FXR
O Receptor Farnesoide X (FXR) é um receptor nuclear que desempenha um papel crucial na regulação da homeostase dos ácidos biliares, do metabolismo dos lipídios e da regulação da glicose. O FXR é um alvo terapêutico potencial para o tratamento de doenças hepáticas, distúrbios metabólicos e doenças cardiovasculares. Os inibidores de FXR podem modular essas vias, oferecendo insights sobre os mecanismos de doenças e estratégias terapêuticas. Na CymitQuimica, oferecemos uma variedade de inibidores de FXR para apoiar sua pesquisa em hepatologia, metabolismo e desenvolvimento de medicamentos.
Foram encontrados 62 produtos de "FXR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.74% - ≥95%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Fórmula:C28H27Cl2N3O4Pureza:99.16% - 99.78%Cor e Forma:SolidPeso molecular:540.44Ref: TM-T15806
1mg99,00€5mg215,00€10mg349,00€25mg700,00€50mg1.108,00€100mg1.485,00€200mg2.008,00€1mL*10mM (DMSO)255,00€Chenodeoxycholic acid
CAS:Chenodeoxycholic acid (CDCA) is a bile acid that inhibits 11β-HSD2 with an IC50 value of 22 mM. High-Quality, Low-Cost!
Fórmula:C24H40O4Pureza:99.70% - 99.93%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57FXR agonist 11
CAS:FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.Fórmula:C18H16N2O5Cor e Forma:SolidPeso molecular:340.33Alismanol M
CAS:Alismanol M: FXR agonist, EC50 of 50.25 μM, from Alisma orientale, for cholestasis & NASH research.Fórmula:C30H48O6Cor e Forma:SolidPeso molecular:504.7ZLY28
ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1.Fórmula:C29H23Cl2NO4Pureza:98%Cor e Forma:SolidPeso molecular:520.4LH10
LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).Fórmula:C34H33N3O2Cor e Forma:SolidPeso molecular:515.64LZ-007
CAS:LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.Fórmula:C27H29F3N2O5Cor e Forma:SolidPeso molecular:518.53Fexarene
CAS:Fexarene is a non-steroidal FXR agonist.Fórmula:C32H33NO3Pureza:98%Cor e Forma:SolidPeso molecular:479.62FXR agonist 10
FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.Fórmula:C15H22O4Cor e Forma:SolidPeso molecular:266.33Nuclear Receptor Compound Library
A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;
Cor e Forma:Odour SolidFXR agonist 5
CAS:FXR agonist 5 is an FXR agonist used in the study of liver diseases or diseases mediated by metabolic inflammation.Fórmula:C40H53N5O5Pureza:99.74%Cor e Forma:SolidPeso molecular:683.88FXR antagonist 2
CAS:Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.Fórmula:C22H26Cl2N2O2Cor e Forma:SolidPeso molecular:421.36Tauro-β-muricholic acid sodium
CAS:Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).Fórmula:C26H44NNaO7SPureza:98%Cor e Forma:SolidPeso molecular:537.69FXR/TGR5 agonist 1
CAS:FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.Fórmula:C31H32ClN3O3Cor e Forma:SolidPeso molecular:530.07F44-A13
CAS:F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].Fórmula:C28H40N4O5SPeso molecular:544.71NR1H4 Protein, Mouse, Recombinant (His)
NR1H4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27.80 kDa.Cor e Forma:Lyophilized PowderPeso molecular:27.80 kDa (predicted)Ref: TM-TMPY-06756
5µg109,00€10µg174,00€20µg289,00€50µg576,00€100µg1.017,00€200µg1.718,00€500µg4.207,00€NDB
CAS:NDB is a hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions in primary mouse hepatocytes.NDB is used in the study of diabetes.Fórmula:C26H28Cl2N2O2Pureza:98.94%Cor e Forma:SolidPeso molecular:471.42FXR agonist 3
FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.Fórmula:C28H28BrNO4Pureza:95.04%Cor e Forma:SolidPeso molecular:521.12NR1H4 Protein, Human, Recombinant (His)
NR1H4 Protein, Human, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:27.83 kDa (predicted)Ref: TM-TMPY-06768
5µg110,00€10µg177,00€20µg289,00€50µg576,00€100µg1.007,00€200µg1.700,00€500µg3.631,00€
