PPAR
Os receptores ativados por proliferadores de peroxissomas (PPARs) são um grupo de proteínas receptoras nucleares que funcionam como fatores de transcrição, regulando a expressão de genes envolvidos no metabolismo, particularmente no armazenamento de ácidos graxos e no metabolismo da glicose. Inibidores de PPAR são ferramentas importantes para o estudo de distúrbios metabólicos como diabetes, obesidade e doenças cardiovasculares. Esses inibidores podem modular o metabolismo lipídico, a sensibilidade à insulina e a inflamação, tornando-os valiosos na pesquisa terapêutica. Na CymitQuimica, oferecemos uma gama de inibidores de PPAR para apoiar sua pesquisa em doenças metabólicas, endocrinologia e desenvolvimento de medicamentos.
Foram encontrados 164 produtos de "PPAR"
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Retinoic acid
CAS:<p>Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.</p>Fórmula:C20H28O2Pureza:97.21% - 99.6%Cor e Forma:Yellow-Orange PowderPeso molecular:300.44Clofibric acid
CAS:<p>Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.</p>Fórmula:C10H11ClO3Pureza:99.47% - 99.8%Cor e Forma:Pale Yellow SolidPeso molecular:214.65MA-0204
CAS:<p>MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human,</p>Fórmula:C25H27F3N2O4Pureza:97.8%Cor e Forma:SolidPeso molecular:476.49Oleoylethanolamide
CAS:<p>Oleoylethanolamide (N-Oleoylethanolamide) is a high affinity endogenous agonist of PPAR-α.</p>Fórmula:C20H39NO2Pureza:99.98%Cor e Forma:SolidPeso molecular:325.53Fenofibric acid
CAS:<p>Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.</p>Fórmula:C17H15ClO4Pureza:99.36%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:318.75MK-0533
CAS:<p>MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.</p>Fórmula:C28H24F3NO6Pureza:99.03%Cor e Forma:SoildPeso molecular:527.49Arhalofenate
CAS:<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>Fórmula:C19H17ClF3NO4Pureza:98.97%Cor e Forma:SolidPeso molecular:415.79Pioglitazone
CAS:<p>Pioglitazone (U 72107) is a selective and oral PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively . High-Quality, Low-Cost!</p>Fórmula:C19H20N2O3SPureza:95% - 99.57%Cor e Forma:White PowderPeso molecular:356.44Sulotroban potassium
<p>Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.</p>Fórmula:C16H16KNO5SPureza:98.02%Cor e Forma:SoildPeso molecular:373.46MCC-555
CAS:<p>MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.</p>Fórmula:C21H16FNO3SPureza:99.07% - 99.82%Cor e Forma:SolidPeso molecular:381.42Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
CAS:<p>Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM.</p>Fórmula:C24H23NO5SPureza:99.59%Cor e Forma:SoildPeso molecular:437.51Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour SolidWAY-620472
CAS:<p>WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.</p>Fórmula:C23H21N5OSPureza:98.07%Cor e Forma:SolidPeso molecular:415.51PPARγ-IN-3
<p>PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.</p>Fórmula:C23H28FN7O3Cor e Forma:SolidPeso molecular:469.51Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Fórmula:C21H22N2O6Cor e Forma:SolidPeso molecular:398.409CUDA
CAS:<p>CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.</p>Fórmula:C19H36N2O3Pureza:97.585%Cor e Forma:SolidPeso molecular:340.58-iso Prostaglandin F1α
CAS:<p>8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.</p>Fórmula:C20H36O5Cor e Forma:SolidPeso molecular:356.5CC618
CAS:<p>CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.</p>Fórmula:C20H15F6N3O3S2Pureza:99.94%Cor e Forma:SolidPeso molecular:523.47PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Cor e Forma:Odour SolidSulotroban
CAS:<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Fórmula:C16H17NO5SPureza:98.86% - 99.88%Cor e Forma:SolidPeso molecular:335.37
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