Protease serina
Os inibidores de serina protease são compostos que inibem as serina proteases, um grupo de enzimas caracterizado por um resíduo de serina no seu sítio ativo. Essas proteases estão envolvidas em vários processos fisiológicos, incluindo digestão, resposta imunológica, coagulação sanguínea e inflamação. Os inibidores de serina protease são importantes para o estudo de doenças onde essas enzimas estão desreguladas, como doenças cardiovasculares, câncer e condições inflamatórias. Na CymitQuimica, oferecemos inibidores de serina protease para apoiar sua pesquisa em enzimologia, mecanismos de doenças e intervenções terapêuticas.
Foram encontrados 54 produtos de "Protease serina"
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ZM223 hydrochloride (2031177-48-5 free base)
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity.Fórmula:C23H18ClF3N4O2S2Pureza:98%Cor e Forma:SolidPeso molecular:538.99Lodelaben
CAS:Lodelaben (Declaben, SC-39026) is a reversible, non-competitive,specific inhibitor of human neutrophil elastase (HNE) with high potency (IC50=0.5 μM).Fórmula:C25H41ClO3Pureza:99.62% - >99.99%Cor e Forma:SolidPeso molecular:425.04ZD8321
CAS:ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).Fórmula:C18H28F3N3O5Pureza:98%Cor e Forma:SolidPeso molecular:423.43APC 366
CAS:APC 366: Mast cell tryptase inhibitor, Ki 7.1 μM. Reduces EAR, LAR, BHR in allergic asthma (sheep model).Fórmula:C22H28N6O4Pureza:99.8%Cor e Forma:SolidPeso molecular:440.5WNK1-IN-1
CAS:WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.Fórmula:C13H15BrCl2N2O4SPureza:98.09%Cor e Forma:SolidPeso molecular:446.14Ref: TM-T73295
1mg71,00€5mg152,00€10mg236,00€25mg485,00€50mg782,00€100mg1.305,00€1mL*10mM (DMSO)167,00€ZD-0892
CAS:ZD-0892: potent, selective neutrophil elastase inhibitor; Ki 6.7 nM (human), 200 nM (porcine).Fórmula:C24H32F3N3O5Pureza:95% - 99.53%Cor e Forma:SolidPeso molecular:499.52IPR-803
CAS:IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.Fórmula:C27H23N3O4Pureza:95%Cor e Forma:SolidPeso molecular:453.49AZD-9819
CAS:AZD-9819 is a neutrophil elastase (HNE) inhibitor applicable for research into chronic obstructive pulmonary disease (COPD).Fórmula:C25H19F3N6O2Pureza:100% - 99.18%Cor e Forma:SolidPeso molecular:492.45LM-030
CAS:LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).Fórmula:C46H72N8O12Cor e Forma:SolidPeso molecular:929.11FK706
CAS:FK706, a human neutrophil elastase inhibitor (IC50: 83 nM, Ki: 4.2 nM), also blocks mouse and porcine elastases. Anti-inflammatory.Fórmula:C26H33F3N4NaO7Cor e Forma:SolidPeso molecular:593.556TMPRSS6-IN-1 TFA
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.Fórmula:C35H41F3N8O6S2Cor e Forma:SolidPeso molecular:790.875MeO-Suc-Ala-Ala-Pro-Ala-CMK
CAS:MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).Fórmula:C20H31ClN4O7Cor e Forma:SolidPeso molecular:474.936Matriptase-IN-2 free base
CAS:Matriptase-IN-2 free base, a matriptase inhibitor with a K i of 5 nM, has potential applications in musculoskeletal system disorder research (WO2011023958A1; compound 432) [1].Fórmula:C29H33Cl2N5O3SCor e Forma:SolidPeso molecular:602.58Feniralstat
CAS:Feniralstat (KVD-824) is a selective and potent kallikrein (kallikrein) inhibitor, useful in immune system diseases and cardiovascular disease research.Fórmula:C26H25F2N5O4Pureza:99.52%Cor e Forma:SolidPeso molecular:509.51
