Desidrogenase
As desidrogenases são enzimas envolvidas nas reações de oxidação-redução das vias metabólicas, desempenhando um papel central na produção de energia e na respiração celular. Estas enzimas são cruciais para processos como o ciclo do ácido cítrico, a glicólise e a oxidação dos ácidos graxos. Os inibidores de desidrogenases são ferramentas importantes no estudo de doenças metabólicas, câncer e estresse oxidativo. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de desidrogenases para apoiar sua pesquisa em metabolismo, biologia do câncer e bioquímica.
Foram encontrados 302 produtos de "Desidrogenase"
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CAY10566
CAS:CAY10566 is a potent SCD1 inhibitor, orally bioavailable, with IC50s: HepG2 cells, 7.9nM; mouse, 4.5nM; human, 26nM.Fórmula:C18H17ClFN5O2Pureza:99.5% - 99.54%Cor e Forma:SolidPeso molecular:389.81Ref: TM-T14878
1mg48,00€5mg131,00€10mg195,00€25mg353,00€50mg505,00€100mg710,00€200mg954,00€1mL*10mM (DMSO)112,00€DHODH-IN-11
CAS:DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.Fórmula:C15H11N3O2Pureza:98.14%Cor e Forma:SolidPeso molecular:265.27BAY-2402234
CAS:BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.Fórmula:C21H18ClF5N4O4Pureza:98.9%Cor e Forma:SolidPeso molecular:520.84Ref: TM-T14501
1mg170,00€2mg234,00€5mg349,00€10mg537,00€25mg858,00€50mg1.161,00€100mg1.558,00€1mL*10mM (DMSO)401,00€IGUANA-1 free base
CAS:IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.Fórmula:C26H24ClN3O2Cor e Forma:SolidPeso molecular:445.94WAY-311610
CAS:WAY-311610 is an HSD11B1 inhibitor targeting 11β-HSD1 enzyme with 0.34 μM IC; used for neuropathic and inflammatory pain research.Fórmula:C16H13F3N4O2Pureza:99.75%Cor e Forma:SolidPeso molecular:350.3PDK-IN-1
CAS:PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.Fórmula:C20H16BrN7OCor e Forma:SolidPeso molecular:450.29MTHFD2-IN-4
MTHFD2-IN-4, a tricyclic coumarin derivative, serves as a potent inhibitor of MTHFD2 and has applications in cancer research [1].Fórmula:C26H21F6N2O5Cor e Forma:SolidPeso molecular:555.45MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Fórmula:C22H18N4O5Cor e Forma:SolidPeso molecular:418.4LDHA-IN-3
CAS:LDHA-IN-3 is a potent selenobenzene-based LDHA inhibitor with a 145.2 nM IC50, useful in cancer research.Fórmula:C13H9F3SePureza:99.71%Cor e Forma:SolidPeso molecular:301.17Ref: TM-T39805
1mg52,00€5mg113,00€10mg177,00€25mg371,00€50mg517,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)124,00€hDHODH-IN-13
CAS:hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications inCor e Forma:SoildCM121
CAS:CM121, a reversible ALDH1A2 inhibitor, targets active site with IC50=0.54μM, Kd=1.1μM, using hydrophobic interactions.Fórmula:C24H17FN4O3SCor e Forma:SolidPeso molecular:460.48DHODH-IN-18
CAS:DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).Fórmula:C21H16ClF5N6O4Cor e Forma:SolidPeso molecular:546.84D-Lactate dehydrogenase
CAS:D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.Cor e Forma:SolidMTHFD2-IN-1
MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Fórmula:C24H21NO6Cor e Forma:SolidPeso molecular:419.43Necroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Fórmula:C12H17NOSPureza:99.85%Cor e Forma:SoildPeso molecular:223.33PDK-IN-2
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.Fórmula:C17H23AsCl2N2O2S2Cor e Forma:SolidPeso molecular:497.3311β-HSD1-IN-11
CAS:11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13Fórmula:C15H11F3O3SPureza:99.61%Cor e Forma:SoildPeso molecular:328.31Ref: TM-T60149
1mg109,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mg2.043,00€1mL*10mM (DMSO)239,00€Ascochlorin A
CAS:Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFórmula:C23H31ClO4Cor e Forma:SolidPeso molecular:406.95hDHODH-IN-12
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM.Fórmula:C22H15F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:440.372,3-Dihydroxybenzaldehyde
CAS:2,3-Dihydroxybenzaldehyde exhibits activity against NADH dehydrogenase (Km = 35 µM) and can be used in biochemical experiments and drug synthesis.Fórmula:C7H6O3Cor e Forma:SolidPeso molecular:138.12
