Fosfolipase
As fosfolipases são um grupo de enzimas que hidrolisam fosfolipídios em ácidos graxos e outras substâncias lipofílicas, desempenhando um papel crítico na biologia das membranas e na geração de moléculas sinalizadoras. Inibidores de fosfolipases são usados para estudar seu papel em doenças inflamatórias, distúrbios cardiovasculares e neurodegeneração. Esses inibidores também são valiosos na exploração de vias de sinalização lipídica e suas implicações nos mecanismos de doenças. Na CymitQuimica, oferecemos uma variedade de inibidores de fosfolipases para apoiar sua pesquisa em inflamação, metabolismo lipídico e sinalização celular.
Foram encontrados 84 produtos de "Fosfolipase"
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Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43Ref: TM-T4019
1mg38,00€2mg50,00€1mL*10mM (DMSO)63,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Fórmula:C26H28N4O2Pureza:98%Cor e Forma:SolidPeso molecular:428.53trans-Benzylideneacetone
CAS:trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.Fórmula:C10H10OPureza:97.48%Cor e Forma:Light Yellow Low Melting Crystalline MassPeso molecular:146.19Aristolochic acid C
CAS:Aristolochic acid C is a derivative of Aristolochic acid which is a phospholipase A2 inhibitor.Fórmula:C16H9NO7Pureza:99.8%Cor e Forma:White PowderPeso molecular:327.25CAY10650
CAS:CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).Fórmula:C28H25NO6Pureza:97.33%Cor e Forma:SolidPeso molecular:471.5Ref: TM-TQ0105
1mg49,00€5mg114,00€1mL*10mM (DMSO)118,00€10mg172,00€25mg334,00€50mg467,00€100mg620,00€U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Fórmula:C29H40N2O3Pureza:97.50%Cor e Forma:Solid Off-WhitePeso molecular:464.64m-3M3FBS
CAS:m-3M3FBS is a phospholipase C (PLC) activator.Fórmula:C16H16F3NO2SPureza:99.66%Cor e Forma:SolidPeso molecular:343.36Melittin
CAS:Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.Fórmula:C131H229N39O31Pureza:98.37% - 99.92%Cor e Forma:SolidPeso molecular:2846.46Neomycin sulfate
CAS:Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exertFórmula:C23H46N6O13·3H2SO4Pureza:99.4% - 99.88%Cor e Forma:Tan PowderPeso molecular:908.87VU0155056
CAS:VU0155056 is a dual PLD1/2 inhibitor with IC50 < 1 µM in cellular assays, inhibits breast cancer cell invasion.Fórmula:C25H26N4O2Pureza:98.6% - 99.15%Cor e Forma:SolidPeso molecular:414.5LCL521
CAS:LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.Fórmula:C31H52N4O7Pureza:98%Cor e Forma:SolidPeso molecular:592.77Omeprazole Sodium
CAS:Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.Fórmula:C17H18N3NaO3SPureza:99.84%Cor e Forma:Clear In WaterPeso molecular:367.42-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
CAS:2-Decenoylaminoethyl cyclohexylethyl sulfide prevents stress ulcers, stabilizes phospholipase A2 and prostaglandin E2.Fórmula:C20H37NOSPureza:98%Cor e Forma:SolidPeso molecular:339.58ML299
CAS:ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).Fórmula:C23H26BrFN4O2Pureza:98.23%Cor e Forma:SolidPeso molecular:489.38Ref: TM-T8968
100mgA consultar1mL*10mM (DMSO)A consultar500µg101,00€1mg152,00€5mg371,00€10mg558,00€25mg868,00€50mg1.153,00€Lp-PLA2-IN-3
CAS:Lp-PLA2-IN-3: Potent oral inhibitor of human Lp-PLA2 with a 14 nM IC50.Fórmula:C20H13ClF3N3O3SPureza:99.84%Cor e Forma:SolidPeso molecular:467.85Ref: TM-T11874
1mg90,00€2mg132,00€5mg215,00€1mL*10mM (DMSO)220,00€10mg340,00€25mg565,00€50mg797,00€100mg1.063,00€500mg2.142,00€ASM-IN-1
CAS:ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.Fórmula:C16H12BrN3O4Pureza:98%Cor e Forma:SolidPeso molecular:390.19GK187
CAS:GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.Fórmula:C14H15F5O2Cor e Forma:SolidPeso molecular:310.26Ref: TM-T37221
1mg79,00€5mg172,00€1mL*10mM (DMSO)178,00€10mg268,00€25mg510,00€50mg802,00€100mg1.305,00€Halopemide
CAS:Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).Fórmula:C21H22ClFN4O2Pureza:96.57%Cor e Forma:SolidPeso molecular:416.88Giripladib
CAS:Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.
Fórmula:C41H36ClF3N2O4SPureza:99.64%Cor e Forma:SolidPeso molecular:745.25VU0155069
CAS:VU0155069, a selective PLD1 inhibitor (IC50: 46 nM), halts cancer cell migration in transwell assays.Fórmula:C26H27ClN4O2Pureza:99.5%Cor e Forma:SolidPeso molecular:462.97VU0364739
CAS:VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].Fórmula:C26H27FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:446.52Lp-PLA2-IN-13
CAS:Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].Fórmula:C22H17F5N4O4Pureza:98%Cor e Forma:SolidPeso molecular:496.39Lp-PLA2-IN-2
CAS:Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.Fórmula:C19H23FN2O4SPureza:98%Cor e Forma:SolidPeso molecular:394.46Lp-PLA2-IN-14
CAS:Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.Fórmula:C16H14F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:353.37,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
CAS:7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) significantly impacts the response to βA(25-35) stimulation. It reduces the formation of ROS.Fórmula:C22H40O2Cor e Forma:SolidPeso molecular:336.55Varespladib methyl
CAS:Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.Fórmula:C22H22N2O5Pureza:99.42% - 99.97%Cor e Forma:SolidPeso molecular:394.42Ref: TM-T17218
1mg93,00€2mg123,00€5mg200,00€1mL*10mM (DMSO)220,00€10mg319,00€25mg528,00€50mg730,00€100mg999,00€200mg1.333,00€Ecopladib
CAS:Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).Fórmula:C39H33Cl3N2O5SPureza:95.15%Cor e Forma:SolidPeso molecular:748.11Ref: TM-T11149
1mL*10mM (DMSO)A consultar1mg315,00€5mg630,00€10mg850,00€25mg1.234,00€50mg1.693,00€100mg2.305,00€Rilapladib
CAS:Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activatingFórmula:C40H38F5N3O3SPureza:99.92%Cor e Forma:SolidPeso molecular:735.8Ref: TM-T16751
1mg87,00€5mg215,00€10mg349,00€1mL*10mM (DMSO)349,00€25mg537,00€50mg745,00€100mg1.108,00€200mg1.504,00€MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Fórmula:C21H36FO2PCor e Forma:SolidPeso molecular:370.48GK420
CAS:GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.Fórmula:C20H25NO5SCor e Forma:SolidPeso molecular:391.481Ro 23-9358
CAS:Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.Fórmula:C30H51NO6Cor e Forma:SolidPeso molecular:521.729Lp-PLA2-IN-16
CAS:Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1].
Fórmula:C22H17F5N4O3Pureza:98%Cor e Forma:SolidPeso molecular:480.39Ref: TM-T79076
Produto descontinuadoLp-PLA2-IN-12
CAS:Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-
Fórmula:C24H23F2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:467.47Ref: TM-T79010
Produto descontinuadoLp-PLA2-IN-15
CAS:Lp-PLA2-IN-15 (example 2) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential application in Alzheimer's disease research [1].
Fórmula:C22H17F5N4O3Pureza:98%Cor e Forma:SolidPeso molecular:480.39Ref: TM-T79075
Produto descontinuado
