CaMK
Os inibidores da Proteína Quinase Dependente de Cálcio/Calmodulina (CaMK) são compostos especializados que inibem a atividade da CaMK, uma quinase crucial envolvida em uma variedade de processos celulares, particularmente no sistema nervoso. A CaMK é essencial para traduzir sinais de cálcio em várias respostas celulares, incluindo a plasticidade sináptica, a formação de memória e a expressão gênica. A desregulação da atividade da CaMK está associada a vários distúrbios neurológicos, tornando esses inibidores ferramentas valiosas para o estudo da sinalização sináptica, do aprendizado e da memória. Na CymitQuimica, oferecemos inibidores de CaMK de alta qualidade para apoiar sua pesquisa em plasticidade sináptica, função cognitiva e neurofarmacologia.
Foram encontrados 71 produtos de "CaMK"
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CBP501
CAS:CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.Fórmula:C86H122F5N29O17Cor e Forma:SolidPeso molecular:1929.06TIM-063
CAS:TIM-063: ATP-competitive CaMKKα/β inhibitor, cell-permeable, Ki: 0.35/0.2 μM, IC50: 0.63/0.96 μM.Fórmula:C18H9N3O4Cor e Forma:SolidPeso molecular:331.28Ph-HTBA
CAS:Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.Fórmula:C19H18O3Cor e Forma:SolidPeso molecular:294.34Bisindolylmaleimide VII
CAS:Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.Fórmula:C27H27N5O2Cor e Forma:SolidPeso molecular:453.54CK59
CAS:CK59 inhibits CaMKII and several voltage-gated calcium channels, with an IC50 of ~50 μM.Fórmula:C21H37N7O3Pureza:98%Cor e Forma:SolidPeso molecular:435.56RU 45144
CAS:<p>RU 45144 is an estradiol derivative with antiestrogenic activity.</p>Fórmula:C28H37NO3Pureza:98%Cor e Forma:SolidPeso molecular:435.6W-13 hydrochloride
CAS:<p>W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.</p>Fórmula:C14H18Cl2N2O2SPureza:98.51%Cor e Forma:White PowderPeso molecular:349.28HOCPCA
CAS:HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.Fórmula:C6H8O3Pureza:98%Cor e Forma:SolidPeso molecular:128.13CV-159
CAS:CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.Fórmula:C31H34N4O7Pureza:98%Cor e Forma:SolidPeso molecular:574.62W-5 hydrochloride
CAS:<p>W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.</p>Fórmula:C16H23ClN2O2SPureza:99.35%Cor e Forma:Off-White Crystalline SolidPeso molecular:342.88Zaldaride maleate
CAS:Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.Fórmula:C30H32N4O6Pureza:98%Cor e Forma:SolidPeso molecular:544.6W-9 hydrochloride
CAS:<p>W-9 hydrochloride is a calmodulin antagonist.</p>Fórmula:C16H22Cl2N2O2SPureza:98.9%Cor e Forma:SolidPeso molecular:377.33Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Cor e Forma:SolidPeso molecular:687.7Zaldaride (free base)
CAS:Zaldaride (free base) is a calmodulin antagonist.Fórmula:C26H28N4O2Cor e Forma:SolidPeso molecular:428.53CaMKK2-IN-1
CAS:<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Fórmula:C22H22N2O3Peso molecular:362.42CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Fórmula:C14H11ClO4Cor e Forma:SolidPeso molecular:278.69PTCA
CAS:PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.Fórmula:C10H5Cl2NO2SCor e Forma:SolidPeso molecular:274.123FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Fórmula:C18H20N4O4SCor e Forma:SolidPeso molecular:388.44MCB-22-174
CAS:MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).Fórmula:C16H14DCl2N5OS2Peso molecular:429.37BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Fórmula:C29H32N2O5Pureza:99.57%Cor e Forma:SolidPeso molecular:488.57Calmodulin antagonist-1
CAS:<p>Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.</p>Fórmula:C14H18Cl2N2O2SCor e Forma:SolidPeso molecular:349.27
