Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Foram encontrados 170 produtos de "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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PD168393
CAS:<p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>Fórmula:C17H13BrN4OPureza:99.13% - 99.83%Cor e Forma:SolidPeso molecular:369.22Lenvatinib mesylate
CAS:<p>Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.</p>Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Cor e Forma:SolidPeso molecular:522.96SSR128129E
CAS:<p>SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.</p>Fórmula:C18H15N2O4·NaPureza:98.79% - ≥95%Cor e Forma:SolidPeso molecular:346.31H3B-6527
CAS:<p>H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.</p>Fórmula:C29H34Cl2N8O4Pureza:97.45%Cor e Forma:SolidPeso molecular:629.54Futibatinib
CAS:<p>Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.</p>Fórmula:C22H22N6O3Pureza:97.66% - 99.44%Cor e Forma:SolidPeso molecular:418.45FGFR2-IN-3
CAS:<p>FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].</p>Fórmula:C28H24FN7O2Pureza:99.63%Cor e Forma:SoildPeso molecular:509.53TG 100801
CAS:<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Fórmula:C33H30ClN5O3Pureza:99.28% - 99.61%Cor e Forma:SolidPeso molecular:580.08CPL304110
CAS:<p>CPL304110: oral, selective FGFR 1-3 inhibitor; IC50 - FGFR1: 0.75nM, FGFR2: 0.5nM, FGFR3: 3.05nM.</p>Fórmula:C25H30N6O2Cor e Forma:SolidPeso molecular:446.54FGFR3-IN-5
CAS:<p>FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.</p>Fórmula:C24H24FN7O3Cor e Forma:SolidPeso molecular:477.49MAX-40279 hydrochloride
CAS:<p>MAX-40279 HCl: potent FLT3/FGFR inhibitor; potential in AML research.</p>Fórmula:C22H24ClFN6OSCor e Forma:SolidPeso molecular:474.98MAX-40279 hemifumarate
CAS:<p>MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.</p>Fórmula:C48H50F2N12O6S2Cor e Forma:SolidPeso molecular:993.12FGFR4-IN-11
CAS:<p>FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.</p>Fórmula:C29H29N5O5Cor e Forma:SolidPeso molecular:527.57FGFR3-IN-1
CAS:<p>FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).</p>Fórmula:C28H39N9O3SCor e Forma:SolidPeso molecular:581.73SSR128129E free acid
CAS:<p>SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).</p>Fórmula:C18H16N2O4Pureza:98%Cor e Forma:SolidPeso molecular:324.33FGFR4-IN-5
CAS:<p>FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.</p>Fórmula:C23H23Cl2N5O5Cor e Forma:SolidPeso molecular:520.37FIIN-4
CAS:<p>FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.</p>Fórmula:C35H38N8O4Pureza:>99.99%Cor e Forma:SolidPeso molecular:634.73FGFR-IN-9
<p>FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).</p>Fórmula:C25H28N6O3SCor e Forma:SolidPeso molecular:492.59FGFR-IN-3
CAS:<p>FGFR-IN-3: potent, oral FGFR modulator, BBB-penetrating, neuroprotective, potential in neurodegeneration study.</p>Fórmula:C18H27F2N5O2Cor e Forma:SolidPeso molecular:383.44Derazantinib Racemate
CAS:<p>Derazantinib Racemate is an oral ATP competitive kinase inhibitor targeting FGFR1/2/3 (IC50s: 4.5/1.8/4.5 nM).</p>Fórmula:C29H29FN4OPureza:98%Cor e Forma:SolidPeso molecular:468.57SUN13837
CAS:<p>SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.</p>Fórmula:C21H29N5O2Cor e Forma:SolidPeso molecular:383.49
