Wnt/beta-catenina
Os inibidores de Wnt/beta-catenina são compostos que visam e inibem a via de sinalização Wnt/beta-catenina, crucial para a regulação do desenvolvimento embrionário, proliferação celular e manutenção das células-tronco. A desregulação desta via está ligada a vários tipos de câncer e doenças degenerativas. Os inibidores da sinalização Wnt/beta-catenina são valiosos em pesquisas focadas em entender o papel dessa via na doença e no desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos inibidores de Wnt/beta-catenina para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e pesquisa oncológica.
Foram encontrados 60 produtos de "Wnt/beta-catenina"
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CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Fórmula:C23H24ClN5OPureza:98.29% - 98.69%Cor e Forma:SolidPeso molecular:421.92JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Fórmula:C24H20N6O2SPureza:95.00%Cor e Forma:SolidPeso molecular:456.52BML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Fórmula:C22H18N2O4Pureza:98.44%Cor e Forma:SolidPeso molecular:374.39TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Fórmula:C22H17N3O3Pureza:99.58%Cor e Forma:SolidPeso molecular:371.39KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.
Fórmula:C14H10N4O3SPureza:99.9%Cor e Forma:SolidPeso molecular:314.32Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Pureza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Cor e Forma:LiquidCWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Fórmula:C33H34N7Na2O7PPureza:98.87%Cor e Forma:SolidPeso molecular:717.63Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.88 kDaRomosozumab
CAS:Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, which increases bone formation and decreases bone resorption.Pureza:98.9% (SDS-PAGE); 98.2% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.2% (SEC-HPLC)Cor e Forma:LiquidCCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Fórmula:C23H20BrN3OPureza:99.50%Cor e Forma:SolidPeso molecular:434.33Ref: TM-T21685
1mg38,00€5mg71,00€10mg105,00€25mg207,00€50mg329,00€100mg472,00€200mg620,00€1mL*10mM (DMSO)87,00€Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
Fórmula:C16H15ClN4O2Pureza:99.52%Cor e Forma:SolidPeso molecular:330.77Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Pureza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.5 kDaABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:99.89%Cor e Forma:SoildPeso molecular:456.88Ref: TM-T23602
1mg114,00€2mg155,00€5mg222,00€10mg334,00€25mg595,00€50mg893,00€100mg1.243,00€200mg1.674,00€1mL*10mM (DMSO)224,00€LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Fórmula:C11H9ClN2O2S2Pureza:99.84%Cor e Forma:SolidPeso molecular:300.78YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:99.94%Cor e Forma:SoildPeso molecular:328.37NLS-StAx-h
Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.Fórmula:C161H275N55O29Pureza:98%Cor e Forma:SolidPeso molecular:3445.26Ipafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Pureza:99.2% (SDS-PAGE); 97.4% (SEC-HPLC) - 99.2% (SDS-PAGE); 97.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:41.12 kDaFoxy-5
CAS:Foxy-5 is a wnt5a peptide mimeticFórmula:C26H42N6O12S2Pureza:98%Cor e Forma:SolidPeso molecular:694.771(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Cor e Forma:SolidPeso molecular:330.46WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.
Fórmula:C22H23N3O3Pureza:99.82%Cor e Forma:SoildPeso molecular:377.44
