ROR
Os receptores órfãos relacionados ao ácido retinoico (RORs) são receptores nucleares que regulam vários processos fisiológicos, incluindo ritmo circadiano, resposta imune e metabolismo. Inibidores de RORs são de grande interesse no estudo de doenças autoimunes, distúrbios metabólicos e câncer, pois podem modular a expressão gênica e influenciar as funções celulares. Na CymitQuimica, oferecemos inibidores de RORs para apoiar sua pesquisa em imunologia, endocrinologia e oncologia.
Foram encontrados 42 produtos de "ROR"
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SR0987
CAS:<p>SR0987 is a RORγt agonist,</p>Fórmula:C16H10ClF6NO2Pureza:99.43%Cor e Forma:SolidPeso molecular:397.7Nobiletin
CAS:<p>Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.</p>Fórmula:C21H22O8Pureza:98.65% - 99.76%Cor e Forma:SolidPeso molecular:402.39MRL-871
CAS:<p>MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.</p>Fórmula:C22H12ClF3N2O3Pureza:99.66%Cor e Forma:SolidPeso molecular:444.79RORγt Inverse agonist 8
CAS:<p>RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).</p>Fórmula:C26H33N7O2Pureza:98%Cor e Forma:SolidPeso molecular:475.59Methyl-3β-hydroxycholenate
CAS:<p>Methyl-3β-hydroxycholenate (Methyl 3beta-hydroxychol-5-enoate) is a modulator of RORγ.</p>Fórmula:C25H40O3Pureza:98.78%Cor e Forma:SolidPeso molecular:388.58TF-S14
CAS:<p>TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.</p>Fórmula:C22H27N3O2SCor e Forma:SolidPeso molecular:397.53XY101
CAS:<p>XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).</p>Fórmula:C25H20F7NO4SPureza:99.83%Cor e Forma:SolidPeso molecular:563.48AZD-0284
CAS:<p>AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].</p>Fórmula:C21H18F6N2O5SPureza:99.82%Cor e Forma:SolidPeso molecular:524.43ML 209
CAS:<p>ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription</p>Fórmula:C25H31NO6Pureza:99.87%Cor e Forma:SolidPeso molecular:441.52SR2211
CAS:<p>SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).</p>Fórmula:C26H24F7N3OPureza:98.75%Cor e Forma:SolidPeso molecular:527.483-Oxo-5β-cholanoic acid
CAS:<p>3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly</p>Fórmula:C24H38O3Pureza:98.01% - 99.86%Cor e Forma:SolidPeso molecular:374.56RORγt Inverse agonist 6
CAS:<p>RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.</p>Fórmula:C28H29ClN6O5Pureza:99.52%Cor e Forma:SolidPeso molecular:565.02FM26
CAS:<p>FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.</p>Fórmula:C22H15ClF3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:461.82TMP780
CAS:<p>TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.</p>Fórmula:C31H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:494.58RORγt inverse agonist 14
CAS:<p>RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.</p>Fórmula:C26H26F8N2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:678.61RORγt inverse agonist 34
CAS:<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Fórmula:C31H37N3O3SCor e Forma:SolidPeso molecular:531.709RORγt inhibitor 4
CAS:<p>RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.</p>Fórmula:C22H16Cl2F3NO4SCor e Forma:SolidPeso molecular:518.333ROR1-IN-1
CAS:<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Fórmula:C33H27N5O3Peso molecular:541.60TAK-828F
CAS:<p>TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.</p>Fórmula:C28H32FN3O5Pureza:98%Cor e Forma:SolidPeso molecular:509.57RORγt inverse agonist 32
CAS:<p>RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.</p>Fórmula:C24H28F3NO5SCor e Forma:SolidPeso molecular:499.54
