BACE
Os inibidores de BACE são compostos que têm como alvo a enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), que é crucial para a produção de beta-amiloide, uma proteína associada à formação de placas amiloides na doença de Alzheimer. Ao inibir a BACE, esses compostos visam reduzir a produção de beta-amiloide e seu acúmulo no cérebro, potencialmente retardando a progressão da doença de Alzheimer. Os inibidores de BACE são um foco importante no desenvolvimento de estratégias terapêuticas para doenças neurodegenerativas. Na CymitQuimica, oferecemos inibidores de BACE para apoiar sua pesquisa em doença de Alzheimer, biologia amiloide e neurodegeneração.
Foram encontrados 37 produtos para "BACE".
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LY2811376
CAS:LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).Fórmula:C15H14F2N4SPureza:99% - 99.01%Cor e Forma:SolidPeso molecular:320.36Ref: TM-T2639
1mg50,00€2mg70,00€5mg116,00€1mL*10mM (DMSO)116,00€10mg195,00€25mg354,00€50mg530,00€100mg758,00€LX2343
CAS:LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Fórmula:C22H19ClN2O6SPureza:99.45%Cor e Forma:SolidPeso molecular:474.91Ref: TM-T4398
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg79,00€25mg130,00€50mg216,00€100mg323,00€200mg447,00€BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.Fórmula:C75H122N16O29Pureza:99.71%Cor e Forma:SolidPeso molecular:1711.86Epiberberine chloride
CAS:Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Fórmula:C20H18ClNO4Pureza:99.89%Cor e Forma:Orange SolidPeso molecular:371.81DSS30
CAS:DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.Fórmula:C16H14ClNO3S2Pureza:99.19% - 99.4%Cor e Forma:SolidPeso molecular:367.87BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Fórmula:C18H14F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.33Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Fórmula:C26H28N4OPureza:98.55%Cor e Forma:SolidPeso molecular:412.53Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Fórmula:C18H14FN5OSPureza:99.27% - 99.87%Cor e Forma:SolidPeso molecular:367.4Ref: TM-T14338
1mg123,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg477,00€25mg954,00€50mg1.279,00€100mg1.728,00€BACE1-IN-2
CAS:BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Fórmula:C19H15F4N5O2Pureza:98%Cor e Forma:SolidPeso molecular:421.35BACE1-IN-5
CAS:BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.Fórmula:C18H16F5N5O2SPureza:98%Cor e Forma:SolidPeso molecular:461.41PF-06751979
CAS:PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Fórmula:C18H19F2N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:455.5AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Fórmula:C22H21F2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:473.5BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Fórmula:C21H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.57Umibecestat
CAS:Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.Fórmula:C19H15ClF7N5O2Pureza:99.88%Cor e Forma:SolidPeso molecular:513.8Ref: TM-T13253
1mg163,00€5mg334,00€1mL*10mM (DMSO)376,00€10mg485,00€25mg807,00€50mg1.099,00€100mg1.485,00€NB-360
CAS:NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Fórmula:C21H19F4N5O2Pureza:99.72%Cor e Forma:SolidPeso molecular:449.4Ref: TM-T12188
1mg104,00€5mg215,00€1mL*10mM (DMSO)235,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€500mg1.783,00€AZD3839 free base
CAS:AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.Fórmula:C24H16F3N5Pureza:99.93% - 99.96%Cor e Forma:White SolidPeso molecular:431.41
