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LRRK2

LRRK2

Os inibidores de LRRK2 são compostos que têm como alvo e inibem a atividade da Leucine-Rich Repeat Kinase 2 (LRRK2), uma enzima envolvida em vários processos celulares, incluindo autofagia, tráfego vesicular e inflamação. As mutações no gene LRRK2 estão associadas a um aumento do risco de desenvolver a doença de Parkinson, tornando o LRRK2 um alvo significativo para a pesquisa em doenças neurodegenerativas. Os inibidores de LRRK2 são cruciais para explorar o papel do LRRK2 na doença de Parkinson e para desenvolver potenciais estratégias terapêuticas. Na CymitQuimica, oferecemos uma seleção de inibidores de LRRK2 para apoiar sua pesquisa em neurodegeneração, sinalização de quinase e desenvolvimento terapêutico.

Foram encontrados 48 produtos para "LRRK2".

produtos por página.
  • LRRK2-IN-13
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    LRRK2-IN-13

    CAS:
    LRRK2-IN-13 (Compound 13), with an IC50 value of 0.57 nM, serves as an inhibitor of LRRK2 and exhibits properties that allow it to penetrate the brain [1].
    Fórmula:C19H19ClN8O2
    Cor e Forma:Solid
    Peso molecular:426.86

    Ref: TM-T86824

  • LRRK2-IN-14
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    LRRK2-IN-14

    CAS:
    LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2(G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].
    Fórmula:C17H18F3N5O2
    Cor e Forma:Solid
    Peso molecular:381.35

    Ref: TM-T86825

  • (R,R)-LRRK2-IN-7
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    (R,R)-LRRK2-IN-7

    CAS:
    (R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.
    Fórmula:C24H26N6O
    Cor e Forma:Solid
    Peso molecular:414.50

    Ref: TM-TYD-02662

  • LRRK2-IN-16
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    LRRK2-IN-16

    CAS:
    LRRK2-IN-16 (compound 25) is an inhibitor of the LRRK2 kinase with an IC50 value of less than 5 μM. It is applicable for research in neurodegenerative and autoimmune diseases.
    Fórmula:C18H19N5OS
    Cor e Forma:Solid
    Peso molecular:353.441

    Ref: TM-T204380

  • LRRK2-IN-4
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    LRRK2-IN-4

    CAS:
    LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.
    Fórmula:C25H29ClF2N6O2
    Cor e Forma:Solid
    Peso molecular:518.99

    Ref: TM-T63621

  • Logotipo do CymitQuimica
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    LRRK2-IN-5

    LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.
    Fórmula:C24H26F2N4O2S
    Cor e Forma:Solid
    Peso molecular:472.55

    Ref: TM-T63057

  • Logotipo do CymitQuimica
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    LRRK2-IN-6

    LRRK2-IN-6 is an oral, selective LRRK2 inhibitor crossing the blood-brain barrier, targeting GS (IC50: 4.6μM) and WT LRRK2 (IC50: 49μM).
    Fórmula:C23H24F2N4O2S
    Cor e Forma:Solid
    Peso molecular:458.52

    Ref: TM-T62871

  • LRRK2-IN-3
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    LRRK2-IN-3

    CAS:
    LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.
    Fórmula:C25H29ClF2N6O2
    Cor e Forma:Solid
    Peso molecular:518.99

    Ref: TM-T63620