Proteassoma
Os inibidores de proteassoma são compostos que inibem o proteassoma, um grande complexo proteico responsável pela degradação de proteínas indesejadas ou danificadas dentro da célula. A inibição do proteassoma leva ao acúmulo de proteínas, o que pode induzir a parada do ciclo celular e a apoptose, especialmente em células de rápida divisão, como as células cancerosas. Os inibidores de proteassoma são cruciais na pesquisa e terapia do câncer, especialmente no tratamento do mieloma múltiplo e outras malignidades hematológicas. Na CymitQuimica, oferecemos inibidores de proteassoma para apoiar sua pesquisa em oncologia, biologia celular e desenvolvimento de fármacos.
Foram encontrados 72 produtos para "Proteassoma".
Filtrar por
Percentagem de pureza
0
100
|
0
|
50
|
90
|
95
|
100
- Preços em ordem crescente
- Preços em ordem decrescente
- Menor grau de pureza
- Maior grau de pureza
- Estimativa de entrega mais rápida
Biotin-(Oaa)3-epoxomicin
CAS:Biotin-(Oaa)3-epoxomicin (Compound 13) is the biotinylated active form of Epoxomicin. It serves as a high-affinity probe targeting the proteasome. Biotin-(Oaa)3-epoxomicin can covalently bind to multiple proteasome catalytic subunits, such as LMP7, Z, and MECL1.Fórmula:C54H95N9O11SPeso molecular:1078.47Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Cor e Forma:Odour SolidPhepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Fórmula:C37H58N6O6Cor e Forma:SolidPeso molecular:682.89Ac-Nle-Pro-Nle-Asp-AMC
CAS:Ac-Nle-Pro-Nle-Asp-AMC: 26S proteasome substrate for caspase-like activity analysis.Fórmula:C33H45N5O9Peso molecular:655.7385Suc-Leu-Leu-Val-Tyr-AMC
CAS:Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic tetrapeptide substrate for 20S proteasome and chymotrypsin-like proteases, used in drug screening.Fórmula:C40H53N5O10Pureza:98%Cor e Forma:SolidPeso molecular:763.8763Bz-VGR-AMC
CAS:Bz-VGR-AMC is a substrate for the 20S proteasome (20Sproteasome), used to measure the chymotrypsin-like (β2) activity of the 20S proteasome.Fórmula:C30H37N7O6Peso molecular:591.67Anticancer agent 233
Anticanceragent 233 (compound 5g) is a 3,5-bis(arylmethyl)-4-piperidone derivative exhibiting anticancer activity, with GI50 values of 0.25 and 0.23 μM against cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chloro substituents on the aryl ring of Anticanceragent 233 interact effectively with the catalytic site of the 20S proteasome, inhibiting its activity to deliver its anticancer effects.Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Cor e Forma:SolidPeso molecular:395.38375-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Fórmula:C9H8N2OPureza:99.69%Cor e Forma:SolidPeso molecular:160.1726(R)-MG-132
CAS:(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.Fórmula:C27H43N3O5Pureza:99.90%Cor e Forma:SolidPeso molecular:489.6474VR23
CAS:VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.Fórmula:C19H16ClN5O6SPureza:98.99% - 99.22%Cor e Forma:White SolidPeso molecular:477.878TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Fórmula:C39H37N3O3Pureza:98.2% - 99.97%Cor e Forma:White SolidPeso molecular:595.7294Ixazomib citrate
CAS:Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).Fórmula:C20H23BCl2N2O9Pureza:98.37% - >99.99%Cor e Forma:White SolidPeso molecular:517.122MG-132
CAS:MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!Fórmula:C26H41N3O5Pureza:95% - 99.99%Cor e Forma:SolidPeso molecular:475.62Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Fórmula:C4H4N2O5Pureza:99.01% - 99.42%Cor e Forma:SolidPeso molecular:160.085Vepdegestrant
CAS:Vepdegestrant(ARV-471 ) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.Fórmula:C45H49N5O4Pureza:97.15% - >99.99%Cor e Forma:SolidPeso molecular:723.9Calpeptin
CAS:Calpeptin is a potent, cell-permeable calpain inhibitor.Fórmula:C20H30N2O4Pureza:97.06% - 99.46%Cor e Forma:SolidPeso molecular:362.46PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Fórmula:C22H26N4O3Pureza:98.82%Cor e Forma:SolidPeso molecular:394.46684'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFórmula:C15H12O2Pureza:99.86% - 99.87%Cor e Forma:SolidPeso molecular:224.2546ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Fórmula:C31H40N4O7Pureza:98.24% - 99.31%Cor e Forma:SolidPeso molecular:580.6719
