PPAR
Os receptores ativados por proliferadores de peroxissomas (PPARs) são um grupo de proteínas receptoras nucleares que funcionam como fatores de transcrição, regulando a expressão de genes envolvidos no metabolismo, particularmente no armazenamento de ácidos graxos e no metabolismo da glicose. Inibidores de PPAR são ferramentas importantes para o estudo de distúrbios metabólicos como diabetes, obesidade e doenças cardiovasculares. Esses inibidores podem modular o metabolismo lipídico, a sensibilidade à insulina e a inflamação, tornando-os valiosos na pesquisa terapêutica. Na CymitQuimica, oferecemos uma gama de inibidores de PPAR para apoiar sua pesquisa em doenças metabólicas, endocrinologia e desenvolvimento de medicamentos.
Foram encontrados 170 produtos de "PPAR"
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MCC-555
CAS:MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.Fórmula:C21H16FNO3SPureza:99.07% - 99.82%Cor e Forma:SolidPeso molecular:381.42Ref: TM-T21764
5mg66,00€10mg105,00€25mg215,00€50mg356,00€100mg530,00€500mg1.153,00€1mL*10mM (DMSO)73,00€PPAR agonist 6
PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].Cor e Forma:Odour SolidPPARγ-IN-3
PPARγ-IN-3 (compound 9ga), a potent and orally active PPARγ inhibitor, effectively reduces triglyceride (TG) accumulation and exhibits low cytotoxicity. Additionally, it prevents excessive body weight gain, lessens fat and liver mass, and decreases lipid accumulation in both the liver and blood. PPARγ-IN-3 holds promise for research into diet-induced obesity.Fórmula:C23H28FN7O3Cor e Forma:SolidPeso molecular:469.51Anti-obesity agent 1
Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.
Fórmula:C21H22N2O6Cor e Forma:SolidPeso molecular:398.409CUDA
CAS:CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.
Fórmula:C19H36N2O3Pureza:97.585%Cor e Forma:SolidPeso molecular:340.58-iso Prostaglandin F1β
CAS:8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.Fórmula:C20H36O5Cor e Forma:SolidPeso molecular:356.5Sulotroban
CAS:sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.Fórmula:C16H17NO5SPureza:98.86% - 99.98%Cor e Forma:SolidPeso molecular:335.37CC618
CAS:CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Fórmula:C20H15F6N3O3S2Pureza:99.94%Cor e Forma:SolidPeso molecular:523.47Ref: TM-T9767
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)314,00€Anti-osteoporosis agent-10
Anti-osteoporosis agent-10 is an inhibitor of osteoporosis that suppresses the formation of osteoclasts with an IC50 of 0.042 μM. It also exhibits antagonistic activity towards PPARγ, with an EC50 value of 0.75 μM.Cor e Forma:Odour SolidLipid Metabolism Compound Library
A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).
Cor e Forma:Odour SolidAZD-9574
CAS:AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs.Fórmula:C21H22F2N6O2Pureza:98.46% - 99.39%Cor e Forma:SolidPeso molecular:428.44WAY-620472
CAS:WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.Fórmula:C23H21N5OSPureza:98.99%Cor e Forma:SolidPeso molecular:415.51PPAR α/PPARA Protein, Mouse, Recombinant (His)
PPAR alpha/PPARA Protein, Mouse, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:31.49 kDa (predicted)Ref: TM-TMPY-06837
5µg109,00€10µg174,00€20µg289,00€50µg576,00€100µg1.017,00€200µg1.718,00€500µg4.207,00€PPAR α/PPARA Protein, Human, Recombinant (His)
PPAR alpha/PPARA Protein, Human, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:31.36 kDa (predicted)Ref: TM-TMPY-06830
5µg116,00€10µg187,00€20µg305,00€50µg608,00€100µg1.063,00€200µg1.794,00€500µg3.832,00€Balaglitazone
CAS:Balaglitazone is a PPARγ agonist that regulates blood glucose and is used in studies of heart failure and myocardial infarction.Fórmula:C20H17N3O4SPureza:99.74%Cor e Forma:SolidPeso molecular:395.43CP-868388 free base
CAS:CP-868388 free base (CP-868388) is a PPARα agonist with hypolipidemic and anti-inflammatory activity and is used in the study of dyslipidemia.Fórmula:C26H33NO5Pureza:99.84%Cor e Forma:SolidPeso molecular:439.54GW0742
CAS:GW0742 (GW610742) is an effective and specific PPARδ agonist (EC50: 1 nM/1.1 μM/2 μM, for human PPARδ/α/γ).Fórmula:C21H17F4NO3S2Pureza:99.75% - 99.85%Cor e Forma:SolidPeso molecular:471.49Choline Fenofibrate
CAS:Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic
Fórmula:C22H28ClNO5Pureza:98.82%Cor e Forma:SolidPeso molecular:421.91MK-886
CAS:MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).Fórmula:C27H34ClNO2SPureza:99.23% - 99.84%Cor e Forma:SolidPeso molecular:472.08Ref: TM-T6893
1mg35,00€5mg70,00€10mg111,00€25mg216,00€50mg354,00€100mg540,00€200mg772,00€1mL*10mM (DMSO)72,00€SR 16832
CAS:SR 16832: Dual-site PPARγ inhibitor; outperforms GW 9662, T 0070907 in ligand binding, transcription inhibition.Fórmula:C17H12ClN3O4Pureza:99.6%Cor e Forma:SolidPeso molecular:357.75
