conditions)(S)-IDO1-IN-5
CAS:(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 μΜ).Fórmula:C23H25FN2O3Cor e Forma:SolidPeso molecular:396.45Anti-IDO1 Antibody (9Y885)
Anti-IDO1 Antibody (9Y885) is an antibody targeting IDO1. Anti-IDO1 Antibody (9Y885) can be used in ELISA, IHC.Cor e Forma:Odour LiquidIDO1 Protein, Human, Recombinant
IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.Cor e Forma:Lyophilized PowderPeso molecular:45.2 kDa (predicted); 46 kDa (reducing conditions)BMS-986242
CAS:BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.Fórmula:C24H24ClFN2OPureza:98.9%Cor e Forma:SolidPeso molecular:410.91Linrodostat
CAS:Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.Fórmula:C24H24ClFN2OPureza:99.54% - 99.71%Cor e Forma:SolidPeso molecular:410.91(S)-Indoximod
CAS:(S)-Indoximod (L-Abrine) is an indoleamine-2,3-dioxygenase (IDO) inhibitor for cancer research.Fórmula:C12H14N2O2Pureza:95.39% - 99.69%Cor e Forma:SolidPeso molecular:218.253-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Fórmula:C7H6N4Pureza:99.16% - >99.99%Cor e Forma:SolidPeso molecular:146.15Indoximod
CAS:Indoximod (NLG-8189) is a methylated tryptophan that inhibits IDO to boost T cell function by preventing tryptophan depletion.Fórmula:C12H14N2O2Pureza:97.82% - 99.55%Cor e Forma:SolidPeso molecular:218.25IDO-IN-7
CAS:IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.Fórmula:C18H22N2OPureza:99.32% - 99.9%Cor e Forma:SolidPeso molecular:282.38Epacadostat
CAS:Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.Fórmula:C11H13BrFN7O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:438.23Ref: TM-T3548
1g757,00€2g1.035,00€5mg47,00€10mg70,00€25mg87,00€50mg111,00€100mg187,00€200mg311,00€500mg525,00€1mL*10mM (DMSO)50,00€IDO-IN-1
CAS:<p>IDO-IN-1: potent IDO inhibitor, IC50 of 59 nM (enzyme), 12 nM (HeLa cells).</p>Fórmula:C9H7BrFN5O2Pureza:99.91%Cor e Forma:SolidPeso molecular:316.09Navoximod
CAS:Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).Fórmula:C18H21FN2O2Pureza:99.37%Cor e Forma:SolidPeso molecular:316.37Ref: TM-TQ0071
1mg159,00€5mg329,00€10mg495,00€25mg633,00€50mg787,00€100mg1.103,00€1mL*10mM (DMSO)335,00€Linrodostat mesylate
CAS:Linrodostat (BMS-986205) is an oral IDO1 inhibitor that boosts immune response and has anti-cancer properties.Fórmula:C25H28ClFN2O4SPureza:98%Cor e Forma:SolidPeso molecular:507.02IDO1-IN-1
CAS:IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.Fórmula:C7H7N3SPureza:99.36%Cor e Forma:Slightly Yellow To Beige-Green Crystalline PowderPeso molecular:165.22LM10
CAS:TDO inhibitor; IC50: human 0.62 μM, mouse 2 μM; selective over IDO, MAOs; hinders TDO+ tumor growth in mice; orally active.Fórmula:C11H8FN5Pureza:98.78% - 99.94%Cor e Forma:SolidPeso molecular:229.21PCC0208009
CAS:PCC0208009 (IDO-IN-2) is an IDO inhibitor.Fórmula:C29H35N7OPureza:99.89%Cor e Forma:SolidPeso molecular:497.63Ref: TM-T4142
1mg47,00€2mg59,00€5mg87,00€10mg150,00€25mg271,00€50mg464,00€100mg640,00€1mL*10mM (DMSO)97,00€IDO5L
CAS:IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).Fórmula:C9H7ClFN5O2Pureza:99.49% - 99.75%Cor e Forma:SolidPeso molecular:271.64Ref: TM-T2647
10mg50,00€25mg86,00€50mg124,00€100mg187,00€200mg321,00€500mg505,00€1mL*10mM (DMSO)35,00€PF-06840003
CAS:PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.Fórmula:C12H9FN2O2Pureza:99.10%Cor e Forma:SolidPeso molecular:232.21Ref: TM-T4307
2mg35,00€5mg52,00€10mg93,00€25mg107,00€50mg127,00€100mg188,00€200mg283,00€1mL*10mM (DMSO)58,00€Necrostatin 2 racemate
CAS:Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.Fórmula:C13H12ClN3O2Pureza:98% - 99.5%Cor e Forma:SolidPeso molecular:277.71Ref: TM-T7504
1mg65,00€5mg107,00€10mg169,00€25mg305,00€50mg527,00€100mg743,00€500mg1.510,00€1mL*10mM (DMSO)140,00€DP00477
CAS:DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 µM.Fórmula:C17H11ClF3N3OSCor e Forma:SolidPeso molecular:397.8IDO-IN-12
CAS:IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).Fórmula:C13H11BrFN5O3SPureza:99.727%Cor e Forma:SolidPeso molecular:416.23Ref: TM-T11615
1mg88,00€5mg180,00€10mg264,00€25mg416,00€50mg540,00€100mg753,00€1mL*10mM (DMSO)188,00€IACS-8968 S-enantiomer
CAS:IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.35IACS-8968
CAS:IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.35IDO1-IN-18
CAS:IDO1-IN-18 (Compound 14) is a potent inhibitor of IDO1. IDO1-IN-18 has potential for cancer disease research.Fórmula:C23H18F4N2O3Cor e Forma:SolidPeso molecular:446.39IDO-IN-8
CAS:IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Fórmula:C18H21FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.37IDO-IN-6
CAS:IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.Fórmula:C18H21FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.37IDO1-IN-2
CAS:IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.Fórmula:C15H17FN6O4Pureza:98%Cor e Forma:SolidPeso molecular:364.33IDO-IN-3
CAS:IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).Fórmula:C11H12BrFN6O2Cor e Forma:SolidPeso molecular:359.15IDO-IN-11
CAS:IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).Fórmula:C19H23BrFN7O4SPureza:98%Cor e Forma:SolidPeso molecular:544.4IDO1/TDO-IN-3
CAS:IDO1/TDO-IN-3 inhibits IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM) with strong anti-tumor activity and low toxicity.Fórmula:C16H6ClF2N3O2Cor e Forma:SolidPeso molecular:345.69IDO-IN-4
CAS:IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.Fórmula:C26H35N3O3Cor e Forma:SolidPeso molecular:437.57IDO1-IN-16
CAS:IDO1-IN-16 (I-1) is an IDO1 inhibitor that targets holo-IDO1 (IC50: 127 nM).Fórmula:C25H35BrFN5O2Cor e Forma:SolidPeso molecular:536.48IACS-8968 R-enantiomer
CAS:IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).Fórmula:C17H18F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.35IDO1/TDO-IN-2
CAS:IDO1/TDO-IN-2: IDO1/TDO inhibitor; IC50s: IDO1, 0.1μM; TDO, 0.07μM; potential for cancer research.Fórmula:C16H9N3O2Cor e Forma:SolidPeso molecular:275.26IDO/TDO-IN-1
CAS:IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).Fórmula:C25H24FN5Pureza:98%Cor e Forma:SolidPeso molecular:413.49IDO1-IN-15
CAS:IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.Fórmula:C13H14BrFN6O3Cor e Forma:SolidPeso molecular:401.19IDO-IN-16
CAS:IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).Fórmula:C22H21F3N4OCor e Forma:SolidPeso molecular:414.42IDO1-IN-17
CAS:IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Fórmula:C28H32BrClFN5O2Cor e Forma:SolidPeso molecular:604.94IDO-IN-14
CAS:IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).Fórmula:C23H23ClN4O2Cor e Forma:SolidPeso molecular:422.91MMG-0358
CAS:MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.Fórmula:C8H6ClN3OCor e Forma:SolidPeso molecular:195.61IDO1-IN-21
CAS:IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].Fórmula:C21H19F2N3O6SPureza:98%Cor e Forma:SolidPeso molecular:479.45IDO-IN-5
CAS:IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Fórmula:C18H21FN2O2Pureza:98%Cor e Forma:SolidPeso molecular:316.37Roxyl-9
CAS:Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].Fórmula:C18H13N3O2Cor e Forma:SolidPeso molecular:303.31TDO-IN-1
CAS:<p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>Fórmula:C16H13F3N4O2Pureza:99.86%Cor e Forma:SolidPeso molecular:350.3IDO1/2-IN-1
CAS:First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).Fórmula:C16H18BrFN8O4Cor e Forma:SolidPeso molecular:485.27(R)-IDO/TDO-IN-1
CAS:(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].Fórmula:C25H24FN5Cor e Forma:SolidPeso molecular:413.49NUCC-0223619
CAS:NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.Fórmula:C24H24ClFN2O2Cor e Forma:SolidPeso molecular:426.91IDO1/2-IN-1 hydrochloride
CAS:IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.Fórmula:C16H19BrClFN8O4Cor e Forma:SolidPeso molecular:521.73IDO1/TDO-IN-6
CAS:IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.Fórmula:C20H17NO5Pureza:98%Cor e Forma:SolidPeso molecular:351.35IDO-IN-9
CAS:IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).Fórmula:C13H13BrFN7O3SPureza:98%Cor e Forma:SolidPeso molecular:446.251-Isopropyltryptophan
CAS:1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].Fórmula:C14H18N2O2Pureza:98%Cor e Forma:SolidPeso molecular:246.3IDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Fórmula:C29H34FN3O2Cor e Forma:SolidPeso molecular:475.598IDO2-IN-1
CAS:IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.Fórmula:C21H21BrN10O3Cor e Forma:SolidPeso molecular:541.36VS-15
CAS:VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Fórmula:C29H27N5O3Cor e Forma:SolidPeso molecular:493.56IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Fórmula:C20H16BrN5O2SCor e Forma:SolidPeso molecular:470.34IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Fórmula:C14H8Cl3NO2SCor e Forma:SolidPeso molecular:360.64IDO1-IN-14
IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.Fórmula:C18H12Cl2FN3O2Cor e Forma:SolidPeso molecular:392.21IDO antagonist-1
CAS:IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].Fórmula:C39H53N7O5Cor e Forma:SolidPeso molecular:699.884-Phenyl-1H-1,2,3-triazole
CAS:4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].Fórmula:C8H7N3Pureza:98%Cor e Forma:SolidPeso molecular:145.16
