PKM
A Piruvato Quinase M2 (PKM2) é uma isoforma da piruvato quinase que desempenha um papel crucial na glicólise, convertendo fosfoenolpiruvato em piruvato. PKM2 está envolvida na regulação da reprogramação metabólica em células cancerosas, tornando-se um alvo potencial para a terapia do câncer. Inibidores de PKM2 podem alterar as vias metabólicas, reduzir o crescimento tumoral e induzir a morte celular em células cancerígenas. Na CymitQuimica, oferecemos inibidores de PKM2 para apoiar sua pesquisa em metabolismo do câncer, oncologia e desenvolvimento terapêutico.
Foram encontrados 21 produtos para "PKM".
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PKR-IN-2
CAS:PKR-IN-2 is a activator of pyruvate kinase (PKR).Fórmula:C24H28N4O4SPureza:99.14%Cor e Forma:SolidPeso molecular:468.57Ref: TM-T12499
1mg50,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg157,00€25mg250,00€50mg353,00€100mg502,00€ML 083
CAS:ML 083 is an allosteric activator of tumor-associated pyruvate kinase M2, used to study cancer-specific glycolytic regulation and metabolic reprogramming.Fórmula:C19H22N2O7S2Pureza:99.99%Cor e Forma:White SolidPeso molecular:454.52PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Fórmula:C16H19F3O4Peso molecular:332.12354NCGC00188636
CAS:NCGC00188636 is a covalent pyruvate kinase (PYK) inhibitor; blocks nucleotide binding at the active site; used for metabolism and parasite research.Fórmula:C14H9NO4S2Pureza:99.38%Cor e Forma:White SolidPeso molecular:319.36PKCζ/ι pseudosubstrate inhibitor
CAS:PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFórmula:C76H128N30O16Cor e Forma:SolidPeso molecular:1718.02Dimethylaminomicheliolide HCl
CAS:Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvateFórmula:C17H28ClNO3Pureza:99.91%Cor e Forma:SoildPeso molecular:329.86PKM2 inhibitor G
CAS:PKM2 inhibitor G is a inhibitor of pyruvate kinase.Fórmula:C16H15NO3SPureza:99.89%Cor e Forma:SolidPeso molecular:301.36Ref: TM-T67900
1mg109,00€1mL*10mM (DMSO)230,00€5mg243,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Fórmula:C21H15F4N5Cor e Forma:SolidPeso molecular:413.12636Mitapivat
CAS:Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Fórmula:C24H26N4O3SPureza:99.47% - 99.83%Cor e Forma:SolidPeso molecular:450.55TEPP-46
CAS:TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H16N4O2S2Pureza:98.21% - 99.65%Cor e Forma:SolidPeso molecular:372.46Ref: TM-T7214
1mg46,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg137,00€25mg224,00€50mg335,00€100mg500,00€500mg1.099,00€PKM2-IN-1
CAS:PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Fórmula:C18H19NO2S2Pureza:99.49% - 99.68%Cor e Forma:SolidPeso molecular:345.48DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Fórmula:C19H23N3O6S2Pureza:96.96% - 99.28%Cor e Forma:SolidPeso molecular:453.53PKM2 activator 5
CAS:PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Fórmula:C18H19FN2O6S2Pureza:98%Cor e Forma:SolidPeso molecular:442.48PKM2 activator 2
CAS:PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuatesFórmula:C20H18F2N2O4S2Pureza:99.92%Cor e Forma:SolidPeso molecular:452.49Ref: TM-T62758
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg334,00€50mg505,00€100mg760,00€500mg1.513,00€PKM2 agonist-1
CAS:PKM2 agonist-1 (Compound D16) is a potent allosteric activator of PKM2, with an AC50 value of 77 nM. It inhibits angiotensin II-induced smooth muscle cell phenotypic transformation, effectively preventing aortic dissection and reducing mortality.Fórmula:C24H23N5O4S2Peso molecular:509.6Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Fórmula:C24H27ClN4O3SCor e Forma:SolidPeso molecular:487.014PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Fórmula:C24H22N4O2Cor e Forma:SolidPeso molecular:398.457PKR Inhibitor, negative control
CAS:The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.Fórmula:C15H8Cl3NO2Peso molecular:340.59NPD10084
CAS:NPD10084 is an inhibitor that targets the pyruvate kinase M2 subtype (PKM2).Fórmula:C21H19N3O2Pureza:99.34%Cor e Forma:SolidPeso molecular:345.39Ref: TM-T87033
1mgA consultar5mgA consultar50mgA consultar100mgA consultar1mL*10mM (DMSO)A consultar10mg120,00€25mg260,00€Vitamin K5 hydrochloride
CAS:Vitamin K5 hydrochloride is a photosensitizer and antimicrobial agent that functions as a specific inhibitor of pyruvate kinase M2 (PKM2), with IC50 values of 28 μM for PKM2, 191 μM for PKM1, and 120 μM for PKL. Vitamin K5 hydrochloride induces apoptosis in colon 26 cells, supporting its application in infection and cancer research as well as its practical use as a preservative in pharmaceutical, food, and beverage formulations.Fórmula:C11H12ClNOCor e Forma:SolidPeso molecular:209.67Mitapivat sulfate hydrate
CAS:Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.Fórmula:C24H26N4O3S1H2SO43H2OPureza:99.22%Cor e Forma:SolidPeso molecular:526.6
