NAMPT
A nicotinamida fosforribosiltransferase (NAMPT) é uma enzima envolvida na biossíntese de nicotinamida adenina dinucleotídeo (NAD+), uma coenzima crítica no metabolismo celular e na produção de energia. Os inibidores de NAMPT são de grande interesse na pesquisa do câncer devido à sua capacidade de interromper o metabolismo do NAD+ e induzir a morte celular em células cancerígenas. Esses inibidores também são explorados no contexto de distúrbios metabólicos e envelhecimento. Na CymitQuimica, oferecemos inibidores de NAMPT para apoiar sua pesquisa em biologia do câncer, metabolismo e envelhecimento.
Foram encontrados 40 produtos para "NAMPT".
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SBI-797812
CAS:SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).Fórmula:C19H22N4O4SPureza:99.31%Cor e Forma:White SolidPeso molecular:402.467Nampt-IN-5
CAS:Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .Fórmula:C25H25N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:427.4983Nampt activator-1
CAS:NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.Fórmula:C16H17N3O3Pureza:99.84% - 99.98%Cor e Forma:SolidPeso molecular:299.3245ALT-100 (Human IgG1)
ALT-100 (Human IgG1) is a neutralizing mAb targeting eNAMPT used to study the treatment mechanisms of myocardial fibrosis and inflammatory diseases by blocking DAMP signaling.Pureza:95%Cor e Forma:Odour LiquidPeso molecular:144.9 kDa (Predicted)CB 300919
CAS:CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.Fórmula:C32H34ClN7O2Cor e Forma:SolidPeso molecular:584.111Nampt-IN-10 trihydrochloride
Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.Fórmula:C27H31Cl3FN5O2Cor e Forma:SolidPeso molecular:582.92Nampt degrader-2
Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.Fórmula:C59H73N9O7SCor e Forma:SolidPeso molecular:1052.33NAMPT degrader-3
NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.Fórmula:C56H74N8O7SPureza:98%Cor e Forma:SolidPeso molecular:1003.3PROTAC NAMPT Degrader-1
PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.Fórmula:C57H69N13O8S2Cor e Forma:SolidPeso molecular:1127.48335LYP-8
LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.Fórmula:C56H74N8O10SCor e Forma:SolidPeso molecular:1050.52486NAMPT activator-7
NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.Fórmula:C21H17ClN4O3Cor e Forma:SolidPeso molecular:408.09892Nampt-IN-13 FA
Nampt-IN-13 FA is a NAMPT inhibitor (patent WO2021013693A1) suitable for synthesising antibody-drug conjugates (ADCs).Fórmula:C25H32N6O4Pureza:99.06% - 99.30%Cor e Forma:Yellow SolidPeso molecular:480.56PROTAC NAMPT Degrader-28
PROTAC NAMPT Degrader-28 is a NAMPT PROTAC degrader with DC50 values of 45 nM and 55 nM in MCF7 and 4T1cl5 cells, respectively. It retains nicotinamide phosphoribosyltransferase inhibitory activity without inducing enzyme degradation. PROTAC NAMPT Degrader-28 is applicable for breast cancer-related research.NAMPT Protein, Human, Recombinant (His)
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, butPureza:94% - 94%Cor e Forma:Lyophilized PowderPeso molecular:55 KDa (reducing condition)NAT
CAS:NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.Fórmula:C18H21NO3Pureza:99.65%Cor e Forma:White SolidPeso molecular:299.3642(E)-Daporinad
CAS:(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.Fórmula:C24H29N3O2Pureza:98.44% - >99.99%Cor e Forma:White SolidPeso molecular:391.51Nampt-IN-1
CAS:Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Fórmula:C20H25N3O5SPureza:99.28% - 99.4%Cor e Forma:SolidPeso molecular:419.495KPT9274
CAS:KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.Fórmula:C35H29F3N4O3Pureza:99.01% - 99.93%Cor e Forma:SolidPeso molecular:610.625LB-60-OF61 hydrochloride
CAS:LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.Fórmula:C29H31ClN6O2Cor e Forma:SolidPeso molecular:531.06CHS-828
CAS:CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).Fórmula:C19H22ClN5OPureza:98% - 99.9%Cor e Forma:White SolidPeso molecular:371.864
