Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Foram encontrados 180 produtos de "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Fórmula:C24H24Cl2N4O4Pureza:99.27% - ≥95%Cor e Forma:SolidPeso molecular:503.38Ref: TM-T3456
1mg50,00€5mg114,00€10mg167,00€25mg294,00€50mg444,00€100mg670,00€500mg1.341,00€1mL*10mM (DMSO)127,00€Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Fórmula:C29H34N6O4S2Pureza:97.67% - 98.44%Cor e Forma:SolidPeso molecular:594.75KHS 101
CAS:KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.
Fórmula:C18H21N5SPureza:99.63%Cor e Forma:SolidPeso molecular:339.46Ferulic acid sodium
CAS:Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.Fórmula:C10H9NaO4Pureza:99.58%Cor e Forma:White Crystalline PowderPeso molecular:216.16R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Fórmula:C18H14ClFN4OPureza:98.422%Cor e Forma:SolidPeso molecular:356.78Ref: TM-TQ0317
1mg39,00€2mg52,00€5mg84,00€10mg130,00€25mg264,00€50mg423,00€100mg640,00€1mL*10mM (DMSO)93,00€Alofanib
CAS:Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.Fórmula:C19H15N3O6SPureza:99.53% - 99.81%Cor e Forma:SolidPeso molecular:413.4KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Cor e Forma:SolidPeso molecular:332.4Nintedanib esylate
CAS:Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/βFórmula:C31H33N5O4·C2H6O3SPureza:99.43% - 99.98%Cor e Forma:SolidPeso molecular:649.76FIIN-2
CAS:FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.Fórmula:C35H38N8O4Pureza:97.82% - 99.65%Cor e Forma:Crystalline SolidPeso molecular:634.73LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Fórmula:C21H19Cl2N5O2Pureza:97.22% - 99.46%Cor e Forma:SolidPeso molecular:444.31Ref: TM-T2361
1mg47,00€5mg92,00€10mg145,00€25mg281,00€50mg447,00€100mg670,00€200mg888,00€1mL*10mM (DMSO)101,00€Erdafitinib
CAS:Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.Fórmula:C25H30N6O2Pureza:97.00% - 99.36%Cor e Forma:SolidPeso molecular:446.54ASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Fórmula:C18H19F2N5O4Pureza:99.8% - 99.89%Cor e Forma:SolidPeso molecular:407.37AZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Fórmula:C26H33N5O3Pureza:99.37% - 99.88%Cor e Forma:SolidPeso molecular:463.57Ref: TM-T1948
2mg37,00€5mg50,00€10mg59,00€25mg84,00€50mg107,00€100mg147,00€200mg207,00€500mg348,00€1mL*10mM (DMSO)52,00€CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.59%Cor e Forma:SolidPeso molecular:486.31Ref: TM-T2608
5mg71,00€10mg102,00€25mg205,00€50mg334,00€100mg537,00€500mg1.134,00€1mL*10mM (DMSO)A consultarPD173074
CAS:PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.Fórmula:C28H41N7O3Pureza:98.15% - 98.21%Cor e Forma:Yellow SolidPeso molecular:523.67Ref: TM-T2642
5mg40,00€10mg54,00€25mg94,00€50mg133,00€100mg210,00€200mg371,00€500mg620,00€1mL*10mM (DMSO)56,00€SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Cor e Forma:Yellow-Green SolidPeso molecular:296.32PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.92%Cor e Forma:SolidPeso molecular:532.51Ref: TM-T23127
1mg34,00€5mg96,00€10mg141,00€25mg289,00€50mg465,00€100mg662,00€200mg888,00€1mL*10mM (DMSO)118,00€XL 999
CAS:Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）Fórmula:C26H28FN5OPureza:98.24% - 99.55%Cor e Forma:SolidPeso molecular:445.53PD-166866
CAS:PD-166866 is a selective FGFR tyrosine kinase inhibitor.Fórmula:C20H24N6O3Pureza:98.29%Cor e Forma:SolidPeso molecular:396.44BO-264
CAS:BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).Fórmula:C18H19N5O3Pureza:98.03% - 99.81%Cor e Forma:SolidPeso molecular:353.38
