Wnt/beta-catenina
Os inibidores de Wnt/beta-catenina são compostos que visam e inibem a via de sinalização Wnt/beta-catenina, crucial para a regulação do desenvolvimento embrionário, proliferação celular e manutenção das células-tronco. A desregulação desta via está ligada a vários tipos de câncer e doenças degenerativas. Os inibidores da sinalização Wnt/beta-catenina são valiosos em pesquisas focadas em entender o papel dessa via na doença e no desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos inibidores de Wnt/beta-catenina para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e pesquisa oncológica.
Foram encontrados 66 produtos de "Wnt/beta-catenina"
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CCT251545
CAS:<p>CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).</p>Fórmula:C23H24ClN5OPureza:98.2% - 98.69%Cor e Forma:SolidPeso molecular:421.92TNIK-IN-5
CAS:<p>TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.</p>Fórmula:C22H17N3O3Pureza:99.58%Cor e Forma:SolidPeso molecular:371.39JW74
CAS:<p>JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).</p>Fórmula:C24H20N6O2SPureza:95.00%Cor e Forma:SolidPeso molecular:456.52BML-286
CAS:<p>BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.</p>Fórmula:C22H18N2O4Pureza:98.44%Cor e Forma:SolidPeso molecular:374.39Nefopam hydrochloride
CAS:<p>Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.</p>Fórmula:C17H20ClNOPureza:99.32% - 99.85%Cor e Forma:SolidPeso molecular:289.8KY1220
CAS:<p>KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.</p>Fórmula:C14H10N4O3SPureza:99.9%Cor e Forma:SolidPeso molecular:314.32CWP232228
CAS:<p>CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.</p>Fórmula:C33H34N7Na2O7PPureza:98.87%Cor e Forma:SolidPeso molecular:717.63Vantictumab
CAS:<p>Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.</p>Pureza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Cor e Forma:LiquidRomosozumab
CAS:<p>Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, which increases bone formation and decreases bone resorption.</p>Pureza:98.9% (SDS-PAGE); 98.2% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.2% (SEC-HPLC)Cor e Forma:LiquidWnt pathway inhibitor 3
CAS:<p>Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies</p>Fórmula:C21H17BrN2O5Pureza:99.69%Cor e Forma:SoildPeso molecular:457.27ABC99
CAS:<p>ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.</p>Fórmula:C22H21ClN4O5Pureza:99.89%Cor e Forma:SoildPeso molecular:456.88NLS-StAx-h
<p>Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.</p>Fórmula:C161H275N55O29Pureza:98%Cor e Forma:SolidPeso molecular:3445.26Tabituximab
CAS:<p>BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.</p>Pureza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.5 kDaCarboxylesterase-IN-2
CAS:<p>Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.</p>Fórmula:C13H12N4OSPureza:99.92%Cor e Forma:SoildPeso molecular:272.331(R),2(S)-epoxy Cannabidiol
CAS:<p>1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.</p>Fórmula:C21H30O3Cor e Forma:SolidPeso molecular:330.46Foxy-5
CAS:<p>Foxy-5 is a wnt5a peptide mimetic</p>Fórmula:C26H42N6O12S2Pureza:98%Cor e Forma:SolidPeso molecular:694.77Ipafricept
CAS:<p>Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.</p>Pureza:99.2% (SDS-PAGE); 97.4% (SEC-HPLC) - 99.2% (SDS-PAGE); 97.4% (SEC-HPLC)Cor e Forma:LiquidYW2036
CAS:<p>YW2036 is an inhibitor of Wnt signaling pathway.</p>Fórmula:C20H16N4OPureza:99.94%Cor e Forma:SoildPeso molecular:328.37Wnt/β-catenin agonist 3
CAS:<p>Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.</p>Fórmula:C16H15ClN4O2Pureza:99.52%Cor e Forma:SolidPeso molecular:330.77WIC1
CAS:<p>2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.</p>Fórmula:C22H23N3O3Pureza:99.82%Cor e Forma:SoildPeso molecular:377.44
