Wnt/beta-catenina
Os inibidores de Wnt/beta-catenina são compostos que visam e inibem a via de sinalização Wnt/beta-catenina, crucial para a regulação do desenvolvimento embrionário, proliferação celular e manutenção das células-tronco. A desregulação desta via está ligada a vários tipos de câncer e doenças degenerativas. Os inibidores da sinalização Wnt/beta-catenina são valiosos em pesquisas focadas em entender o papel dessa via na doença e no desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos inibidores de Wnt/beta-catenina para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e pesquisa oncológica.
Foram encontrados 80 produtos para "Wnt/beta-catenina".
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Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Pureza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:142.69 kDa (Predicted)LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.Fórmula:C11H9ClN2O2S2Pureza:99.84%Cor e Forma:White SolidPeso molecular:300.784CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Fórmula:C33H34N7Na2O7PPureza:98.87%Cor e Forma:SolidPeso molecular:717.63KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Fórmula:C14H10N4O3SPureza:99.9%Cor e Forma:Yellow SolidPeso molecular:314.319TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Fórmula:C22H17N3O3Pureza:99.58%Cor e Forma:SolidPeso molecular:371.3887CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Fórmula:C23H24ClN5OPureza:98.29% - 98.69%Cor e Forma:White SolidPeso molecular:421.923JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Fórmula:C24H20N6O2SPureza:95.00%Cor e Forma:SolidPeso molecular:456.52BML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Fórmula:C22H18N2O4Pureza:99.3%Cor e Forma:SolidPeso molecular:374.3893Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.88 kDa (Predicted)Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.Fórmula:C16H15ClN4O2Pureza:99.52%Cor e Forma:SolidPeso molecular:330.769Foxy-5
CAS:Foxy-5 is a wnt5a peptide mimeticFórmula:C26H42N6O12S2Pureza:98%Cor e Forma:SolidPeso molecular:694.77Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Pureza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.63 kDa (Predicted)ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:99.89%Cor e Forma:SolidPeso molecular:456.879β-catenin peptide
CAS:β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.Fórmula:C49H76N12O15Pureza:98%Cor e Forma:SolidPeso molecular:1073.2Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.Fórmula:C26H46N7O12S2Pureza:99.26%Cor e Forma:White SolidPeso molecular:712.26NLS-StAx-h
Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.Fórmula:C161H275N55O29Pureza:98%Cor e Forma:SolidPeso molecular:3445.26YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:99.94%Cor e Forma:SolidPeso molecular:328.3672Resugosbart
CAS:Resugosbart (SHR-1222) is a humanized monoclonal antibody that targets and antagonizes SOST (sclerostin) and can be used in ELISA, FACS, and functional experiments. Resugosbart can be used in research on SOST-mediated bone metabolism regulation, anti-SOST antibody activity evaluation, and related mechanisms.Peso molecular:~148 kDaWIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.Fórmula:C22H23N3O3Pureza:99.82%Cor e Forma:Orange SolidPeso molecular:377.4363Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Fórmula:C28H46N6O14S2Pureza:98%Cor e Forma:SolidPeso molecular:754.83
