PPAR
Os receptores ativados por proliferadores de peroxissomas (PPARs) são um grupo de proteínas receptoras nucleares que funcionam como fatores de transcrição, regulando a expressão de genes envolvidos no metabolismo, particularmente no armazenamento de ácidos graxos e no metabolismo da glicose. Inibidores de PPAR são ferramentas importantes para o estudo de distúrbios metabólicos como diabetes, obesidade e doenças cardiovasculares. Esses inibidores podem modular o metabolismo lipídico, a sensibilidade à insulina e a inflamação, tornando-os valiosos na pesquisa terapêutica. Na CymitQuimica, oferecemos uma gama de inibidores de PPAR para apoiar sua pesquisa em doenças metabólicas, endocrinologia e desenvolvimento de medicamentos.
Foram encontrados 164 produtos de "PPAR"
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T0070907
CAS:<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Fórmula:C12H8ClN3O3Pureza:98.25% - 99.98%Cor e Forma:SolidPeso molecular:277.66Angeloylgomisin H
CAS:<p>Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.</p>Fórmula:C28H36O8Pureza:99.84% - 99.95%Cor e Forma:SolidPeso molecular:500.58Oleuropein
CAS:<p>Oleuropein is an antioxidant polyphenol isolated from olive leaf.</p>Fórmula:C25H32O13Pureza:98% - 99.95%Cor e Forma:Brown PowderPeso molecular:540.51GSK0660
CAS:<p>GSK0660 is an antagonist and inverse agonist of PPARβ/δ.</p>Fórmula:C19H18N2O5S2Pureza:99.26% - ≥95%Cor e Forma:SolidPeso molecular:418.49Rosiglitazone hydrochloride
CAS:<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>Fórmula:C18H19N3O3S·HClPureza:99.63% - 99.79%Cor e Forma:SolidPeso molecular:393.89EPI-001
CAS:<p>EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.</p>Fórmula:C21H27ClO5Pureza:99% - 99.67%Cor e Forma:SolidPeso molecular:394.89Clofibrate
CAS:<p>Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.</p>Fórmula:C12H15ClO3Pureza:98.77%Cor e Forma:Oil LiquidPeso molecular:242.70DG172 dihydrochloride
CAS:<p>DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).</p>Fórmula:C20H22BrCl2N3Pureza:99.87%Cor e Forma:SolidPeso molecular:455.2L-165041
CAS:<p>L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)</p>Fórmula:C22H26O7Pureza:97.97%Cor e Forma:SolidPeso molecular:402.44GSK3787
CAS:<p>GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.</p>Fórmula:C15H12ClF3N2O3SPureza:98% - 99.56%Cor e Forma:SolidPeso molecular:392.78Oroxin A
CAS:<p>Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.</p>Fórmula:C21H20O10Pureza:98.05% - 99.74%Cor e Forma:SolidPeso molecular:432.38AMG131
CAS:<p>AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for</p>Fórmula:C21H12Cl4N2O3SPureza:99.37%Cor e Forma:SolidPeso molecular:514.21Gypenoside XLIX
CAS:<p>Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition</p>Fórmula:C52H86O21Pureza:97.05% - 99.78%Cor e Forma:SolidPeso molecular:1047.23Elafibranor
CAS:<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>Fórmula:C22H24O4SPureza:98.42% - 98.78%Cor e Forma:SolidPeso molecular:384.49Cinnamyl alcohol
CAS:<p>Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.</p>Fórmula:C9H10OPureza:99.00%Cor e Forma:Colourless LiquidPeso molecular:134.18Tesaglitazar
CAS:<p>Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα</p>Fórmula:C20H24O7SPureza:99.95%Cor e Forma:SolidPeso molecular:408.47Pparδ agonist 2
CAS:<p>Pparδ agonist 2 is an agonist of PPARδ.</p>Fórmula:C20H18F3N3O3SPureza:98%Cor e Forma:SolidPeso molecular:437.44FTX-6746
CAS:<p>FTX-6746 is an orally active and selective PPARG reverse inhibitor with anticancer activity. It can be used in research on urothelial carcinoma.</p>Fórmula:C16H7ClF2N2OPureza:98.68%Cor e Forma:SolidPeso molecular:316.6913-Oxo-9E,11E-octadecadienoic acid
CAS:<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Fórmula:C18H30O3Pureza:98%Cor e Forma:SolidPeso molecular:294.43Peliglitazar racemate
CAS:<p>Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity</p>Fórmula:C30H30N2O7Pureza:97.75%Cor e Forma:SolidPeso molecular:530.57Daltroban
CAS:<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Fórmula:C16H16ClNO4SPureza:99.74%Cor e Forma:SolidPeso molecular:353.82GW 9578
CAS:<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Fórmula:C26H34F2N2O3SPureza:98%Cor e Forma:SolidPeso molecular:492.62ARH-049020
CAS:<p>ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.</p>Fórmula:C24H31NO6Pureza:97.19% - 99.82%Cor e Forma:SolidPeso molecular:429.51Reglitazar
CAS:<p>Reglitazar, a dual PPARα/γ agonist, enhances insulin signaling, reduces insulin resistance, and lowers hypertriglyceridemia in obese rats.</p>Fórmula:C22H20N2O5Pureza:97.07% - 98.72%Cor e Forma:SolidPeso molecular:392.4THR-0921
CAS:<p>THR-0921 (CLX-0921) is a peroxisome proliferator-activated receptor (PPAR) agonist that can be used to study cardiovascular and metabolic diseases.</p>Fórmula:C28H25NO7SPureza:100% - 99.83%Cor e Forma:SolidPeso molecular:519.57AVE-8134
CAS:<p>AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.</p>Fórmula:C22H23NO5Pureza:98%Cor e Forma:SolidPeso molecular:381.42PPARα-MO-1
CAS:<p>PPARα-MO-1 is a potent modulator of PPARα.</p>Fórmula:C27H37NO5Pureza:98%Cor e Forma:SolidPeso molecular:455.59LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Fórmula:C26H36O3Cor e Forma:SolidPeso molecular:396.56Chiglitazar
CAS:<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Fórmula:C36H29FN2O4Cor e Forma:SolidPeso molecular:572.63Inolitazone dihydrochloride
CAS:<p>Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth.</p>Fórmula:C27H28Cl2N4O4SCor e Forma:SolidPeso molecular:575.51Saroglitazar
CAS:<p>Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.</p>Fórmula:C25H29NO4SPureza:98.51%Cor e Forma:SolidPeso molecular:439.57GSK376501A
CAS:<p>GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.</p>Fórmula:C32H37NO6Pureza:>99.99%Cor e Forma:SolidPeso molecular:531.64Indeglitazar
CAS:<p>Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).</p>Fórmula:C19H19NO6SPureza:99.45%Cor e Forma:SolidPeso molecular:389.42K-111
CAS:<p>K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.</p>Fórmula:C18H25Cl3O2Pureza:99.64% - 99.88%Cor e Forma:SolidPeso molecular:379.75Farglitazar
CAS:<p>Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer used in the study of diabetes.</p>Fórmula:C34H30N2O5Pureza:99.4% - 99.52%Cor e Forma:SolidPeso molecular:546.61Cevoglitazar
CAS:Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.Fórmula:C27H21F3N2O6SPureza:97%Cor e Forma:SolidPeso molecular:558.53Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Fórmula:C16H17N3O2Pureza:98.81%Cor e Forma:SolidPeso molecular:283.33BAY-0069
CAS:<p>BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be</p>Fórmula:C22H16BrN3O4Pureza:99.41%Cor e Forma:SoildPeso molecular:466.28Linotroban
CAS:<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Fórmula:C14H15NO5S2Pureza:97.95% - >99.99%Cor e Forma:SolidPeso molecular:341.4BAY-4931
CAS:<p>BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.</p>Fórmula:C22H16ClN3O4Pureza:99.47%Cor e Forma:SoildPeso molecular:421.83Edaglitazone
CAS:<p>Edaglitazone (R-483) is a PPARγ agonist with antiplatelet activity that can be used in studies of diabetes and obesity.</p>Fórmula:C24H20N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:464.56LCB-2853
CAS:<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Fórmula:C21H24ClNO4SPureza:97.15%Cor e Forma:SolidPeso molecular:421.94Imiglitazar
CAS:<p>Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.</p>Fórmula:C28H26N2O5Pureza:97.33%Cor e Forma:SolidPeso molecular:470.52PPAR agonist 1
CAS:<p>PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.</p>Fórmula:C20H25NO6SPureza:98%Cor e Forma:SolidPeso molecular:407.48U-46619
CAS:<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Fórmula:C21H34O4Pureza:98%Cor e Forma:SolidPeso molecular:350.49KD-3010
CAS:<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Fórmula:C30H33F3N2O8S2Pureza:99.61%Cor e Forma:SolidPeso molecular:670.72CRX000227
CAS:<p>CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].</p>Fórmula:C25H24N4O2SPureza:98%Cor e Forma:SolidPeso molecular:444.55PPARγ agonist 8
CAS:<p>PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator</p>Fórmula:C19H12F4O2SPureza:98%Cor e Forma:SolidPeso molecular:380.36Darglitazone
CAS:<p>Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.</p>Fórmula:C23H20N2O4SPureza:99.76%Cor e Forma:SolidPeso molecular:420.48PPARδ agonist 9
CAS:<p>PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic</p>Fórmula:C26H28ClF3N4O3SPureza:98%Cor e Forma:SolidPeso molecular:569.04Ragaglitazar
CAS:<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Fórmula:C25H25NO5Pureza:97.46% - 98.56%Cor e Forma:SolidPeso molecular:419.47Inolitazone
CAS:<p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>Fórmula:C27H26N4O4SPureza:99.41% - 99.53%Cor e Forma:SolidPeso molecular:502.58Fonadelpar
CAS:<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Fórmula:C25H23F3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:504.52Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Fórmula:C32H51N3O2Cor e Forma:SolidPeso molecular:509.766PPARγ agonist 17
CAS:<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Fórmula:C48H63NO7Cor e Forma:SolidPeso molecular:766.016PPARγ modulator-2
CAS:<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Fórmula:C26H21NO7S3SeCor e Forma:SolidPeso molecular:634.6Amezalpat
CAS:<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Fórmula:C34H41N3O4Cor e Forma:SolidPeso molecular:555.707PPARγ-IN-5
CAS:<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Fórmula:C22H23ClO7Cor e Forma:SolidPeso molecular:434.867PPARα/δ agonist 3
CAS:<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Fórmula:C23H25F3N2O4Cor e Forma:SolidPeso molecular:450.451PPARδ agonist 11
CAS:<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Fórmula:C19H15F3N2O3S2Cor e Forma:SolidPeso molecular:440.46Aleglitazar
CAS:<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Fórmula:C24H23NO5SPureza:99.03%Cor e Forma:SolidPeso molecular:437.51Anti-NASH agent 1
CAS:<p>Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).</p>Fórmula:C26H33NO4Pureza:98%Cor e Forma:SolidPeso molecular:423.54Ref: TM-T79454
Produto descontinuadoPPARγ-IN-2
CAS:<p>"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.</p>Fórmula:C19H21N5OPureza:98%Cor e Forma:SolidPeso molecular:335.4Ref: TM-T79678
Produto descontinuadoMavodelpar free base
CAS:<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Fórmula:C31H30FNO5Pureza:98%Cor e Forma:SolidPeso molecular:515.57
