BACE
Os inibidores de BACE são compostos que têm como alvo a enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), que é crucial para a produção de beta-amiloide, uma proteína associada à formação de placas amiloides na doença de Alzheimer. Ao inibir a BACE, esses compostos visam reduzir a produção de beta-amiloide e seu acúmulo no cérebro, potencialmente retardando a progressão da doença de Alzheimer. Os inibidores de BACE são um foco importante no desenvolvimento de estratégias terapêuticas para doenças neurodegenerativas. Na CymitQuimica, oferecemos inibidores de BACE para apoiar sua pesquisa em doença de Alzheimer, biologia amiloide e neurodegeneração.
Foram encontrados 37 produtos para "BACE".
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Elenbecestat
CAS:Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.Fórmula:C19H18F3N5O2SPureza:99.95%Cor e Forma:White SolidPeso molecular:437.439BACE1-IN-4
CAS:BACE1-IN-4 is a selective BACE1 inhibitor with nanomolar activity and significantly weaker BACE2 inhibition, and can be used for research on amyloid precursor protein secretase biology and Alzheimer's disease-related drug discovery.Fórmula:C21H23F2N5O4S2Pureza:99.66%Cor e Forma:SolidPeso molecular:511.57BACE1 Protein, Human, Recombinant (hFc)
BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:75.2 kDa (predicted, pro-form); 72.6 kDa (predicted, mature-form); 85-100 kDa (reducing condition, due to glycosylation)Anti-BACE1 Antibody-FITC (8D358)
Anti-BACE1 Antibody-FITC (8D358) is a FITC-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-FITC (8D358) can be used in FCM.Cor e Forma:Odour LiquidAnti-BACE1 Antibody-PE (8D358)
Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.Cor e Forma:Odour LiquidAnti-BACE1 Antibody (2J206)
Anti-BACE1 Antibody (2J206) is an antibody targeting BACE1. Anti-BACE1 Antibody (2J206) can be used in ELISA, WB.Cor e Forma:Odour LiquidAnti-BACE1 Antibody (3R945)
Anti-BACE1 Antibody (3R945) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (3R945) can be used in ELISA.Cor e Forma:Odour LiquidAnti-BACE1 Antibody (8D358)
Anti-BACE1 Antibody (8D358) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8D358) can be used in FCM,ICC/IF.Cor e Forma:Odour LiquidBACE1 Protein, Human, Recombinant
BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7.Cor e Forma:Lyophilized PowderPeso molecular:49 kDa (predicted); 65 kDa (reducing condition, due to glycosylation)BACE1 Protein, Human, Recombinant (His)
BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC - > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLCCor e Forma:Lyophilized PowderPeso molecular:49.5 kDa (predicted); 55-70 kDa (reducing condition, due to glycosylation)Aloeresin D
CAS:Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).Fórmula:C29H32O11Pureza:98.11% - 99.57%Cor e Forma:SolidPeso molecular:556.5578Verubecestat
CAS:Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.Fórmula:C17H17F2N5O3SPureza:94.64% - 99.55%Cor e Forma:SolidPeso molecular:409.41Umibecestat HCl
CAS:Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.Fórmula:C19H16Cl2F7N5O2Pureza:99.92%Cor e Forma:White SolidPeso molecular:550.26Tenuifolin
CAS:Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.Fórmula:C36H56O12Pureza:98.71% - 99.90%Cor e Forma:Yellow SolidPeso molecular:680.8226LY2811376
CAS:LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).Fórmula:C15H14F2N4SPureza:97.92% - 99%Cor e Forma:SolidPeso molecular:320.36BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.Fórmula:C75H122N16O29Pureza:99.71%Cor e Forma:SolidPeso molecular:1711.86Sophoflavescenol
CAS:Sophoflavescenol: PDE5 inhibitor (K(i) 0.005 µM), antioxidant, anti-inflammatory, pro-apoptotic, potential antitumor, mild side effects.Fórmula:C21H20O6Pureza:99.65%Cor e Forma:SolidPeso molecular:368.3799LX2343
CAS:LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Fórmula:C22H19ClN2O6SPureza:99.45%Cor e Forma:SolidPeso molecular:474.914LY2886721
CAS:LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.Fórmula:C18H16F2N4O2SPureza:99% - 99.75%Cor e Forma:SolidPeso molecular:390.407Aloenin
CAS:1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.Fórmula:C19H22O10Pureza:99.42% - 99.69%Cor e Forma:SolidPeso molecular:410.372
