ROR
Os receptores órfãos relacionados ao ácido retinoico (RORs) são receptores nucleares que regulam vários processos fisiológicos, incluindo ritmo circadiano, resposta imune e metabolismo. Inibidores de RORs são de grande interesse no estudo de doenças autoimunes, distúrbios metabólicos e câncer, pois podem modular a expressão gênica e influenciar as funções celulares. Na CymitQuimica, oferecemos inibidores de RORs para apoiar sua pesquisa em imunologia, endocrinologia e oncologia.
Foram encontrados 47 produtos de "ROR"
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RORγt inverse agonist 34
CAS:RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.Fórmula:C31H37N3O3SCor e Forma:SolidPeso molecular:531.709RORγ-IN-2
CAS:RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.
Fórmula:C28H32F3N5O4S2Cor e Forma:SolidPeso molecular:623.71RORγt inverse agonist 32
CAS:RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Fórmula:C24H28F3NO5SCor e Forma:SolidPeso molecular:499.54TAK-828F
CAS:TAK-828F: potent, selective RORγt inverse agonist. Oral. IC50=1.9 nM; reporter gene IC50=6.1 nM.Fórmula:C28H32FN3O5Pureza:98%Cor e Forma:SolidPeso molecular:509.57RORγt inhibitor 4
CAS:RORγt inhibitor 4 (Compound 9a) is an orally active RORγt inhibitor capable of penetrating the central nervous system. It has been shown to improve experimental autoimmune encephalomyelitis.Fórmula:C22H16Cl2F3NO4SCor e Forma:SolidPeso molecular:518.333ROR1-IN-1
CAS:ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.Fórmula:C33H27N5O3Peso molecular:541.60Vimirogant
CAS:Vimirogant is a RORγ inhibitor (Ki: <100 nM).Fórmula:C27H35F3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:552.65
