Proteassoma
Os inibidores de proteassoma são compostos que inibem o proteassoma, um grande complexo proteico responsável pela degradação de proteínas indesejadas ou danificadas dentro da célula. A inibição do proteassoma leva ao acúmulo de proteínas, o que pode induzir a parada do ciclo celular e a apoptose, especialmente em células de rápida divisão, como as células cancerosas. Os inibidores de proteassoma são cruciais na pesquisa e terapia do câncer, especialmente no tratamento do mieloma múltiplo e outras malignidades hematológicas. Na CymitQuimica, oferecemos inibidores de proteassoma para apoiar sua pesquisa em oncologia, biologia celular e desenvolvimento de fármacos.
Foram encontrados 94 produtos de "Proteassoma"
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DD1
CAS:<p>DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.</p>Fórmula:C16H14N2O3Pureza:99.57%Cor e Forma:SolidPeso molecular:282.29Tripterin
CAS:<p>Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.</p>Fórmula:C29H38O4Pureza:98.56% - 99.8%Cor e Forma:Red Crystalline PowderPeso molecular:450.61Cilastatin
CAS:<p>Cilastatin (MK0791): protects imipenem from renal breakdown; inhibits leukotriene D4 metabolism.</p>Fórmula:C16H26N2O5SPureza:97.76% - 99.71%Cor e Forma:SolidPeso molecular:358.45Proteasome inhibitor IX
CAS:<p>Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).</p>Fórmula:C20H21B2NO5Pureza:99.77%Cor e Forma:SolidPeso molecular:377.01VR23
CAS:<p>VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.</p>Fórmula:C19H16ClN5O6SPureza:98.99% - 99.22%Cor e Forma:SolidPeso molecular:477.88Anagliptin
CAS:<p>Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.</p>Fórmula:C19H25N7O2Pureza:97.59% - 99.98%Cor e Forma:SolidPeso molecular:383.45Ixazomib
CAS:<p>Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.</p>Fórmula:C14H19BCl2N2O4Pureza:98% - 98.92%Cor e Forma:SolidPeso molecular:361.03Trelagliptin succinate
CAS:<p>Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (</p>Fórmula:C22H26FN5O6Pureza:99.27% - 99.92%Cor e Forma:SolidPeso molecular:475.47(R)-MG-132
CAS:<p>(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.</p>Fórmula:C26H41N3O5Pureza:98.45%Cor e Forma:SolidPeso molecular:475.62Delanzomib
CAS:<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Fórmula:C21H28BN3O5Pureza:95.52% - 99.46%Cor e Forma:SolidPeso molecular:413.28Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Fórmula:C16H15F6N5O·H3PO4·H2OPureza:99.85% - 99.98%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:523.33KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Fórmula:C21H23N3O6Cor e Forma:SolidPeso molecular:413.42Diprotin B
CAS:<p>Diprotin B is a dipeptidyl peptidase IV inhibitor.</p>Fórmula:C16H29N3O4Pureza:98%Cor e Forma:White Lyophilized PowderPeso molecular:327.42Gemigliptin Tartrate(911637-19-9 free base)
CAS:<p>Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4).</p>Fórmula:C22H25F8N5O8Pureza:>99.99%Cor e Forma:SolidPeso molecular:639.45BC-23
CAS:<p>BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.</p>Fórmula:C21H14ClN3O4SPureza:98%Cor e Forma:SolidPeso molecular:439.87Z-LLF-CHO
CAS:<p>Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.</p>Fórmula:C29H39N3O5Pureza:98%Cor e Forma:SolidPeso molecular:509.64Proteasome-IN-1
CAS:<p>Proteasome-IN-1 is an inhibitor of proteasome.</p>Fórmula:C42H35N5O3Pureza:98%Cor e Forma:SolidPeso molecular:657.7620S Proteasome activator 1
CAS:<p>20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.</p>Fórmula:C27H19ClF2N2OSPureza:99.82%Cor e Forma:SolidPeso molecular:492.97Gemigliptin
CAS:<p>Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)</p>Fórmula:C18H19F8N5O2Pureza:99.72%Cor e Forma:SolidPeso molecular:489.36Arimoclomol
CAS:<p>Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (</p>Fórmula:C14H20ClN3O3Pureza:99.15%Cor e Forma:SolidPeso molecular:313.78
