p97
Os inibidores de p97 são compostos que inibem p97, também conhecido como Proteína Contenedora de Valosina (VCP), uma ATPase envolvida em vários processos celulares, incluindo a degradação de proteínas, regulação do ciclo celular e reparo do DNA. p97 desempenha um papel crucial no sistema ubiquitina-proteassoma, e sua inibição é de grande interesse na pesquisa do câncer, doenças neurodegenerativas e outros distúrbios onde a homeostase proteica é perturbada. Na CymitQuimica, oferecemos inibidores de p97 para apoiar sua pesquisa em proteostasia, neurobiologia e terapia contra o câncer.
Foram encontrados 15 produtos de "p97"
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UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C23H16ClN3O3SCor e Forma:SolidPeso molecular:449.91UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SCor e Forma:SolidPeso molecular:430.86UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Cor e Forma:SolidPeso molecular:344.8MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Cor e Forma:SolidPeso molecular:462.55CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:95.95% - 99.92%Cor e Forma:SolidPeso molecular:413.47Ref: TM-T6796
1mg43,00€2mg56,00€5mg93,00€10mg130,00€25mg281,00€50mg444,00€100mg650,00€500mg1.369,00€1mL*10mM (DMSO)92,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Cor e Forma:SolidPeso molecular:408.92ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Fórmula:C23H24N4OPureza:98%Cor e Forma:SolidPeso molecular:372.46ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:99.73% - >99.99%Cor e Forma:SolidPeso molecular:396.44Ref: TM-T3535
1mg35,00€2mg50,00€5mg77,00€10mg105,00€25mg178,00€50mg295,00€100mg477,00€200mg677,00€1mL*10mM (DMSO)84,00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Cor e Forma:SolidPeso molecular:520.67DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Fórmula:C22H20N4Pureza:98.93% - ≥95%Cor e Forma:SolidPeso molecular:340.42Ref: TM-T1969
2mg34,00€5mg52,00€10mg85,00€25mg152,00€50mg264,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)52,00€NPD8733
CAS:NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.
Fórmula:C18H15NO4Pureza:98.48%Cor e Forma:SolidPeso molecular:309.32CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
Fórmula:C24H24N6OPureza:97.66%Cor e Forma:SoildPeso molecular:412.49UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:594.68VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Fórmula:C24H23N5O2Cor e Forma:SolidPeso molecular:413.47p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Fórmula:C25H26N6O2Cor e Forma:SolidPeso molecular:442.51
