Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Foram encontrados 180 produtos de "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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JK-P3
CAS:JK-P3: a pyrazole inhibitor of VEGFR-2 (IC50: 7.8 μM), stalls FGFR 1/3 in vitro, halts HUVEC wound healing/tube formation, not cell growth.Fórmula:C18H17N3O3Pureza:99.57%Cor e Forma:SolidPeso molecular:323.35Nintedanib
CAS:Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/Fórmula:C31H33N5O4Pureza:98% - 99.92%Cor e Forma:SolidPeso molecular:539.62Dovitinib
CAS:Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.
Fórmula:C21H21FN6OPureza:99.35% - 99.92%Cor e Forma:SolidPeso molecular:392.43PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Fórmula:C18H18Cl2N6OPureza:97.39%Cor e Forma:SolidPeso molecular:405.28ODM-203
CAS:ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor ImmunityFórmula:C26H21F2N5O2SPureza:99.85%Cor e Forma:SolidPeso molecular:505.54KHS101 hydrochloride
CAS:KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.Fórmula:C18H22ClN5SPureza:99.6%Cor e Forma:SolidPeso molecular:375.92Ref: TM-T5170
2mg34,00€5mg52,00€10mg80,00€25mg147,00€50mg239,00€100mg350,00€200mg497,00€1mL*10mM (DMSO)58,00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Cor e Forma:SolidPeso molecular:375.47DGY-06-116
CAS:DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.Fórmula:C32H33ClN8O2Pureza:97.65%Cor e Forma:SolidPeso molecular:597.11Ref: TM-T22306
2mg39,00€5mg60,00€10mg92,00€25mg173,00€50mg269,00€100mg404,00€200mg570,00€1mL*10mM (DMSO)66,00€Infigratinib
CAS:Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 andFórmula:C26H31Cl2N7O3Pureza:98% - 98.97%Cor e Forma:SolidPeso molecular:560.48Ref: TM-T1975
5mg44,00€10mg57,00€25mg84,00€50mg90,00€100mg144,00€200mg259,00€500mg437,00€1mL*10mM (DMSO)48,00€TG 100801
CAS:TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).Fórmula:C33H30ClN5O3Pureza:99.28% - 99.61%Cor e Forma:SolidPeso molecular:580.08FGFR2-IN-3
CAS:FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].
Fórmula:C28H24FN7O2Pureza:99.63%Cor e Forma:SoildPeso molecular:509.53FGFR-IN-13
CAS:FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].Fórmula:C23H21N5O3Peso molecular:415.44Aminoquinuride
CAS:Surfen, or Aminoquinuride, reduces inflammation but blocks remyelination in MS mouse models and regulates murine T cell activation.Fórmula:C21H20N6OCor e Forma:SolidPeso molecular:372.42FGFR4-IN-5
CAS:FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.Fórmula:C23H23Cl2N5O5Cor e Forma:SolidPeso molecular:520.37MAX-40279
CAS:MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.Fórmula:C22H23FN6OSCor e Forma:SolidPeso molecular:438.52FGFR2-IN-2
CAS:FGFR2-IN-2 is a specific FGFR2 inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used in the study of cancer and cardiovascular disease.Fórmula:C23H22N4OPureza:98.09%Cor e Forma:SolidPeso molecular:370.45FGFR2-IN-1
CAS:FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used to study FGFR2-associated cancers.Fórmula:C22H19N3O2Pureza:98.71%Cor e Forma:SolidPeso molecular:357.41CP-547632 hydrochloride
CAS:CP-547632 hydrochloride: oral VEGFR-2/FGF inhibitor (IC50: 11/9 nM), well-tolerated, antitumor.Fórmula:C20H25BrClF2N5O3SCor e Forma:SolidPeso molecular:568.86MAX-40279 hemiadipate
CAS:MAX-40279 hemiadipate: Potent FLT3/FGFR inhibitor; potential in AML treatment. (Patent WO2021180032A1)Fórmula:C50H56F2N12O6S2Cor e Forma:SolidPeso molecular:1023.19TG 100572
CAS:TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2Fórmula:C26H26ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:475.97
