COX
Os inibidores da ciclooxigenase (COX) são compostos que bloqueiam a atividade das enzimas COX, envolvidas na produção de prostaglandinas, mediadores chave da inflamação e dor. Em neurociências, os inibidores de COX são estudados por seu potencial em reduzir a neuroinflamação, que está implicada em várias doenças neurodegenerativas, como a doença de Alzheimer, Parkinson e esclerose múltipla. Ao inibir a COX, esses compostos podem ajudar a mitigar os processos inflamatórios no cérebro e proteger contra danos neuronais. Na CymitQuimica, oferecemos uma variedade de inibidores de COX para apoiar sua pesquisa em neuroinflamação, gestão da dor e doenças neurodegenerativas.
Foram encontrados 592 produtos de "COX"
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COX-2-IN-1
CAS:<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Fórmula:C18H14ClF3N4O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:442.84CAY10416
CAS:CAY10416: dual COX-2/5-LO inhibitor, IC50: COX-2 (50 nM), 5-LO (3 nM); >200x selectivity for COX-2; anti-inflammatory, prostate cancer agent.Fórmula:C29H29FN2O5SCor e Forma:SolidPeso molecular:536.61Insulin levels modulator
CAS:Insulin level regulators can be used to treat diabetes.Fórmula:C21H23N7OSPureza:98%Cor e Forma:SolidPeso molecular:421.52COX-2-IN-28
CAS:COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).Fórmula:C30H27N7S3Cor e Forma:SolidPeso molecular:581.78(-)-Ibuprofenamide
CAS:(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.Fórmula:C13H19NOPureza:98%Cor e Forma:SolidPeso molecular:205.3Naproxcinod
CAS:Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.Fórmula:C18H21NO6Pureza:99.85%Cor e Forma:SolidPeso molecular:347.36GW-406381
CAS:GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.Fórmula:C21H19N3O3SPureza:99.54%Cor e Forma:SolidPeso molecular:393.46ADU-S100
CAS:ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.Fórmula:C20H24N10O10P2S2Pureza:99.83%Cor e Forma:SolidPeso molecular:690.54Anti-inflammatory agent 56
CAS:Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties byFórmula:C21H15F3N4O4SPureza:98%Cor e Forma:SolidPeso molecular:476.43LY 178002
CAS:LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.Fórmula:C18H25NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.46COX/5-LO-IN-1
CAS:COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.Fórmula:C16H15FN2O2SPureza:98%Cor e Forma:SolidPeso molecular:318.37COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Fórmula:C19H12BrN3O2Cor e Forma:SolidPeso molecular:394.22Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53COX-2-IN-14
CAS:<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Fórmula:C18H18N4O6Cor e Forma:SolidPeso molecular:386.364Apricoxib
CAS:<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Fórmula:C19H20N2O3SCor e Forma:SolidPeso molecular:356.44Anti-inflammatory agent 8
CAS:Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.Fórmula:C18H15N5OS2Cor e Forma:SolidPeso molecular:381.47SC57666
CAS:<p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>Fórmula:C18H17FO2SPureza:98.83%Cor e Forma:SolidPeso molecular:316.39COX-2-IN-32
CAS:COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.Fórmula:C25H24O6Pureza:98%Cor e Forma:SolidPeso molecular:420.45Naproxen glucuronide
CAS:Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.Fórmula:C20H22O9Cor e Forma:SolidPeso molecular:406.38COX-2/sEH-IN-1
CAS:COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.Fórmula:C23H18F3N5O3SCor e Forma:SolidPeso molecular:501.48COX-1/2-IN-1
CAS:"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."Fórmula:C15H10BrClN2OCor e Forma:SolidPeso molecular:349.61COX-1/2-IN-3
CAS:COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].Fórmula:C14H8N2O8Cor e Forma:SolidPeso molecular:332.22COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Fórmula:C24H25N5O3S2Cor e Forma:SolidPeso molecular:495.62COX-2-IN-24
CAS:COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.Fórmula:C24H24BrN5O3S2Cor e Forma:SolidPeso molecular:574.51COX-2-IN-19
CAS:COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.Fórmula:C18H18N4O2SCor e Forma:SolidPeso molecular:354.43COX-2/5-LOX-IN-2
CAS:COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.Fórmula:C18H13N3O4S2Cor e Forma:SolidPeso molecular:399.44Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Fórmula:C24H19N3O5SCor e Forma:SolidPeso molecular:461.49APHS
CAS:APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.Fórmula:C15H18O2SCor e Forma:SolidPeso molecular:262.37COX-2-IN-21
CAS:COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.Fórmula:C21H22N6O4Cor e Forma:SolidPeso molecular:422.44SC58451
CAS:SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.Fórmula:C20H19FO2SPureza:>99.99%Cor e Forma:SolidPeso molecular:342.43Enflicoxib
CAS:Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.Fórmula:C16H12F5N3O2SPureza:99.88%Cor e Forma:SolidPeso molecular:405.34Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Fórmula:C13H11ClN2OPureza:99.76%Cor e Forma:SolidPeso molecular:246.69Feprazone
CAS:Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.Fórmula:C20H20N2O2Pureza:99.6% - 99.89%Cor e Forma:SolidPeso molecular:320.39COX-2-IN-20
CAS:COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].Fórmula:C11H9ClFN3O2Cor e Forma:SolidPeso molecular:269.66ATB-337
CAS:S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.Fórmula:C23H15Cl2NO2S3Cor e Forma:SolidPeso molecular:504.47COX-2/5-LOX-IN-3
CAS:<p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>Fórmula:C17H16ClN3O2SCor e Forma:SolidPeso molecular:361.85Pifoxime
CAS:Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.Fórmula:C15H20N2O3Cor e Forma:SolidPeso molecular:276.33COX/5-LOX-IN-1
CAS:Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.Fórmula:C18H30O3Cor e Forma:SolidPeso molecular:294.43Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Fórmula:C13H11N3O4S2Pureza:99.93%Cor e Forma:SolidPeso molecular:337.37L 651896
CAS:L 651896 is an inhibitor of 5-lipoxygenase.Fórmula:C18H18O3Pureza:96.06% - 99.85%Cor e Forma:SolidPeso molecular:282.33Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Fórmula:C20H29NO3Pureza:98.84% - 99.97%Cor e Forma:SolidPeso molecular:331.45SC-75416
CAS:SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.Fórmula:C15H14ClF3O3Pureza:98.67% - 98.67%Cor e Forma:SolidPeso molecular:334.72LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Fórmula:C18H16ClNO4SPureza:98.16%Cor e Forma:SolidPeso molecular:377.84ABT-963
CAS:ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.Fórmula:C22H22F2N2O5SPureza:98% - 99.85%Cor e Forma:SolidPeso molecular:464.48BN-82451 2HCl
CAS:BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.Fórmula:C18H28Cl2N2OSPureza:99.84% - >99.99%Cor e Forma:SolidPeso molecular:391.4S-2474
CAS:S-2474, an inhibitor of COX-2 and 5-lipoxygenase, has anti-inflammatory and neuroprotective activities, and inhibits cell death.Fórmula:C20H31NO3SPureza:99.03%Cor e Forma:SolidPeso molecular:365.53Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Fórmula:C12H9Cl2NO2SPureza:98.53%Cor e Forma:SolidPeso molecular:302.18Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Fórmula:C13H9ClN2O2Pureza:99.02% - 99.86%Cor e Forma:SolidPeso molecular:260.68ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Fórmula:C27H26ClN3O5Pureza:>99.99%Cor e Forma:SolidPeso molecular:507.96Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Fórmula:C27H23ClN2O5Pureza:99.93%Cor e Forma:SolidPeso molecular:490.93Tilomisole
CAS:Tilomisole (Wy 18251) is an oral anti-inflammatory and immunomodulatory benzimidazole thiazole, used in cancer and inflammation research.Fórmula:C17H11ClN2O2SPureza:99.21%Cor e Forma:SolidPeso molecular:342.8Antioxidant agent-15
CAS:<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Fórmula:C19H14O2Pureza:98%Cor e Forma:SolidPeso molecular:274.31(±)11-HEDE
CAS:"(±)11-HEDE, a racemic mixture comprising the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE, is synthesized from eicosadienoic acid via cyclooxygenase (COX) activity and within macrophages."Fórmula:C20H36O3Cor e Forma:SolidPeso molecular:324.54'-Aarboxylic acid imrecoxib
CAS:Imrecoxib-4'-carboxylic acid is a metabolite of Imrecoxib, which acts as a selective COX-II inhibitor [1].Fórmula:C21H21NO5SCor e Forma:SolidPeso molecular:399.46Prostaglandin E2 Ethanolamide
CAS:Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].Fórmula:C22H37NO5Cor e Forma:SolidPeso molecular:395.5411(R)-HEDE
CAS:11(R)-HEDE is synthesized from 11Z,14Z-eicosadienoic acid through a lipoxygenase-type reaction mediated by COX. Spectrophotometric analysis, specifically measuring the absorbance of the conjugated diene in 11(R)-HEDE, serves as an occasional method for quantifying COX activity.Fórmula:C20H36O3Cor e Forma:SolidPeso molecular:324.56-hydroxy Etodolac
CAS:6-Hydroxy Etodolac, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, causes false positives in diazo diagnostic tests for urinary bilirubin.Fórmula:C17H21NO4Cor e Forma:SolidPeso molecular:303.35BW 755C
CAS:BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.Fórmula:C10H10F3N3Pureza:96.52%Cor e Forma:SolidPeso molecular:229.2Kuwanon T
CAS:Kuwanon T, an isoprenylated flavonoid extracted from the root bark of Morus alba, exhibits protective effects against t-BHP-induced oxidative stress, presentingFórmula:C25H26O6Cor e Forma:SolidPeso molecular:422.47Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Fórmula:C16H13F2NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:369.41(-)-Bornyl ferulate
CAS:<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Fórmula:C20H26O4Pureza:98%Cor e Forma:SolidPeso molecular:330.42Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Fórmula:C16H13ClFN3O3SPureza:98.22%Cor e Forma:SolidPeso molecular:381.81Amtolmetin guacil
CAS:Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。Fórmula:C24H24N2O5Pureza:99.85%Cor e Forma:White Needle-Shaped CrystalPeso molecular:420.46Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Fórmula:C16H12ClNO3Pureza:98.87%Cor e Forma:SolidPeso molecular:301.72Thromboxane B3
CAS:Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.Fórmula:C20H32O6Cor e Forma:SolidPeso molecular:368.5Anticancer agent 166
CAS:Compound 166, also referred to as compound 3, exhibits potent anticancer properties, demonstrating significant inhibitory activity against Caco-2 cells with anFórmula:C19H14OSCor e Forma:SolidPeso molecular:290.38XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Fórmula:C24H20N4O2SCor e Forma:SolidPeso molecular:428.51COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Fórmula:C16H17N5O2Cor e Forma:SolidPeso molecular:311.34COX-2-IN-13
COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.Fórmula:C19H18N2O5SCor e Forma:SolidPeso molecular:386.42(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Fórmula:C16H14O3Cor e Forma:SolidPeso molecular:254.28COX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Fórmula:C25H23N5O4S2Cor e Forma:SolidPeso molecular:521.61COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Fórmula:C19H14ClN5S2Cor e Forma:SolidPeso molecular:411.93Ambuic acid
CAS:Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.Fórmula:C19H26O6Cor e Forma:SolidPeso molecular:350.41COX-1/2-IN-2
COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.Fórmula:C15H10ClIN2OCor e Forma:SolidPeso molecular:396.61COX-2-IN-47
CAS:COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.Fórmula:C18H18N2O4Cor e Forma:SolidPeso molecular:326.35Anti-inflammatory agent 9
Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.Fórmula:C18H15N5O2SCor e Forma:SolidPeso molecular:365.41COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Fórmula:C25H21N3O3SCor e Forma:SolidPeso molecular:443.52COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Fórmula:C31H32FN5O2SCor e Forma:SolidPeso molecular:557.68COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Fórmula:C19H19N3O4S2Cor e Forma:SolidPeso molecular:417.5COX-2-IN-6
CAS:COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Fórmula:C20H27NO6SPureza:99.29% - 99.32%Cor e Forma:SoildPeso molecular:409.5Neral
CAS:Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23Sabialimon P
CAS:<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Fórmula:C31H50O4Cor e Forma:SolidPeso molecular:486.73COX-2-IN-12
COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.Fórmula:C17H19NO3Cor e Forma:SolidPeso molecular:285.34COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Cor e Forma:SolidPeso molecular:494.56COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Fórmula:C15H13N3O2S2Cor e Forma:SolidPeso molecular:331.41STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Fórmula:C28H25ClN6O5Cor e Forma:SolidPeso molecular:560.988NLRP3-IN-69
CAS:NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.Fórmula:C25H24O7Cor e Forma:SolidPeso molecular:436.454COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Fórmula:C23H18F4O3SCor e Forma:SolidPeso molecular:450.446COX-2/NO-IN-1
COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.Fórmula:C15H15NO3Cor e Forma:SolidPeso molecular:257.28Soquelitinib
CAS:Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.Fórmula:C25H30N4O4S2Pureza:99.54%Cor e Forma:SolidPeso molecular:514.66Anti-inflammatory agent 10
Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.Fórmula:C17H13BrN4O3S2Cor e Forma:SolidPeso molecular:465.34Racemic Naproxen
CAS:Racemic Naproxen is a biochemical substance.Fórmula:C14H14O3Pureza:98%Cor e Forma:Crystals From Acetone-Hexane White SolidPeso molecular:230.26
