Células - tronco
Os inibidores de células-tronco são compostos que atuam especificamente nas células-tronco e em suas vias de sinalização, afetando sua capacidade de autorrenovação e diferenciação. Esses inibidores são cruciais em pesquisas focadas no controle do comportamento das células-tronco, na compreensão dos processos de desenvolvimento e no desenvolvimento de terapias para doenças como o câncer, onde se acredita que as células-tronco desempenhem um papel fundamental. Na CymitQuimica, oferecemos uma variedade de inibidores de células-tronco para apoiar sua pesquisa em medicina regenerativa, biologia do desenvolvimento e oncologia.
Foram encontrados 224 produtos de "Células - tronco"
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VT103
CAS:VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Fórmula:C18H17F3N4O2SPureza:99.58%Cor e Forma:SolidPeso molecular:410.41Ref: TM-T62077
1mg112,00€5mg268,00€10mg424,00€25mg735,00€50mg1.071,00€100mg1.549,00€200mg2.097,00€1mL*10mM (DMSO)295,00€TGFβRI-IN-1
CAS:TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Fórmula:C20H14D3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:362.4(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Fórmula:C28H27N3O3Pureza:98%Cor e Forma:SolidPeso molecular:453.53JA310
CAS:JA310 is a highly selective inhibitor of the MST3 kinase, demonstrating significant cellular potency with an EC50 value of 106 nM [1].Fórmula:C17H19N7OCor e Forma:SolidPeso molecular:337.38Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Fórmula:C24H26N6O2Pureza:98.09% - 99.87%Cor e Forma:SolidPeso molecular:430.5Ref: TM-T9641
1mg42,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€1mL*10mM (DMSO)93,00€CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Cor e Forma:SolidPeso molecular:457.48Ref: TM-T36196
2mg35,00€5mg57,00€10mg90,00€25mg182,00€50mg274,00€100mg434,00€200mg582,00€1mL*10mM (DMSO)57,00€AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.
Fórmula:C21H18FNO3Pureza:98%Cor e Forma:SolidPeso molecular:351.37TEAD-IN-2
CAS:TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.Fórmula:C16H18BrF3N2OCor e Forma:SolidPeso molecular:391.23XL413 xHCl
CAS:BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215
Fórmula:C14H12ClN3O2·xHClPureza:99.37% - 99.67%Cor e Forma:SolidPeso molecular:326.18MSC-4106
CAS:MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.
Fórmula:C18H12F3N3O2Pureza:99.89%Cor e Forma:SoildPeso molecular:359.3GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Fórmula:C20H15N3O4SPureza:97.33%Cor e Forma:SolidPeso molecular:393.42LEQ506
CAS:LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Fórmula:C25H32N6OPureza:99.76%Cor e Forma:SolidPeso molecular:432.56Ref: TM-T11838
1mg64,00€5mg145,00€10mg210,00€25mg338,00€50mg455,00€100mg610,00€200mg823,00€1mL*10mM (DMSO)160,00€IHMT-MST1-58
CAS:IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.
Fórmula:C21H22N6O3SPureza:98.31% - 99.92%Cor e Forma:SolidPeso molecular:438.5CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma
Fórmula:C17H13N3O3SPureza:99.6%Cor e Forma:SolidPeso molecular:339.37GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Fórmula:C18H15N5Pureza:99.85% - 99.86%Cor e Forma:SolidPeso molecular:301.35Ref: TM-T78578
1mg106,00€5mg243,00€10mg437,00€25mg934,00€50mg1.283,00€100mg1.730,00€200mg2.337,00€1mL*10mM (DMSO)251,00€LM-41
CAS:LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Fórmula:C19H14FNO2Pureza:99.73%Cor e Forma:SolidPeso molecular:307.32JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Fórmula:C22H23FN4O3SPureza:98.4%Cor e Forma:SolidPeso molecular:442.51TT-10
CAS:TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.
Fórmula:C11H10FN3OS2Pureza:99.29%Cor e Forma:SolidPeso molecular:283.35FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Cor e Forma:SolidPeso molecular:360.43Ref: TM-T24076
1mg42,00€5mg64,00€10mg99,00€25mg188,00€50mg328,00€100mg528,00€500mg1.130,00€1mL*10mM (DMSO)62,00€ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Fórmula:C18H14N4OSPureza:98.92%Cor e Forma:SolidPeso molecular:334.39GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Fórmula:C14H14N4O3SPureza:99.08%Cor e Forma:SolidPeso molecular:318.35BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.
Fórmula:C21H13BrN2O3Pureza:99.93%Cor e Forma:SolidPeso molecular:421.24SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.
Fórmula:C14H14ClFN2O2Pureza:99.94%Cor e Forma:SolidPeso molecular:296.72ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases
Fórmula:C24H28N4O5Pureza:98%Cor e Forma:SolidPeso molecular:452.5YAP-TEAD-IN-2
CAS:YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Fórmula:C25H24ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:470.92SWTX-143
CAS:SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFórmula:C19H18F3N3OPureza:98%Cor e Forma:SolidPeso molecular:361.36Myristoyl tetrapeptide-12
CAS:Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Fórmula:C32H63N7O5Pureza:98%Cor e Forma:SolidPeso molecular:625.89BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Fórmula:C20H23N3OPureza:99.89%Cor e Forma:SolidPeso molecular:321.42ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95TGFβ-IN-5
CAS:TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Fórmula:C20H16N4Pureza:99.29% - 99.62%Cor e Forma:SolidPeso molecular:312.37TP0427736
CAS:TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Fórmula:C14H10N4S2Pureza:97.26%Cor e Forma:SolidPeso molecular:298.39ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Fórmula:C15H15ClN2O4Pureza:99.97%Cor e Forma:SolidPeso molecular:322.74Ref: TM-T35544
1mg95,00€5mg227,00€10mg359,00€25mg630,00€50mg882,00€100mg1.188,00€200mg1.596,00€500mg2.357,00€1mL*10mM (DMSO)251,00€Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,
Fórmula:C28H26N2O12P2Pureza:98.48%Cor e Forma:SolidPeso molecular:644.463,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Fórmula:C17H14O4Pureza:98%Cor e Forma:SolidPeso molecular:282.29DT-6
CAS:DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing
Fórmula:C89H130N20O29S2Pureza:98%Cor e Forma:SolidPeso molecular:2008.23TM2 TEAD inhibitor
CAS:TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4Fórmula:C26H33N3O3Pureza:99.91%Cor e Forma:SolidPeso molecular:435.57GNE-7883
CAS:GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Fórmula:C28H29FN6O2Pureza:97.61%Cor e Forma:SolidPeso molecular:500.57Ref: TM-T78558
1mg116,00€5mg283,00€10mg455,00€25mg747,00€50mg1.026,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)310,00€ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFórmula:C20H18FN3OPureza:>99.99%Cor e Forma:SolidPeso molecular:335.37MYF-03-176
CAS:MYF-03-176 is an orally active TEAD1/3/4 inhibitor with IC₅₀ values of 47/32/71 nM. inhibits TEAD transcriptional activity and cancer cell growth, antitumour.Fórmula:C19H18F4N4O2Cor e Forma:SolidPeso molecular:410.37PMMB-187
CAS:PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Fórmula:C27H23BrN2O6S2Cor e Forma:SolidPeso molecular:615.52TEAD-IN-20
CAS:TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.Fórmula:C20H19F3N4O3Cor e Forma:SolidPeso molecular:420.39M3686
CAS:M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Fórmula:C21H18F3N5O2Cor e Forma:SolidPeso molecular:429.395(+)-ITD-1
CAS:(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).Fórmula:C27H29NO3Cor e Forma:SolidPeso molecular:415.52CDD-1431
CAS:CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.Fórmula:C33H38N8O5SCor e Forma:SolidPeso molecular:658.77YAP/TAZ inhibitor-3
CAS:YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.Fórmula:C21H18F3NO3Pureza:99.63%Cor e Forma:SolidPeso molecular:389.37Ref: TM-T87651
1mg90,00€5mg215,00€10mg344,00€25mg695,00€50mg1.108,00€100mg1.791,00€200mg2.412,00€1mL*10mM (DMSO)236,00€Kartogenin sodium
CAS:Kartogenin (KGN) sodium acts as an inducer of chondrogenic tissue formation (EC 50: 100 nM). It promotes chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. Additionally, Kartogenin sodium aids tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. It is extensively utilized in cell-free therapies for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. The compound is also vital for cartilage repair, coordinating limb development, and osteoarthritis (OA) research [1] [2] [3] [4].Fórmula:C20H14NNaO3Cor e Forma:SolidPeso molecular:339.32TEAD-IN-10
CAS:TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].Fórmula:C15H14F3NOCor e Forma:SolidPeso molecular:281.27(Rac)-SAG
CAS:(Rac)-SAG, an isoform of SAG, is a potent Smoothened (Smo) receptor agonist (EC₅₀ = 3 nM; Kd = 59 nM) that activates the Hedgehog signaling pathway and counteracts Cyclopamine's inhibition of Smo [1] [2] [3].Fórmula:C28H28ClN3OSCor e Forma:SolidPeso molecular:490.06TGFβ1-IN-1
CAS:TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.Fórmula:C22H24N2O3Pureza:99.89% - 99.89%Cor e Forma:SolidPeso molecular:364.438Ref: TM-T61389
1mg50,00€5mg105,00€10mg170,00€25mg340,00€50mg557,00€100mg893,00€200mg1.198,00€1mL*10mM (DMSO)117,00€Carboxylesterase-IN-3
CAS:Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.
Fórmula:C11H6Cl2N4OSPureza:97.49% - 98.47%Cor e Forma:SolidPeso molecular:313.16
