LRRK2
Os inibidores de LRRK2 são compostos que têm como alvo e inibem a atividade da Leucine-Rich Repeat Kinase 2 (LRRK2), uma enzima envolvida em vários processos celulares, incluindo autofagia, tráfego vesicular e inflamação. As mutações no gene LRRK2 estão associadas a um aumento do risco de desenvolver a doença de Parkinson, tornando o LRRK2 um alvo significativo para a pesquisa em doenças neurodegenerativas. Os inibidores de LRRK2 são cruciais para explorar o papel do LRRK2 na doença de Parkinson e para desenvolver potenciais estratégias terapêuticas. Na CymitQuimica, oferecemos uma seleção de inibidores de LRRK2 para apoiar sua pesquisa em neurodegeneração, sinalização de quinase e desenvolvimento terapêutico.
Foram encontrados 43 produtos de "LRRK2"
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MLi-2
CAS:MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Fórmula:C21H25N5O2Pureza:98.96%Cor e Forma:SolidPeso molecular:379.46Ref: TM-T16115
1mg55,00€2mg84,00€5mg126,00€10mg178,00€25mg409,00€50mg618,00€100mg880,00€1mL*10mM (DMSO)135,00€BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Fórmula:C26H30N6O2Pureza:97.44% - 99.7%Cor e Forma:SolidPeso molecular:458.56Ref: TM-T5428
1mg52,00€2mg74,00€5mg112,00€10mg167,00€25mgA consultar50mgA consultar1mL*10mM (DMSO)138,00€RN277
RN277 is an inhibitor of LRRK2 type II kinase (LRRK2type II kinase). It serves as a cellular tool targeting the inactive state of LRRK2. In vitro, RN277 inhibits LRRK1 kinase activity and the kinase activity of LRRK2, with an IC50 of 70 nM. Additionally, it reduces Rab8a phosphorylation in a dose-dependent manner. RN277 is useful for Parkinson's disease research.Cor e Forma:Odour SolidXL01126
XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.Fórmula:C50H64ClFN10O6S2Cor e Forma:SolidPeso molecular:1019.69JH-XII-03-02
CAS:JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PDFórmula:C43H51N9O10Pureza:98%Cor e Forma:SolidPeso molecular:853.92Nictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Fórmula:C123H193N45O28Cor e Forma:SolidPeso molecular:2750.13RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Cor e Forma:Odour SolidEB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Fórmula:C22H22N8OPureza:99.53%Cor e Forma:SolidPeso molecular:414.46Ref: TM-T39972
1mg66,00€2mg87,00€5mg147,00€10mg215,00€25mg388,00€50mg577,00€100mg820,00€200mg1.099,00€1mL*10mM (DMSO)161,00€CC-3240
CAS:CC-3240 (compound 13), a molecular glue degrader of CaMKK2 based on CC-8977, has an IC50 of 9 nM [1].Fórmula:C52H64N6O7SPeso molecular:917.17LRRK2 inhibitor 1
CAS:LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.Fórmula:C20H23N5O4Pureza:99.98%Cor e Forma:SolidPeso molecular:397.43Ref: TM-T11878
1mg74,00€2mg97,00€5mg160,00€10mg264,00€25mg557,00€50mg944,00€100mg1.491,00€1mL*10mM (DMSO)170,00€CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Fórmula:C22H26Cl2N6O4SPureza:98.21%Cor e Forma:SolidPeso molecular:541.45Ref: TM-T39202
5mg52,00€10mg75,00€25mg135,00€50mg215,00€100mg319,00€200mg449,00€1mL*10mM (DMSO)64,00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Cor e Forma:Odour LiquidPFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
Fórmula:C16H16N6OPureza:98.14% - 99.73%Cor e Forma:SolidPeso molecular:308.34GNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Fórmula:C26H29F4N5O6SCor e Forma:SolidPeso molecular:615.6CZC-25146 hydrochloride
CAS:CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.Fórmula:C22H26ClFN6O4SPureza:98.76%Cor e Forma:SolidPeso molecular:525LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Fórmula:C31H38N8O3Pureza:98% - 98.82%Cor e Forma:SolidPeso molecular:570.69HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Fórmula:C17H20ClN5O3Pureza:99.59%Cor e Forma:SolidPeso molecular:377.83Ref: TM-T7196
2mg35,00€5mg55,00€10mg89,00€25mg161,00€50mg250,00€100mg360,00€200mg512,00€1mL*10mM (DMSO)62,00€GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Fórmula:C14H16F3N7Pureza:98.01% - 99.97%Cor e Forma:SolidPeso molecular:339.32Ref: TM-T6031
1mg44,00€2mg57,00€5mg113,00€10mg177,00€25mg356,00€50mg532,00€100mg760,00€500mg1.558,00€1mL*10mM (DMSO)90,00€PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Fórmula:C14H16N6OPureza:99.06%Cor e Forma:SolidPeso molecular:284.32Ref: TM-T7729
2mg34,00€5mg52,00€10mg75,00€25mg128,00€50mg187,00€100mg290,00€200mg419,00€1mL*10mM (DMSO)52,00€PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Fórmula:C17H15N5OPureza:98.61% - 99.62%Cor e Forma:SolidPeso molecular:305.33
