Glutaminase
Os inibidores de glutaminase são compostos que inibem a glutaminase, uma enzima que catalisa a conversão de glutamina em glutamato, um passo crítico no metabolismo celular, especialmente em células cancerosas. A glutaminase desempenha um papel fundamental na provisão de energia e precursores biossintéticos para células em rápida proliferação. Os inibidores de glutaminase são importantes para explorar dependências metabólicas em células cancerosas e desenvolver potenciais estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores de glutaminase para apoiar sua pesquisa em metabolismo do câncer, bioenergética celular e descoberta terapêutica.
Foram encontrados 40 produtos de "Glutaminase"
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BJJF078
CAS:<p>BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.</p>Fórmula:C27H29N3O6SPureza:98.19%Cor e Forma:SoildPeso molecular:523.6LDN-27219
CAS:<p>LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.</p>Fórmula:C20H16N4O2S2Pureza:99.01% - 99.38%Cor e Forma:SolidPeso molecular:408.5Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Fórmula:C24H23N7O2SPureza:98%Cor e Forma:SolidPeso molecular:473.55L-Methionine-DL-sulfoximine
CAS:<p>MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.</p>Fórmula:C5H12N2O3SPureza:99.56% - ≥98%Cor e Forma:White Crystalline PowderPeso molecular:180.23PROTAC TG2 degrader-1
<p>PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.</p>Fórmula:C55H73N9O10SPureza:98%Cor e Forma:SolidPeso molecular:1052.29PROTAC TG2 degrader-2
<p>PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.</p>Fórmula:C47H57N9O6SPureza:98%Cor e Forma:SolidPeso molecular:876.08LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Fórmula:C26H18Cl2N4O5Peso molecular:536.06543Trivalent hydroxyarsinothricn
<p>Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.</p>Fórmula:C4H10AsNO4Peso molecular:210.982586-Diazo-5-oxo-L-nor-Leucine
CAS:<p>6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).</p>Fórmula:C6H9N3O3Pureza:98.04% - 98.93%Cor e Forma:SolidPeso molecular:171.15GLS1 Inhibitor-7
<p>GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and</p>Fórmula:C20H17F3N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:482.5Glutaminase-IN-1
CAS:<p>Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.</p>Fórmula:C26H24F3N7O3SePureza:98.65% - 98.65%Cor e Forma:SolidPeso molecular:618.47Glutaminase-IN-3
CAS:<p>Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.</p>Fórmula:C19H19F3N6O2SPureza:98.51%Cor e Forma:SolidPeso molecular:452.45Glutaminase C-IN-1
CAS:<p>Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.</p>Fórmula:C27H27BrN2OPureza:99.68% - >99.99%Cor e Forma:SolidPeso molecular:475.42GK921
CAS:<p>GK921 is a transglutaminase 2 (TGase) inhibitor.</p>Fórmula:C21H20N4OPureza:97.44% - 99.49%Cor e Forma:SolidPeso molecular:344.41BPTES
CAS:<p>BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.</p>Fórmula:C24H24N6O2S3Pureza:95.83% - 99.64%Cor e Forma:SolidPeso molecular:524.68Telaglenastat
CAS:<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>Fórmula:C26H24F3N7O3SPureza:97.57% - 99.89%Cor e Forma:SolidPeso molecular:571.57L-Albizziin
CAS:<p>L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.</p>Fórmula:C4H9N3O3Pureza:99.98%Cor e Forma:White PowderPeso molecular:147.13Zampilimab
CAS:<p>Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.</p>Pureza:95%Cor e Forma:LiquidIrbesartan-d4
CAS:<p>Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.</p>Fórmula:C25H28N6OPureza:>99.99%Cor e Forma:SolidPeso molecular:432.55VA4 TG2 inhibitor
CAS:<p>VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.</p>Fórmula:C33H41N5O6SCor e Forma:SolidPeso molecular:635.77
