Gama-secretase
Os inibidores da gama-secretase são compostos que têm como alvo o complexo enzimático gama-secretase, que está envolvido na clivagem da proteína precursora do amiloide (APP) para produzir peptídeos beta-amiloides. Esses peptídeos podem se agregar para formar placas amiloides, uma característica da doença de Alzheimer. Ao inibir a gama-secretase, esses compostos visam reduzir a produção de beta-amiloide e sua acumulação no cérebro, sendo, portanto, um foco importante na pesquisa sobre a doença de Alzheimer. Na CymitQuimica, oferecemos inibidores da gama-secretase para apoiar sua pesquisa em biologia amiloide, terapia do Alzheimer e doenças neurodegenerativas.
Foram encontrados 63 produtos de "Gama-secretase"
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CB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Fórmula:C15H18N2OPureza:99.44%Cor e Forma:SolidPeso molecular:242.32Brontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Pureza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:143.93 kDaDemcizumab
CAS:Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.34 kDaRovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.02 kDaNavicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Cor e Forma:LiquidRovalpituzumab MMAE
Rovalpituzumab-MMAE (Anti-DLL3 Reference Antibody), produced in CHO cells, consists of a huIgG1 heavy chain and a hukappa light chain. The molecular weight of this antibody is predicted to be 145.02 kDa.Cor e Forma:LiquidPeso molecular:145 kDaSAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Fórmula:C96H163N36F3O25SCor e Forma:SolidPeso molecular:2310.6Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Fórmula:C62H97N15O22S3Cor e Forma:SolidPeso molecular:1500.72PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Fórmula:C20H19ClF3NO3SCor e Forma:SolidPeso molecular:445.88SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Fórmula:C27H28FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:505.54PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Fórmula:C20H18ClFN2O3SCor e Forma:SolidPeso molecular:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Fórmula:C94H162N36O23SPureza:98%Cor e Forma:SolidPeso molecular:2196.58γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Fórmula:C25H23F3N4O2Cor e Forma:SolidPeso molecular:468.48CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Fórmula:C17H19N3O2SPureza:99%Cor e Forma:SolidPeso molecular:329.42FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFórmula:C22H22ClN5O2Cor e Forma:SolidPeso molecular:423.9RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFórmula:C17H14FN3O2Pureza:99.79%Cor e Forma:SoildPeso molecular:311.31Ref: TM-T35566
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg215,00€50mg371,00€100mg537,00€Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Fórmula:C64H98N15F3O25S3Pureza:98%Cor e Forma:SolidPeso molecular:1614.81BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Fórmula:C26H26F6N4O3Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:556.55β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Fórmula:C24H40O2Pureza:98.91% - 99.89%Cor e Forma:SoildPeso molecular:360.57Jagged-1 (188-204)
CAS:Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin.Fórmula:C93H127N25O26S3Pureza:98%Cor e Forma:SolidPeso molecular:2107.4Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Fórmula:C23H25N5O4SPureza:98.14%Cor e Forma:SolidPeso molecular:467.54Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Pureza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:146.22 kDaγ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Fórmula:C24H23FN4OSPureza:98%Cor e Forma:SolidPeso molecular:434.53JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Fórmula:C23H24N2O3Pureza:99.61%Cor e Forma:SolidPeso molecular:376.45Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Fórmula:C95H128F3N25O28S3Pureza:99.48%Cor e Forma:SolidPeso molecular:2221.37IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Fórmula:C15H15NO5S2Pureza:97.96% - 98.38%Cor e Forma:SolidPeso molecular:353.41FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Fórmula:C25H30N2O5Pureza:99.81% - ≥98%Cor e Forma:SolidPeso molecular:438.52Ref: TM-T3075
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg94,00€25mg168,00€50mg295,00€100mg513,00€500mg1.125,00€γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Fórmula:C24H25ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:453MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Fórmula:C21H21ClF2NaO4SCor e Forma:SolidPeso molecular:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Fórmula:C23H27N3O4Pureza:97.07%Cor e Forma:SolidPeso molecular:409.48Ref: TM-T9015
1mg35,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg112,00€25mg197,00€50mg290,00€100mg420,00€200mg590,00€RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Fórmula:C25H28F3N7Pureza:99.50%Cor e Forma:SolidPeso molecular:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Fórmula:C20H14D3FO2SCor e Forma:SolidPeso molecular:343.43Tarextumab
CAS:Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.Pureza:95%Cor e Forma:LiquidPeso molecular:~150 kDaDilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Pureza:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:199.37 kDatCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Fórmula:C24H44O2Pureza:98%Cor e Forma:SolidPeso molecular:364.61LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Fórmula:C26H23F2N3O4Pureza:98%Cor e Forma:SolidPeso molecular:479.48ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Fórmula:C19H20BrClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Fórmula:C22H29N5O8Pureza:98.80%Cor e Forma:SolidPeso molecular:491.49Ref: TM-T12770
1mg152,00€5mg364,00€1mL*10mM (DMSO)394,00€10mg565,00€25mg1.044,00€50mg1.773,00€100mg2.602,00€ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Fórmula:C19H20BrClN2O3SPureza:99.69%Cor e Forma:SolidPeso molecular:471.8Ref: TM-T11178L
1mg154,00€5mg370,00€1mL*10mM (DMSO)424,00€10mg583,00€25mg858,00€50mg1.170,00€100mg1.575,00€Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Fórmula:C24H24N4O2Cor e Forma:SolidPeso molecular:400.47BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Fórmula:C23H23FN6OCor e Forma:SolidPeso molecular:418.47JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Cor e Forma:SolidPeso molecular:364.44Aβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Fórmula:C29H26N4O2Pureza:98%Cor e Forma:SolidPeso molecular:462.54Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Fórmula:C24H26N6O2Pureza:98.09% - 99.87%Cor e Forma:SolidPeso molecular:430.5Ref: TM-T9641
1mg42,00€1mL*10mM (DMSO)93,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Fórmula:C25H22F4N6O2Pureza:98%Cor e Forma:SolidPeso molecular:514.47RR-11a
CAS:RR-11a is a synthetic enzyme Legumain inhibitor.
Fórmula:C24H28N6O10Pureza:98%Cor e Forma:SolidPeso molecular:560.51CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFórmula:C17H20ClN3O2SPureza:99.02%Cor e Forma:SolidPeso molecular:365.88γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Fórmula:C23H19FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:402.42γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Fórmula:C24H24N4OSPureza:99.75% - 99.96%Cor e Forma:SolidPeso molecular:416.54γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFórmula:C28H22F2N4O2Cor e Forma:SolidPeso molecular:484.5
