BACE
Os inibidores de BACE são compostos que têm como alvo a enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), que é crucial para a produção de beta-amiloide, uma proteína associada à formação de placas amiloides na doença de Alzheimer. Ao inibir a BACE, esses compostos visam reduzir a produção de beta-amiloide e seu acúmulo no cérebro, potencialmente retardando a progressão da doença de Alzheimer. Os inibidores de BACE são um foco importante no desenvolvimento de estratégias terapêuticas para doenças neurodegenerativas. Na CymitQuimica, oferecemos inibidores de BACE para apoiar sua pesquisa em doença de Alzheimer, biologia amiloide e neurodegeneração.
Foram encontrados 36 produtos de "BACE"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Scoulerine
CAS:<p>Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).</p>Fórmula:C19H21NO4Pureza:98.62%Cor e Forma:SolidPeso molecular:327.37Eslicarbazepine Acetate
CAS:Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.Fórmula:C17H16N2O3Pureza:99.58% - >99.99%Cor e Forma:White To Off-White SolidPeso molecular:296.32Aloeresin D
CAS:<p>Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).</p>Fórmula:C29H32O11Pureza:98.11% - 99.57%Cor e Forma:SolidPeso molecular:556.56Umibecestat HCl
CAS:<p>Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.</p>Fórmula:C19H16Cl2F7N5O2Pureza:99.92%Cor e Forma:SolidPeso molecular:550.26Tenuifolin
CAS:Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.Fórmula:C36H56O12Pureza:97.37% - 99.54%Cor e Forma:SolidPeso molecular:680.82Epiberberine chloride
CAS:Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Fórmula:C20H18ClNO4Pureza:99.89%Cor e Forma:SolidPeso molecular:371.81Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Fórmula:C26H28N4OPureza:98.55%Cor e Forma:SolidPeso molecular:412.53BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Fórmula:C18H14F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:389.33Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Fórmula:C18H14FN5OSPureza:99.21% - 99.77%Cor e Forma:SolidPeso molecular:367.4BACE1-IN-2
CAS:BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Fórmula:C19H15F4N5O2Pureza:98%Cor e Forma:SolidPeso molecular:421.35AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Fórmula:C22H21F2N5O3SPureza:98%Cor e Forma:SolidPeso molecular:473.5PF-06751979
CAS:PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Fórmula:C18H19F2N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:455.5BACE1-IN-5
CAS:<p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.</p>Fórmula:C18H16F5N5O2SPureza:98%Cor e Forma:SolidPeso molecular:461.41BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Fórmula:C21H23F2N5O4S2Pureza:98%Cor e Forma:SolidPeso molecular:511.57Umibecestat
CAS:Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.Fórmula:C19H15ClF7N5O2Pureza:99.88%Cor e Forma:SolidPeso molecular:513.8NB-360
CAS:NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Fórmula:C21H19F4N5O2Pureza:99.72%Cor e Forma:SolidPeso molecular:449.4
