PPAR
Os receptores ativados por proliferadores de peroxissomas (PPARs) são um grupo de proteínas receptoras nucleares que funcionam como fatores de transcrição, regulando a expressão de genes envolvidos no metabolismo, particularmente no armazenamento de ácidos graxos e no metabolismo da glicose. Inibidores de PPAR são ferramentas importantes para o estudo de distúrbios metabólicos como diabetes, obesidade e doenças cardiovasculares. Esses inibidores podem modular o metabolismo lipídico, a sensibilidade à insulina e a inflamação, tornando-os valiosos na pesquisa terapêutica. Na CymitQuimica, oferecemos uma gama de inibidores de PPAR para apoiar sua pesquisa em doenças metabólicas, endocrinologia e desenvolvimento de medicamentos.
Foram encontrados 170 produtos de "PPAR"
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Amezalpat
CAS:Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.Fórmula:C34H41N3O4Cor e Forma:SolidPeso molecular:555.707PPARγ-IN-5
CAS:PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.
Fórmula:C22H23ClO7Cor e Forma:SolidPeso molecular:434.867PPARα/δ agonist 3
CAS:PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.Fórmula:C23H25F3N2O4Cor e Forma:SolidPeso molecular:450.451PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Fórmula:C19H15F3N2O3S2Cor e Forma:SolidPeso molecular:440.46Fonadelpar
CAS:Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.Fórmula:C25H23F3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:504.52PPARγ agonist 10
CAS:PPARγ agonist 10 (compound 33g) serves as a PPARγ agonist, enhancing insulin secretion, glucose uptake, and insulin sensitivity in βTC6 cells [1].Fórmula:C17H14N4O3S2Cor e Forma:SolidPeso molecular:386.45Aleglitazar
CAS:Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.Fórmula:C24H23NO5SPureza:99.03%Cor e Forma:SolidPeso molecular:437.51Ref: TM-T14176
1mg245,00€5mg562,00€10mg758,00€25mg1.159,00€50mg1.568,00€100mg2.110,00€1mL*10mM (DMSO)568,00€PPARγ-IN-2
CAS:"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.
Fórmula:C19H21N5OPureza:98%Cor e Forma:SolidPeso molecular:335.4Ref: TM-T79678
Produto descontinuadoMavodelpar free base
CAS:Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.
Fórmula:C31H30FNO5Pureza:98%Cor e Forma:SolidPeso molecular:515.57Anti-NASH agent 1
CAS:Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).
Fórmula:C26H33NO4Pureza:98%Cor e Forma:SolidPeso molecular:423.54Ref: TM-T79454
Produto descontinuado
