AhR
O Receptor de Hidrocarbonetos Aromáticos (AhR) é um fator de transcrição ativado por ligantes que desempenha um papel crítico na regulação das respostas biológicas a contaminantes ambientais, como dioxinas. O AhR também está envolvido no metabolismo de xenobióticos e na regulação das respostas imunológicas, proliferação e diferenciação celular. A desregulação da sinalização do AhR está associada a várias doenças, incluindo câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma gama de inibidores de AhR para apoiar sua pesquisa em toxicologia, biologia do câncer e imunologia.
Foram encontrados 41 produtos de "AhR"
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Leflunomide
CAS:<p>Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.</p>Fórmula:C12H9F3N2O2Pureza:99.52% - 99.96%Cor e Forma:Off White Crystalline SolidPeso molecular:270.21Mexiletine hydrochloride
CAS:<p>Mexiletine hydrochloride is a lidocaine-like antiarrhythmic (Class IB) and anesthetic, stabilizing heartbeats by inhibiting sodium in cardiac cells.</p>Fórmula:C11H18ClNOPureza:99.88%Cor e Forma:White To Off-White SolidPeso molecular:215.72BAY 2416964
CAS:<p>BAY 2416964 is a small molecule inhibitor that selectively targets aromatic receptor (AhR) and is commonly used in tumor research. Cost-effective and quality-assured.</p>Fórmula:C18H18ClN5O3Pureza:99.15% - 99.85%Cor e Forma:SolidPeso molecular:387.82GNF351
CAS:<p>GNF351: Full AHR antagonist, inhibits DRE-dependent/independent activity, low toxicity, binds AHR (IC50: 62 nM).</p>Fórmula:C24H25N7Pureza:98.43%Cor e Forma:SolidPeso molecular:411.5Diosmin
CAS:<p>Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.</p>Fórmula:C28H32O15Pureza:97.90%Cor e Forma:Greyish-Yellow Or Light Yellow Hygroscopic PowderPeso molecular:608.54MeBIO
CAS:<p>MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.</p>Fórmula:C17H12BrN3O2Pureza:99.64%Cor e Forma:SolidPeso molecular:370.2WAY-605471
CAS:<p>WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.</p>Fórmula:C14H15NO3S2Pureza:99.62%Cor e Forma:SolidPeso molecular:309.4KYN-101
CAS:<p>KYN-101 is an and aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity. KYN-101 is used for the study of breast cancer and acute myeloid leukemia.</p>Fórmula:C22H19FN6Pureza:98.35%Cor e Forma:SolidPeso molecular:386.43AHR Inhibitor I-103
CAS:<p>AHR Inhibitor I-103 is an aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity used in the study of breast cancer and acute myeloid leukemia.</p>Fórmula:C21H17FN6Pureza:98.70%Cor e Forma:SoildPeso molecular:372.43',4'-Dimethoxyflavone
CAS:<p>3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.</p>Fórmula:C17H14O4Pureza:98.05%Cor e Forma:SolidPeso molecular:282.29StemRegenin 1 Hydrochloride
CAS:<p>StemRegenin 1 Hydrochloride is an AhR antagonist (IC₅₀ = 127 nM) that inhibits RANKL-induced osteoclast generation and differentiation.</p>Fórmula:C24H24ClN5OSPureza:99.94%Cor e Forma:SolidPeso molecular:466Carbidopa monohydrate
CAS:<p>Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.</p>Fórmula:C10H16N2O5Pureza:98.11% - 98.30%Cor e Forma:SolidPeso molecular:244.24PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Cor e Forma:Yellow SolidPeso molecular:267.28Indole-3-pyruvic acid
CAS:<p>Indole-3-pyruvic acid is a precursor for the plant growth hormone indole-3-acetic acid.</p>Fórmula:C11H9NO3Pureza:98.89% - 99.21%Cor e Forma:Off White CrystalsPeso molecular:203.19VAF347
CAS:<p>VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.</p>Fórmula:C17H11ClF3N3Pureza:98.75% - 99.55%Cor e Forma:SolidPeso molecular:349.745-fluoro 203
CAS:5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts.Fórmula:C14H11FN2SPureza:97.61%Cor e Forma:SolidPeso molecular:258.31Indole-3-carbinol
CAS:<p>Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase</p>Fórmula:C9H9NOPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:147.17Benzyl butyl phthalate
CAS:<p>Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC.</p>Fórmula:C19H20O4Pureza:99.02%Cor e Forma:Colourless Liquid Oily LiquidPeso molecular:312.36FICZ
CAS:<p>FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).</p>Fórmula:C19H12N2OPureza:98.97%Cor e Forma:SolidPeso molecular:284.31CH-223191
CAS:<p>CH-223191, a specific aryl hydrocarbon receptor (AhR) antagonist, inhibited TCDD-induced luciferase activity with an IC50 of 0.03 μM. High-Quality, Low-Cost!</p>Fórmula:C19H19N5OPureza:99.01% - 99.71%Cor e Forma:SolidPeso molecular:333.39L-Kynurenine
CAS:<p>L-Kynurenine ((S)-Kynurenine)) is an endogenous agonist of aryl hydrocarbon receptor (AHR) ,inhibits allogeneic T cell proliferation. High-Quality, Low-Cost!</p>Fórmula:C10H12N2O3Pureza:98.44% - 99.91%Cor e Forma:Light Yellow CrystallinePeso molecular:208.21BAY-218
CAS:<p>Bindarit (AF2838) is an aryl hydrocarbon receptor (AHR) antagonist.Cost-effective and quality-assured.</p>Fórmula:C20H17ClFN3O3Pureza:99.46% - 99.85%Cor e Forma:SolidPeso molecular:401.82Carbidopa
CAS:<p>Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM).</p>Fórmula:C10H14N2O4Pureza:98.01% - ≥98%Cor e Forma:SolidPeso molecular:226.23Tapinarof
CAS:<p>Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.</p>Fórmula:C17H18O2Pureza:99.64% - >99.99%Cor e Forma:SolidPeso molecular:254.32PDM11
CAS:<p>PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR)</p>Fórmula:C16H15ClO2Pureza:99.88%Cor e Forma:SolidPeso molecular:274.74ITE
CAS:<p>ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.</p>Fórmula:C14H10N2O3SPureza:97.91% - 99.14%Cor e Forma:SolidPeso molecular:286.31CAY 10465
CAS:<p>CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).</p>Fórmula:C15H9Cl2F3Pureza:98.80%Cor e Forma:SolidPeso molecular:317.13StemRegenin 1
CAS:<p>StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor.</p>Fórmula:C24H23N5OSPureza:98% - 99.89%Cor e Forma:SolidPeso molecular:429.54PDM2
CAS:<p>PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.</p>Fórmula:C14H9Cl3Pureza:99.44%Cor e Forma:SolidPeso molecular:283.58Skatole
CAS:<p>Skatole (3-Methyl-1H-indole), produced by bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.</p>Fórmula:C9H9NPureza:99.74%Cor e Forma:Leaves From Petroleum Ether; White-Brown Scales SolidPeso molecular:131.17Brevifolincarboxylic acid
CAS:<p>Natural α-glucosidase inhibitor from Polygonum capitatum; blocks AhR with 323.46 μM IC50.</p>Fórmula:C13H8O8Pureza:99.42% - 99.59%Cor e Forma:SolidPeso molecular:292.21,4-Chrysenequinone
CAS:<p>1,4-Chrysenequinone (Chrysene-1,4-dione) is an activator of aryl hydrocarbon receptor (AhR).</p>Fórmula:C18H10O2Pureza:99.07% - 99.84%Cor e Forma:SolidPeso molecular:258.27Pifithrin-α hydrobromide
CAS:<p>Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.</p>Fórmula:C16H18N2OS·HBrPureza:97.71% - >99.99%Cor e Forma:SolidPeso molecular:367.3YL-109
CAS:<p>YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.</p>Fórmula:C14H11NO2SPureza:99.77% - ≥95%Cor e Forma:SolidPeso molecular:257.31DiMNF
CAS:<p>Imigliptin (KBP 3853) is a dipeptidyl peptidase-4 inhibitor used in the study of type 2 diabetes.</p>Fórmula:C21H16O4Pureza:97.60%Cor e Forma:SolidPeso molecular:332.35L-Kynurenine-d4
CAS:<p>L-Kynurenine-d4 is a deuterated isotope compound of L-Kynurenine. L-Kynurenine is a metabolite of tryptophan and an endogenous agonist of the AHR.</p>Fórmula:C10H8D4N2O3Cor e Forma:SolidPeso molecular:212.24D-Kynurenine
CAS:<p>D-Kynurenine, ZINC901103, metabolizes from D-tryptophan, activates AhR, changes epithelium to mesenchyme, and tests for D-amino acid oxidase.</p>Fórmula:C10H12N2O3Pureza:99.68%Cor e Forma:SolidPeso molecular:208.21Phortress
CAS:<p>Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor</p>Fórmula:C20H25Cl2FN4OSPureza:99.89%Cor e Forma:SolidPeso molecular:459.41Prochloraz
CAS:<p>Prochloraz: broad-spectrum imidazole fungicide; blocks placental aromatase (IC50=40nM), estrogen/androgen receptors; activates aryl hydrocarbon receptors.</p>Fórmula:C15H16Cl3N3O2Pureza:99.75% - 99.79%Cor e Forma:Colorless SolidPeso molecular:376.67CAY10464
CAS:<p>CAY10464 (AHR antagonist 7) is an AHR antagonist for the study of cancer and metabolic diseases.</p>Fórmula:C15H12Cl2OPureza:99.96%Cor e Forma:SolidPeso molecular:279.16AhR agonist 2
<p>AhR agonist 2 is aryl hydrocarbon receptor (AhR) agonist,oral, inducing rapid nuclear enrichment of the AhR and facilitating skin barrier repair,psoriasis.</p>Fórmula:C12H7Br2N3Cor e Forma:SolidPeso molecular:353.01
