Proteassoma
Os inibidores de proteassoma são compostos que inibem o proteassoma, um grande complexo proteico responsável pela degradação de proteínas indesejadas ou danificadas dentro da célula. A inibição do proteassoma leva ao acúmulo de proteínas, o que pode induzir a parada do ciclo celular e a apoptose, especialmente em células de rápida divisão, como as células cancerosas. Os inibidores de proteassoma são cruciais na pesquisa e terapia do câncer, especialmente no tratamento do mieloma múltiplo e outras malignidades hematológicas. Na CymitQuimica, oferecemos inibidores de proteassoma para apoiar sua pesquisa em oncologia, biologia celular e desenvolvimento de fármacos.
Foram encontrados 83 produtos para "Proteassoma".
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Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Cor e Forma:SolidPeso molecular:429.85ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Fórmula:C17H24BF3N2O4Pureza:97.06%Cor e Forma:SolidPeso molecular:388.19Ref: TM-T12079
1mg109,00€2mg158,00€5mg259,00€1mL*10mM (DMSO)285,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€200mg1.728,00€Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Fórmula:C34H63N5O9Pureza:96.74% - 99.94%Cor e Forma:SolidPeso molecular:685.89RA190
CAS:RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Fórmula:C28H23Cl5N2O2Pureza:97.7%Cor e Forma:SolidPeso molecular:596.76Ref: TM-T13858
1mg54,00€5mg109,00€1mL*10mM (DMSO)142,00€10mg159,00€25mg233,00€50mg414,00€100mg608,00€Gly-Pro-pNA hydrochloride
CAS:Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidaseFórmula:C13H17ClN4O4Pureza:99.84%Cor e Forma:SolidPeso molecular:328.75RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Fórmula:C19H13Cl4NOPureza:98.89% - 99.38%Cor e Forma:Yellow SolidPeso molecular:413.12Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Fórmula:C17H27N3O7SPureza:99.2% - 99.64%Cor e Forma:White CrystalPeso molecular:417.48UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFórmula:C15H12F4N4O2Pureza:98.12%Cor e Forma:SolidPeso molecular:356.27Ref: TM-T13273
1mg50,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg177,00€25mg334,00€50mg505,00€100mg782,00€VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Fórmula:C18H32N4O5SCor e Forma:SolidPeso molecular:416.535LXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.Fórmula:C27H22FN7O6Pureza:99.89%Cor e Forma:SolidPeso molecular:559.51Ref: TM-T39214L
1mg299,00€2mg447,00€5mg563,00€1mL*10mM (DMSO)830,00€10mg897,00€25mg1.324,00€50mg1.791,00€100mg2.412,00€β5i-IN-1
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.Pureza:98%Cor e Forma:Odour SolidPhepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Fórmula:C41H58N6O6Cor e Forma:SolidPeso molecular:730.94Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Cor e Forma:Odour SolidAcetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Fórmula:C142H230N36O44SCor e Forma:SolidPeso molecular:3175.65874Phepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Fórmula:C37H58N6O6Cor e Forma:SolidPeso molecular:682.89Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Fórmula:C48H56N6O10SCor e Forma:SolidPeso molecular:909.06Phepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Fórmula:C38H60N6O6Cor e Forma:SolidPeso molecular:696.92Acetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Fórmula:C142H230N36O44SPureza:98%Cor e Forma:SolidPeso molecular:3177.65DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Cor e Forma:Odour SolidZ-Leu-Leu-Tyr-COCHO
CAS:Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].Fórmula:C30H39N3O7Pureza:98%Cor e Forma:SolidPeso molecular:553.65Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Cor e Forma:SolidPeso molecular:395.38Ref: TM-T9710
1mg92,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€Z-Gly-Pro-Phe-Leu-CHO
CAS:Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) ofFórmula:C30H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:550.65Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Fórmula:C144H231F3N36O46SCor e Forma:SolidPeso molecular:3291.65LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Fórmula:C16H27BN4O3Cor e Forma:SoildPeso molecular:334.22Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Cor e Forma:Odour SolidProtease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarDPP-4-IN-14
DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.Fórmula:C33H27N7O3Cor e Forma:SolidPeso molecular:569.613Phepropeptin B
CAS:Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.Fórmula:C40H56N6O6Cor e Forma:SolidPeso molecular:716.91Calpastatin subdomain B
CAS:Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.Fórmula:C140H227N35O44SPureza:98%Cor e Forma:SolidPeso molecular:3136.57Teneligliptin-D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Fórmula:C22H30N6OSPureza:98%Cor e Forma:SolidPeso molecular:434.63Alogliptin-13CD3
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Fórmula:C18H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:343.45-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Fórmula:C9H8N2OPureza:99.69%Cor e Forma:SolidPeso molecular:160.17H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Fórmula:C13H22F3N3O5Cor e Forma:SolidPeso molecular:357.33VR23
CAS:VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.Fórmula:C19H16ClN5O6SPureza:98.99% - 99.22%Cor e Forma:White SolidPeso molecular:477.8818α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Fórmula:C30H46O4Pureza:98.54% - 99.68%Cor e Forma:SolidPeso molecular:470.68TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Fórmula:C39H37N3O3Pureza:98.2% - 99.97%Cor e Forma:White SolidPeso molecular:595.73Ixazomib citrate
CAS:Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).Fórmula:C20H23BCl2N2O9Pureza:98.37% - >99.99%Cor e Forma:White SolidPeso molecular:517.12MG-132
CAS:MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!Fórmula:C26H41N3O5Pureza:95% - 99.99%Cor e Forma:SolidPeso molecular:475.62Ref: TM-T2154
1mL*10mM (DMSO)44,00€10mg46,00€25mg84,00€50mg137,00€100mg205,00€200mg356,00€500mg447,00€Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Fórmula:C4H4N2O5Pureza:99.01% - 99.42%Cor e Forma:SolidPeso molecular:160.09Vepdegestrant
CAS:Vepdegestrant(ARV-471 ) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.Fórmula:C45H49N5O4Pureza:97.15% - >99.99%Cor e Forma:SolidPeso molecular:723.9Calpeptin
CAS:Calpeptin is a potent, cell-permeable calpain inhibitor.Fórmula:C20H30N2O4Pureza:97.06% - 98.33%Cor e Forma:SolidPeso molecular:362.46PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Fórmula:C22H26N4O3Pureza:98.82%Cor e Forma:SolidPeso molecular:394.474'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFórmula:C15H12O2Pureza:99.86% - 99.87%Cor e Forma:SolidPeso molecular:224.25ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Fórmula:C31H40N4O7Pureza:98.24% - 99.31%Cor e Forma:SolidPeso molecular:580.67Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Fórmula:C19H25BN4O4Pureza:97.79% - >99.99%Cor e Forma:White SolidPeso molecular:384.24Ref: TM-T2399
5mg50,00€1mL*10mM (DMSO)50,00€10mg60,00€25mg75,00€50mg92,00€100mg137,00€200mg213,00€500mg353,00€Epoxomicin
CAS:Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.Fórmula:C28H50N4O7Pureza:98.65% - 98.86%Cor e Forma:SolidPeso molecular:554.72Ref: TM-T6830
1mg118,00€5mg295,00€1mL*10mM (DMSO)355,00€10mg475,00€25mg773,00€50mg1.071,00€100mg1.423,00€500mg2.862,00€Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Fórmula:C40H57N5O7Pureza:99.6% - 99.84%Cor e Forma:White SolidPeso molecular:719.91MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Fórmula:C22H26N2O4Pureza:95.06%Cor e Forma:SolidPeso molecular:382.45Ref: TM-T2470
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)75,00€10mg90,00€25mg128,00€50mg167,00€100mg284,00€ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Fórmula:C32H22O10Pureza:98% - 99.75%Cor e Forma:Yellow SolidPeso molecular:566.51Oprozomib
CAS:Oprozomib inhibits 20S proteasome β5/LMP7, is orally available, and may have cancer-fighting properties. IC50: β5 - 36 nM; LMP7 - 82 nM.Fórmula:C25H32N4O7SPureza:98% - 99.87%Cor e Forma:White SolidPeso molecular:532.61
