Lipoxigenase
As lipoxigenases são uma família de enzimas que catalisam a oxigenação de ácidos graxos poli-insaturados, levando à produção de mediadores lipídicos bioativos, como os leucotrienos e as lipoxinas. Esses mediadores desempenham papéis críticos na inflamação, nas respostas imunes e no câncer. Inibidores de lipoxigenase são utilizados para estudar seu papel em doenças inflamatórias, asma e câncer. Na CymitQuimica, oferecemos uma variedade de inibidores de lipoxigenase para apoiar sua pesquisa em inflamação, oncologia e metabolismo lipídico.
Foram encontrados 133 produtos de "Lipoxigenase"
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2-TEDC
CAS:2-TEDC: Potent LOX inhibitor, blocks 5-LOX, 12-LOX, 15-LOX (IC50: 0.09, 0.013, 0.5 μM); aids atherosclerosis research.Fórmula:C16H13NO4SPureza:99.97%Cor e Forma:SolidPeso molecular:315.34LY 269415
CAS:LY 269415 is an anti-inflammatory agent with antioxidant properties in vitro and could be beneficial as therapeutic agents in inflammatory arthritis.Fórmula:C19H28N2O2SCor e Forma:SolidPeso molecular:348.5Butibufen
CAS:Butibufen (FF-106) is a non-steroidal anti-inflammatory compound and LOX inhibitor with analgesic and antipyretic activity for the study of rheumatic diseases.Fórmula:C14H20O2Pureza:98.11% - 98.91%Cor e Forma:SolidPeso molecular:220.315-LOX-IN-1
CAS:5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.
Fórmula:C20H18N2O2SPureza:97.45%Cor e Forma:SolidPeso molecular:350.43A-69412
CAS:A-69412 is a reversible 5-lipoxygenase inhibitor, potentially treating ulcerative colitis and asthma.Fórmula:C7H10N2O3Pureza:99.54%Cor e Forma:SolidPeso molecular:170.17Lonapalene
CAS:Lonapalene is a topically effective inhibitor of 5-lipoxygenase.Fórmula:C16H15ClO6Pureza:98.67% - 99.33%Cor e Forma:SolidPeso molecular:338.74Ref: TM-T16802
1mg100,00€2mg160,00€5mg290,00€10mg424,00€25mg642,00€50mg858,00€100mg1.153,00€200mg1.558,00€1mL*10mM (DMSO)318,00€A 78773
CAS:A 78773: potent reversible 5-lipoxygenase inhibitor; active in cells/tissues; targets inflammation, asthma, IBD.Fórmula:C15H13FN2O4Cor e Forma:SolidPeso molecular:304.27MLS000545091
CAS:MLS000545091 is a potent and selective human epithelial 15-lipoxygenase-2 mixed-type inhibitor.Fórmula:C14H15ClN2OPureza:99.84%Cor e Forma:SolidPeso molecular:262.731-Stearoyl-2-Oleoyl-3-Linoleoyl-rac-glycerol
CAS:1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol is a triacylglycerol consisting of stearic acid, oleic acid, and linoleic acid esterified at the sn-1, sn-2, and sn-3 positions, respectively. This compound is present in peanut and soybean oils as well as in ostrich and emu oils. Additionally, it serves as a substrate for soybean lipoxygenase in cell-free assays.Fórmula:C57H104O6Cor e Forma:SolidPeso molecular:885.4317(S)-HpDHA
CAS:17(S)-HpDHA, primarily produced by the 15-Lipoxygenase (LOX) isoenzymes h15-LOX-1 and h15-LOX-2 from docosahexaenoic acid (DHA), is a key regulator in epoxide synthesis through allosteric modulation. Additionally, it effectively inhibits platelet aggregation, demonstrating an EC50 of approximately 1 μM [1].Fórmula:C22H32O4Cor e Forma:SolidPeso molecular:360.49CMI-392
CAS:CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM).Fórmula:C31H37ClN2O8SPureza:98%Cor e Forma:SolidPeso molecular:633.1515(S)-HEDE
CAS:15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 μM.Fórmula:C20H36O3Cor e Forma:SolidPeso molecular:324.5Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Fórmula:C16H12ClNO3Pureza:98.87%Cor e Forma:SolidPeso molecular:301.72Ref: TM-T19679
1mg202,00€5mg472,00€10mg707,00€25mg1.035,00€50mg1.311,00€100mg1.663,00€1mL*10mM (DMSO)469,00€TA-270
CAS:TA-720, a 5-lipoxygenase inhibitor, is used potentially for the treatment of asthma.Fórmula:C29H36N2O7Cor e Forma:SolidPeso molecular:524.61L 670630
CAS:L 670630 is a potent and orally active 5-lipoxygenase inhibitor.Fórmula:C25H26O3Pureza:98%Cor e Forma:SolidPeso molecular:374.47A 79175
CAS:A 79175 is a 5-lipoxygenase inhibitor that increases bone formation.Fórmula:C15H13FN2O4Pureza:98%Cor e Forma:SolidPeso molecular:304.275-Lipoxygenase-In-1
CAS:5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.Fórmula:C23H28N4O2SCor e Forma:SolidPeso molecular:424.56h15-LOX-2 inhibitor 1
CAS:Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].Fórmula:C17H13F3N2SPureza:98%Cor e Forma:SolidPeso molecular:334.36(2E,9Z)-Octadeca-2,9-dienoic acid
CAS:(2E,9Z)-Octadeca-2,9-dienoic acid, a polyunsaturated fatty acid, is utilized in the study of lipoxygenase-dependent metabolism [1].Fórmula:C18H32O2Cor e Forma:SolidPeso molecular:280.455,6-dehydro Arachidonic Acid
CAS:5,6-dehydro Arachidonic acid, an arachidonic acid analog with a 5,6 acetylene, inhibits 5-LO; Ki=15 μM in RBL cells, IC50=10 μM in guinea pig leukocytes.Fórmula:C20H30O2Cor e Forma:SolidPeso molecular:302.45AA 863
CAS:AA 863 is a 5-lipoxygenase inhibitor, it inhibits the proliferation of human glioma cell lines in dose-dependent.Fórmula:C21H26O5Pureza:98%Cor e Forma:SolidPeso molecular:358.43Setileuton
CAS:Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
Fórmula:C22H17F4N3O4Pureza:98.85% - 99.35%Cor e Forma:SolidPeso molecular:463.38CCT365623
CAS:CCT365623: oral Lysyl Oxidase inhibitor, potent, selective, good pharmacokinetics, anti-metastatic.Fórmula:C18H17NO4S3Pureza:97.299% - 97.63%Cor e Forma:SolidPeso molecular:407.53Ref: TM-T26969
1mg86,00€5mg180,00€10mg245,00€25mg374,00€50mg504,00€100mg662,00€200mg875,00€1mL*10mM (DMSO)225,00€PXS-6302 hydrochloride
CAS:PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3
Fórmula:C10H11ClF3NO2SPureza:99.89%Cor e Forma:SoildPeso molecular:301.71Lobaric acid
CAS:Lobaric acid, from Stereocaulon lichen, has antioxidant and anticancer properties, inhibits PTP1B and 12(S)-LOX, and reduces TMV lesions in plants.Fórmula:C25H28O8Cor e Forma:SolidPeso molecular:456.48h15-LOX-2 inhibitor 3
CAS:Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.Fórmula:C22H13N5O3Cor e Forma:SolidPeso molecular:395.37AZD 4407
CAS:AZD 4407 is a potent inhibitor of 5-lipoxygenase.Fórmula:C19H21NO3S2Pureza:98%Cor e Forma:SolidPeso molecular:375.5L 691816
CAS:L 691816 is an effective inhibitor of the 5-LO reaction.Fórmula:C36H35ClN6OSPureza:98%Cor e Forma:SolidPeso molecular:635.225-LOX/MAOs-IN-1
CAS:Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.Fórmula:C18H18N2O2Cor e Forma:SolidPeso molecular:294.35Resolvin E2
CAS:RvE2, a bioactive lipid from the SPM family, is made from EPA and reduces inflammatory neutrophil infiltration and helps treat NAFLD and other diseases.Fórmula:C20H30O4Cor e Forma:SolidPeso molecular:334.45ALOX15-IN-1
ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.Fórmula:C24H31N3O5SCor e Forma:SolidPeso molecular:473.59ALOX15-IN-2
CAS:ALOX15-IN-2: Potent ALOX15 inhibitor. IC50: 1.55 μM for LA; 2.79 μM for AA. Stops linoleic/arachidonic acid oxidation.Fórmula:C23H29N3O4SPureza:99.98%Cor e Forma:SolidPeso molecular:443.56Ref: TM-T62606
1mg46,00€5mg90,00€10mg160,00€25mg313,00€50mg537,00€100mg767,00€500mg1.558,00€1mL*10mM (DMSO)100,00€CJ-13,610
CAS:CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.Fórmula:C22H23N3O2SPureza:99.64%Cor e Forma:SolidPeso molecular:393.5
